Spiritual Therapies

精神疗法
  • 文章类型: Journal Article
    背景:心血管疾病(CVD)显著影响患者的生活,不仅影响他们的身体健康,也影响他们的精神福祉。虽然整体护理承认解决精神需求的重要性,在心血管疾病管理中整合护士主导的精神护理仍未得到充分研究。
    目的:本系统综述旨在评估精神和心理干预在提高CVD患者生活质量和减少焦虑方面的有效性。
    方法:遵循PRISMA指南,我们对多个数据库进行了全面搜索(PubMed,Scopus,EMBASE,CINAHL,科克伦图书馆,SID,马吉兰,和WebofScience)获取2013年至2023年间以英语和波斯语发表的相关文章。使用ROB2和ROBINS-I量表评估纳入的实验和准实验研究中的偏倚风险。
    结果:最初的搜索产生了1416篇文章。在应用纳入和排除标准后,随着定性评估,共选择了15项研究,共1035名参与者进行审查。这些研究探讨了精神干预的影响(例如,健康心脏模型,以情感为导向的方法,通信与更高的权力,接受,和关系改善)对焦虑,压力,预期寿命,抑郁症,血液参数,精神体验,疼痛,和CVD患者的负面情绪。所有经过审查的研究都报告了精神干预的积极成果,证明了它们在减少焦虑方面的有效性,抑郁症,疼痛,压力,和负面情绪,同时也提高了生活质量和预期寿命。
    结论:将精神护理纳入心血管疾病患者的常规护理是改善其整体幸福感的一种有希望的方法。这篇综述强调了精神干预在减少各种负面情绪和提高生活质量方面的有效性。
    背景:PROSPERO(CRD42023448687)。
    BACKGROUND: Cardiovascular disease (CVD) significantly impacts patients\' lives, affecting not only their physical health but also their spiritual well-being. While holistic care acknowledges the importance of addressing spiritual needs, the integration of nurse-led spiritual care within CVD management remains understudied.
    OBJECTIVE: This systematic review aimed to evaluate the effectiveness of spiritual and psychological interventions in enhancing quality of life and reducing anxiety among CVD patients.
    METHODS: Following the PRISMA guidelines, we conducted a comprehensive search across multiple databases (PubMed, Scopus, EMBASE, CINAHL, Cochrane Library, SID, Magiran, and Web of Science) for relevant articles published in English and Persian between 2013 and 2023. The risk of bias in included experimental and quasi-experimental studies was assessed using ROB 2 and ROBINS-I scales.
    RESULTS: The initial search yielded 1416 articles. After applying inclusion and exclusion criteria, along with qualitative evaluation, 15 studies with a total of 1035 participants were selected for review. These studies explored the impact of spiritual interventions (e.g., healthy heart model, emotion-oriented approach, communication with a higher power, acceptance, and relationship improvement) on anxiety, stress, life expectancy, depression, blood parameters, spiritual experiences, pain, and negative emotions in CVD patients. All reviewed studies reported positive outcomes with spiritual interventions, demonstrating their effectiveness in reducing anxiety, depression, pain, stress, and negative emotions, while also improving quality of life and possibly life expectancy.
    CONCLUSIONS: Integrating spiritual care into routine care for CVD patients presents a promising approach to improve their overall well-being. This review highlights the effectiveness of spiritual interventions in reducing various negative emotions and enhancing quality of life.
    BACKGROUND: PROSPERO (CRD42023448687).
