目的:探讨中国中老年人群睡眠总持续时间变异性与脑卒中的关系。
方法:数据来自2011年、2013年、2015年和2018年中国健康与退休纵向研究(CHARLS)的调查。共有3485人参加,在2015年之前没有发生卒中,并于2018年完成随访,我们纳入研究,分析总睡眠时长变异性与新卒中之间的关系.总睡眠持续时间是通过将自我报告的夜间睡眠持续时间和白天午睡求和来计算的。通过计算前三个波的总睡眠持续时间的标准偏差(SD)来确定变异性。使用二元逻辑回归模型来分析这种关联。
结果:在3485名参与者中,183(5.25%)持续发生中风事件。观察到剂量-反应关系,提示卒中风险增加0.2/单位(小时)总睡眠时长变异性[OR(95%CI):1.20(1.01-1.42)].按性别分组分层后,这种增加的风险仅在男性中显著[OR(95%CI):1.44(1.12-1.83)].
结论:总睡眠时间变异性增加与中老年人卒中风险增加相关,独立于年龄等因素,夜间睡眠持续时间,午睡习惯,居住地区,高血压,糖尿病,血脂异常,BMI,吸烟,饮酒习惯,和婚姻状况。然而,在男性中观察到更显著的相关性。
OBJECTIVE: To investigate the association between total sleep duration variability and stroke in the middle-aged and elderly population in China.
METHODS: Data were collected from the 2011, 2013, 2015, and 2018 surveys of the China Health and Retirement Longitudinal Study (CHARLS). A total of 3485 participants, who had not experienced a stroke until 2015 and completed the follow-up in 2018, were enrolled to analyze the relationship between total sleep duration variability and new stroke. Total sleep duration was calculated by summing self-reported nocturnal sleep duration and daytime napping. The variability was determined by calculating the standard deviation (SD) of total sleep duration across the first three waves. A binary logistic regression model was utilized to analyze this association.
RESULTS: Of the 3485 participants, 183 (5.25%) sustained a stroke event. A dose-response relationship was observed, indicating an increased stroke risk of 0.2 per unit (hours) increase in total sleep duration variability [OR (95% CI): 1.20 (1.01-1.42)]. Upon stratification by sex groups, this increased risk was significant only in men [OR (95% CI): 1.44 (1.12-1.83)].
CONCLUSIONS: Increased total sleep duration variability was associated with an increased risk of stroke in the middle-aged and elderly, independent of factors such as age, nocturnal sleep duration, napping habits, region of residence, hypertension, diabetes mellitus, dyslipidemia, BMI, smoking, drinking habits, and marital status. However, a more notable correlation was observed in males.