背景:虎杖。等Zucc。主要分布在山西,甘肃,和中国四川省。在韩国和日本也有发现。其干燥的根和根茎被用作草药,并已用于治疗高血糖症和各种炎症性疾病。
目的:本文旨在提供有关提取和纯化的研究进展的最新综述,结构分析,药理作用,虎杖多糖的潜在应用。此外,讨论了该植物未来可能的研究方向。
方法:本文使用“虎杖多糖(PCP)”和“虎杖”作为关键字,并使用电子数据库收集了有关虎杖的相关数据(Elsevier,PubMed,ACS,CNKI,谷歌学者,百度学者,WebofScience),相关书籍,以及有关中草药的经典文献。
结果:不包括不相关和重复的文档,278份文件最终被包括在内,其中88个是中文的,190个是英文的。CiteSpace软件用于可视化该研究领域的趋势和关键字。得出虎杖多糖的提取方法主要有水提醇沉法,微波辅助提取,超声辅助提取,和微喷射萃取。高效液相色谱法和柱色谱法也常用于PCP的分离和纯化。PCP有抗肿瘤作用,免疫调节,低血糖,和抗氧化作用。本文提供了对PCP的更新和更深入的了解,为进一步优化多糖结构和开发PCP作为临床应用的新型功能材料奠定理论基础。
BACKGROUND: Polygonum cuspidatum Sieb. et Zucc. is mainly distributed in Shanxi, Gansu, and Sichuan province of China. It is also found in Korea and Japan. Its dried roots and rhizomes are used as medicinal herbs and have been used to treat hyperglycemia and various inflammatory disorders.
OBJECTIVE: This paper aims to provide an up-to-date review of the developments in the studies involving the extraction and purification, structure analysis, pharmacological effects, and potential applications of polysaccharides obtained from Polygonum cuspidatum. Additionally, the possible future research directions of this plant are discussed.
METHODS: This article used \"Polygonum cuspidatum polysaccharide (PCP)\" and \"Polygonum cuspidatum\" as the keywords and gathered relevant data on Polygonum cuspidatum using electronic databases (Elsevier, PubMed, ACS, CNKI, Google Scholar, Baidu Scholar, Web of Science), relevant books, and classic literature about Chinese herb.
RESULTS: Excluding irrelevant and repetitive documents, 278 documents were finally included, of which 88 were in Chinese and 190 were in English. The CiteSpace software was used to visualize the trends and keywords in this research field. We concluded that the main extraction methods for Polygonum cuspidatum polysaccharide are water extraction and alcohol precipitation, microwave-assisted extraction, ultrasound-assisted extraction, and microjet extraction. High-performance liquid chromatography and column chromatography are also commonly used in the separation and purification of PCP. PCP has antitumor, immunomodulatory, hypoglycemic, and antioxidant effects. This paper provides an updated and deeper understanding of PCP, serving as a theoretical foundation for the further optimization of polysaccharide structures and the development of PCP as a novel functional material for clinical application.