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  • 文章类型: Journal Article
    目的:这项荟萃分析旨在确定精神干预如何影响癌症患者的身体,情感,精神成果和生活质量。
    方法:在2012年至2024年5月之间,Cochrane图书馆,Scopus,PubMed,和WebofScience进行了搜索,并考虑了系统评论和荟萃分析清单的首选报告项目。纳入26项随机对照试验,在荟萃分析中合成了16个。使用Cochrane偏倚风险方法学对偏倚风险进行随机研究评估。建议的分级,评估,发展,并采用评估工具进行证据确定性。异质性通过I2和Q统计表示。为效果大小计算了对冲g。Egger和Kendall的Tau被用于发表偏见。
    结果:精神干预对疲劳(Hedges\sg=0.900,p<0.001)和疼痛(Hedges\sg=0.670,p<0.001)产生了有益的影响,但对总体症状负担(Hedges\sg=0.208,p=0.176)没有影响。发现焦虑有显著影响(对冲组g=0.301,p<0.001),凹陷(对冲的g=0.175,p=0.016),和心理困扰(对冲的g=0.178,p=0.024),除了绝望(对冲的g=0.144,p=0.091)。精神干预增强了信仰(对冲的g=0.232,p=0.035),生命的意义(对冲的g=0.259,p=0.002),精神福祉(对冲基金的g=0.268,p<0.001),和生活质量(对冲基金g=245,p<0.001)。主持人分析指出,癌症分期,总持续时间,交付格式,提供者资格,内容,精神干预的概念基础显著影响身体,情感,精神成果和生活质量。
    结论:这项荟萃分析强调了精神干预对患者结局的影响大小不同的益处,以及癌症患者的生活质量,以及如何将这些方法纳入临床实践。
    OBJECTIVE: This meta-analysis aimed to determine how spiritual interventions affect cancer patients\' physical, emotional, and spiritual outcomes and quality of life.
    METHODS: Between 2012 and May 2024, the Cochrane Library, Scopus, PubMed, and Web of Science were searched considering the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Twenty-six randomized controlled trials were included, and 16 were synthesized in the meta-analysis. Bias risk was evaluated using the Cochrane risk-of-bias methodology for randomized studies. The Grading of Recommendations, Assessment, Development, and Evaluations tool was employed for evidence certainty. Heterogeneity was expressed through I2 and Q statistics. Hedge\'s g was calculated for effect sizes. Egger\'s and Kendall\'s Tau were used for publication bias.
    RESULTS: Spiritual interventions yielded beneficial effects on fatigue (Hedges\'s g = 0.900, p < 0.001) and pain (Hedges\'s g = 0.670, p < 0.001) but not for overall symptom burden (Hedges\'s g = 0.208, p = 0.176). Significant effects were found for anxiety (Hedges\'s g = 0.301, p < 0.001), depression (Hedges\'s g = 0.175, p = 0.016), and psychological distress (Hedges\'s g = 0.178, p = 0.024), except for hopelessness (Hedges\'s g = 0.144, p = 0.091). Spiritual interventions enhanced faith (Hedges\'s g = 0.232, p = 0.035), the meaning of life (Hedges\'s g = 0.259, p = 0.002), spiritual well-being (Hedges\'s g = 0.268, p < 0.001), and quality of life (Hedges\'s g = 245, p < 0.001). Moderator analysis pointed out that cancer stage, total duration, delivery format, providers\' qualification, content, and conceptual base of spiritual interventions significantly affect physical, emotional, and spiritual outcomes and quality of life.
    CONCLUSIONS: This meta-analysis highlighted the benefits of spiritual interventions with varying effect sizes on patients\' outcomes, as well as quality of life in cancer, and shed on how to incorporate these approaches into clinical practice.
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  • 文章类型: Journal Article
    这项研究的目的是确定在精神中心寻求精神治疗(ST)的主要动机和期望。这是在马托格罗索州的两个精神中心进行的定性研究,巴西。ST被认为是以磁流为主要治疗方法的一组活动。我们观察到,大多数参与者首先寻求卫生专业人员的治疗,在结果不足之后,他们去寻找圣。他们的治疗同时进行,对于参与者来说,它们是相辅相成的。导致参与者进入ST的动机从身体原因到心理健康投诉甚至家庭冲突不等。投资于这种类型的治疗的一种可能性是由于参与者渴望更全面的方法,而不仅仅是解决直接困扰他们的问题。
    The objective of this study is to identify the main motivations and expectations for seeking spiritual treatment (ST) in  spiritist centers. This is a qualitative study developed at two spiritist centers in the state of Mato Grosso, Brazil. ST was considered as the set of activities that use magnetic current as the main treatment method. We observed that most of the participants first sought treatments from health professionals and that, after insufficient results, they went in search of ST. Their treatments take place simultaneously and, for the participants, they complement each other. The motivations that led the participants to ST ranged from physical reasons to mental health complaints and even family conflicts. One possibility for investing in this type of treatment is due to the participants\' desire for a more comprehensive approach, and not as a mere solution to the problem that directly afflicts them.
