背景:颅内液腔(IFS),也被称为“轴外空间”,“由浅脑沟组成,西尔维安裂缝,基底水箱,第三脑室,第四脑室,和两个侧脑室.在精神分裂症等疾病中,老年痴呆症,帕金森,尤其是脑积水,观察到IFS扩大。
目的:我们的研究旨在确定精神分裂症患者IFS测量值的平均值,并将其与健康对照进行比较。
方法:这项工作已在188例病例中进行,其中88名精神分裂症患者(56名男性和32名女性)符合根据DSM-5诊断标准的精神分裂症和100名健康对照(50名男性和50名女性)。10个参数已用于评估磁共振成像(MRI)扫描的IFS。
结果:显示统计学差异的参数更有利于精神分裂症患者。除了双额叶指数和埃文指数,大多数参数(双尾指数,第四脑室宽度,第四脑室指数,半球前裂的最大宽度,右额叶蛛网膜下腔的最大宽度,左额叶蛛网膜下腔的最大宽度,右Sylvian裂缝的最大宽度,和左Sylvian裂隙的最大宽度)在受检组和对照组之间获得了统计学上的显着差异。
结论:在精神分裂症中,用一些参数来评估脑萎缩更实用,特别是Sylvian裂隙的宽度和双尾指数。
BACKGROUND: The intracranial fluid spaces (IFS), also known as \"the extra-axial spaces,\" consist of the superficial cerebral sulci, the Sylvian fissures, the basal cisterns, the third ventricle, the fourth ventricle, and the two lateral ventricles. In diseases such as schizophrenia, Alzheimer\'s, Parkinson\'s, and especially hydrocephalus, IFS\' enlargements are observed.
OBJECTIVE: Our study aimed to determine the mean values of IFS measurements in patients with schizophrenia and compare them with healthy controls.
METHODS: This work has been carried out on 188 cases, out of which 88 schizophrenia patients (56 men and 32 women) met the diagnostic criteria according to DSM-5 for schizophrenia and 100 healthy controls (50 men and 50 women). The 10 parameters have been used to evaluate IFS on magnetic resonance imaging (MRI) scans.
RESULTS: The parameters showing statistically significant differences were higher in favor of the individual with schizophrenia. Except for the bifrontal index and Evan\'s index, most parameters (the bicaudate index, the fourth ventricle width, the fourth ventricle index, the maximum width of the anterior interhemispheric fissure, the maximum width of the right frontal subarachnoid space, the maximum width of the left frontal subarachnoid space, the maximum width of the right Sylvian fissure, and the maximum width of the left Sylvian fissure) were obtained statistically highly significant differences between the examined and control groups.
CONCLUSIONS: In schizophrenia, it is more practical to evaluate brain atrophy using some parameters, especially the width of the Sylvian fissure and the bicaudate index.