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  • 文章类型: Journal Article
    这项研究的目的是检查临床医生在第一期精神综合心理治疗(SIP)中使用不同类型的精神干预措施与客户第二次返回的可能性之间的关联。总的来说,来自实践研究网络中33个环境的154名SIPs从业者在会后摘要清单上报告了他们实施不同方法来解决客户的宗教/灵性问题。大约80%或更多的临床医生在第一次会议中实施了至少一次精神干预;平均而言,临床医生在检查表中使用了3.26项干预措施(SD=3.66).发生在1,094个客户中有20%或更多的客户中,最常用的精神干预包括倾听精神问题,讨论同情和希望,肯定客户的神圣价值,并试图相信上帝。总的来说,近五分之一的客户没有回来第二次会议。专注于在双变量分析的第二次会议中与客户参与经验相关的干预措施,对客户问题和解决方案的精神层面的讨论与客户参与SIP的可能性增加了118%;相比之下,对希望的讨论与治疗参与度下降40%有关。总之,调查结果强调了在SIP开始时实施干预措施以照顾客户的灵性和/或宗教信仰的潜在机会和风险。需要进行研究以了解与有效使用精神干预措施和相应培训临床医生的方法相关的因素。(PsycInfo数据库记录(c)2024APA,保留所有权利)。
    The purpose of this study was to examine associations between clinicians\' use of varying types of spiritual interventions in the first session of spiritually integrated psychotherapies (SIPs) and clients\' likelihood of returning for a second session. In total, 154 practitioners of SIPs from 33 settings in a practice-research network reported on their implementation of different methods for addressing clients\' religion/spirituality on an after-session summary checklist. Roughly 80% or more of the clinicians implemented at least one spiritual intervention in the first session; on average, clinicians used 3.26 (SD = 3.66) of the interventions on the checklist. Occurring with 20% or more of the 1,094 clients, the most commonly used spiritual interventions included listening to spiritual issues, discussing compassion and hope, affirming clients\' divine worth and attempts to trust God. In total, nearly one in five clients did not return for a second session. Focusing on interventions that were empirically linked with clients\' engagement in a second session in bivariate analyses, discussion of spiritual dimensions of clients\' problems and solutions was associated with a 118% greater probability that clients engaged in SIPs; in contrast, discussion of hope was linked with a 40% decrease in treatment engagement. In conclusion, findings highlight the potential opportunities and risks for implementing interventions that attend to clients\' spirituality and/or religious faith at the start of SIPs. Research is needed to understand factors associated with the effective use of spiritual interventions and methods of training clinicians accordingly. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
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  • 文章类型: Journal Article
    精神自我护理被定义为一系列以患者为中心或以家庭为中心的精神活动,旨在促进健康和福祉。在癌症等慢性疾病中,护理的责任通常落在病人或他们的家人身上,为了实现这一目标,需要对患者的自我护理实践进行准确评估。这项研究的目的是翻译,文化适应,并检查波斯语版本的精神自我护理实践量表(SSCPS)在癌症患者中的心理测量学。该量表旨在直接对患者进行管理,以评估他们的精神自我护理实践。这项横断面研究是在Afzalipoor医院的肿瘤病房进行的,JavadAl-Aemeh诊所,和附属于克尔曼医学科学大学的内科医生诊所,伊朗东南部。这项研究包括面部效度的定性和定量评估,内容有效性,项目分析,探索性和验证性因子分析(结构效度),和可靠性。数据收集发生在2023年3月20日至2023年12月30日之间。量表的内容效度指数计算为0.948,大多数项目的修订注释大多较小。项目内容有效性指数范围从0.7到1。探索性因子分析揭示了一个包含23个项目的五因素解决方案,解释总方差的61.251%。确定的因素被标记为“个人和人际精神实践”,\'\'塑造和加强关系实践,\'\'宗教习俗,\'\'身体的精神实践,\'和\'重塑关系实践。大多数验证性因子分析指标均令人满意(χ2/df=1.665,CFI=0.934,FI=0.935,RMSEA=0.058)。总量表的Cronbach'sα系数为0.89,而分量表的范围为0.596至0.882。波斯语版本的SSCPS包含23个项目,证明了评估伊朗癌症患者精神实践表现的可靠性和有效性。与原始版本相比,波斯语改编的SSCPS简明扼要,使其成为未来伊朗癌症患者精神自我护理研究和实践的合适工具。
    Spiritual self-care is defined as a set of patient-centered or family-centered spiritual activities aimed at promoting health and well-being. In chronic diseases such as cancer, the responsibility for care typically falls on the patient or their family, necessitating an accurate assessment of the patient\'s self-care practices to achieve this goal. The objective of this study was to translate, culturally adapt, and examine the psychometrics of the Persian version of the spiritual self-care practice scale (SSCPS) in cancer patients. This scale is designed to be administered directly to patients to assess their spiritual self-care practices. This cross-sectional study was conducted at the oncology ward in Afzalipoor Hospital, Javad Al-Aemeh Clinic, and Physicians Clinics affiliated with Kerman University of Medical Sciences in Kerman, southeast Iran. The study included qualitative and quantitative assessments of face validity, content validity, item analysis, exploratory and confirmatory factor analysis (construct validity), and reliability. Data collection took place between March 20, 2023, and December 30, 2023. The scale\'s content validity index was calculated to be 0.948, with mostly minor revision comments for most items. The item-content validity indices ranged from 0.7 to 1. Exploratory factor analysis revealed a five-factor solution with 23 items, explaining 61.251% of the total variance. The identified factors were labeled as \'personal and interpersonal spiritual practices,\' \'shaping and strengthening relationship practices,\' \'religious practices,\' \'physical spiritual practices,\' and \'reshaping relationship practices.\' Most of the confirmatory factor analysis indices were satisfactory (χ2/df = 1.665, CFI = 0.934, IFI = 0.935, RMSEA = 0.058). The Cronbach\'s α coefficient for the total scale was 0.89, while it ranged from 0.596 to 0.882 for the subscales. The Persian version of SSCPS with 23 items demonstrates reliability and effectiveness in assessing the spiritual practice performance of Iranian cancer patients. Compared to the original version, the Persian adaptation of SSCPS is concise, making it a suitable instrument for future research and practice on spiritual self-care among Iranian cancer patients.
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  • 文章类型: Letter
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  • 文章类型: Journal Article
    对许多人来说,世界卫生组织(WHO)对健康的定义并不反映他们自己对健康的理解,因为它缺乏精神健康等方面。针对这些担忧,世卫组织在2023年呼吁建立一个整合身体的健康愿景,心理,心理,情感,精神,和社会福祉。迄今为止,医生通常不愿意考虑精神方面,因为缺乏关于关系强度的统计证据。关于这一课题的研讨正在涌现。最近在津巴布韦800名感染艾滋病毒的年轻人中进行的一项研究表明,研究参与者是如何进行三个平行导航的,有时与卫生系统相矛盾(宗教,传统,医疗)。冲突的方法导致了多方面的困境(=精神斗争),这与较差的身心健康显着相关。这说明需要在研究中纳入精神方面的健康和福祉,以及医疗保健领域所有利益相关者之间加强合作。
    For many, the World Health Organization\'s (WHO) definition of health does not reflect their own understanding of health, because it lacks aspects such as spiritual wellbeing. Responding to these concerns, the WHO called in 2023 for a vision of health that integrates physical, mental, psychological, emotional, spiritual, and social wellbeing. To date, medical practitioners are often reluctant to consider spiritual aspects, because of a perceived lack of statistical evidence about the strength of relations. Research on this topic is emerging. A recent study among 800 young people living with HIV in Zimbabwe showed how study participants navigated three parallel, at times contradicting health systems (religious, traditional, medical). Conflicting approaches led to multifaceted dilemmas (= spiritual struggles), which were significantly related to poorer mental and physical health. This illustrates the need for inclusion of spiritual aspects for health and wellbeing in research, and of increased collaboration between all stakeholders in healthcare.
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  • 文章类型: Journal Article
    背景:“完全疼痛”的概念在姑息治疗中起着重要作用;这意味着疼痛不仅仅是在身体层面上经历的,而且在心理上,社会和精神层面。了解灵性需要什么,然而,对医疗保健专业人员来说是一个挑战,筛查患者的精神需求也是如此。
    目的:这是一部小说,以研讨会的形式向医学本科生教授精神关怀的跨专业方法。这项研究的目的是评估使用这种格式是否可以实现临床背景下有关精神护理的知识增加。
    方法:在我们大学姑息治疗课程的强制性研讨会中,医生和医院牧师都从不同的角度(躯体领域-精神领域)教授症状控制策略。为了评估精神领域教授的内容,我们进行了由两部分组成的问卷:利用比较自我评估(CSA)增益的具体结果评价和利用李克特量表对研讨会的整体认知.
    结果:总计,52名学生参加。关于具体的结果评估,在确定总疼痛的能力(84.8%)和实现其在临床环境中的相关性(77.4%)方面获得了最大的增益.最低的,但是在识别可能从精神咨询中受益的患者的能力方面仍然取得了相当大的改善(60.9%)。如置信区间所证实的,学习益处都是显著的。总的来说,学生们对研讨会的结构感到满意。内容清晰且可理解地交付,在李克特量表上达到4.3的平均得分(4=同意)。该内容被认为与后来的医学工作总体相关(平均4.3)。大多数学生不会选择仅围绕精神关怀的研讨会(平均2.6)。
    结论:我们得出的结论是,在现有的医学课程中采用跨专业的方法来实施精神护理教育,例如姑息药物,在医学生中具有可行性和良好的认知。学生不希望研讨会,只围绕精神护理,但更喜欢与临床实践和策略紧密联系。
    BACKGROUND: The concept of \"total pain\" plays an important role in palliative care; it means that pain is not solely experienced on a physical level, but also within a psychological, social and spiritual dimension. Understanding what spirituality entails, however, is a challenge for health care professionals, as is screening for the spiritual needs of patients.
    OBJECTIVE: This is a novel, interprofessional approach in teaching undergraduate medical students about spiritual care in the format of a seminar. The aim of this study is to assess if an increase in knowledge about spiritual care in the clinical context is achievable with this format.
    METHODS: In a mandatory seminar within the palliative care curriculum at our university, both a physician and a hospital chaplain teach strategies in symptom control from different perspectives (somatic domain - spiritual domain). For evaluation purposes of the content taught on the spiritual domain, we conducted a questionnaire consisting of two parts: specific outcome evaluation making use of the comparative self-assessment (CSA) gain and overall perception of the seminar using Likert scale.
    RESULTS: In total, 52 students participated. Regarding specific outcome evaluation, the greatest gain was achieved in the ability to define total pain (84.8%) and in realizing its relevance in clinical settings (77.4%). The lowest, but still fairly high improvement was achieved in the ability to identify patients who might benefit from spiritual counselling (60.9%). The learning benefits were all significant as confirmed by confidence intervals. Overall, students were satisfied with the structure of the seminar. The content was delivered clearly and comprehensibly reaching a mean score of 4.3 on Likert scale (4 = agree). The content was perceived as overall relevant to the later work in medicine (mean 4.3). Most students do not opt for a seminar solely revolving around spiritual care (mean 2.6).
    CONCLUSIONS: We conclude that implementing spiritual care education following an interprofessional approach into existing medical curricula, e.g. palliative medicine, is feasible and well perceived among medical students. Students do not wish for a seminar which solely revolves around spiritual care but prefer a close link to clinical practice and strategies.
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  • 文章类型: Journal Article
    背景:了解灵性和精神护理是护理中整体护理的前提。灵性是人类生存的重要维度,在促进健康中起着至关重要的作用。这项研究的目的是评估护士对精神和精神护理的态度水平。
    方法:对208名护士进行了横断面分析研究设计,以评估Bharatpur医院护士对精神和精神关怀的态度。经过预先测试的半结构化,我们使用自编问卷收集受访者的数据.使用了乐器灵性和精神关怀等级量表。对收集的数据进行编码并输入到MicrosoftOfficeExcel中,并使用SPSS版本22进行分析。
    结果:这项研究的发现表明,在208名受访者中,大多数(74.0%)的受访者年龄在20~29岁,平均值和SD为28.2±5.510.其中,125(60.1%)受访者的态度得分中等,为32-62,83(39.9%)的态度得分较高,为63-92,而0.5%的受访者对灵性和精神关怀的态度得分较低(0-31)。态度水平与社会人口统计学变量之间没有统计学上的显着关系。
    结论:得出的结论是,大多数受访者的态度处于中等水平。需要重点关注在职教育和护士提供精神护理的意识。
    BACKGROUND: Understanding spirituality and spiritual care is a prerequisite for holistic care in nursing. Spirituality is an important dimension of human existence with a crucial role in health promotion. The objective of this study was to assess the level of attitude towards spirituality and spiritual care among nurses.
    METHODS: A cross-sectional analytical study design was used among 208 nurses to assess attitude toward spirituality and spiritual care among nurses of Bharatpur Hospital. A pretested semi-structured, self-administered questionnaire was used to collect data from the respondents. The instrument spirituality and spiritual care rating scales were used. Collected data were coded and entered in Microsoft office excel and SPSS version 22 was used for analysis.
    RESULTS: The finding of the study revealed that, out of 208 respondents, the majority (74.0%) of respondents were of age 20-29 years with a mean and SD of 28.2±5.510. Among all, 125(60.1%) respondents had a moderate attitude score of 32-62, 83(39.9%) had a high level of attitude score of 63-92, whereas 0.5% had a low level of attitude towards spirituality and spiritual care score (0-31).There is no statistically significant relationship between the level of attitude and socio-demographic variables.
    CONCLUSIONS: It is concluded that most of the respondents had a moderate level of attitude. In-service education and awareness on providing spiritual care among nurses needs to be focused.
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  • 文章类型: Systematic Review
    背景:尽管精神干预在儿童癌症患者(CCPs)的护理中至关重要,其有效性尚未得到系统评估。
    目的:为了确定现有的精神干预措施对心理,精神的结果,和CCPs的生活质量(QoL)。
    方法:我们检索了8个数据库,以确定相关的随机对照试验和准实验研究。在随机试验中使用Cochrane偏倚风险工具评估偏倚风险。结果要么在系统叙事综合中进行综合,要么使用随机效应模型进行荟萃分析,在适当的地方。使用标准化平均差(SMD)和95%置信区间(CI)估计合并治疗效果。
    结果:纳入了12项576个CCP的研究。8项研究显示有较高的偏倚风险。现有精神干预对QoL的总体影响(Z=1.05,SMD=0.64,95%CI=-0.15至1.83,p=0.29),焦虑(Z=1.11,SMD=-0.83,95%CI=-2.30至0.64,p=0.28)和抑郁症状(Z=1.06,SMD=-0.49,95%CI=-1.40至0.42,p=0.12)无统计学意义。无显著性发现可归因于纳入研究的高度异质性(QoL:I2=85%;焦虑:I2=90%;抑郁症状:I2=58%)。
    结论:支持现有精神干预对CCP的心理和精神结果以及QoL的积极影响的证据不足。未来的研究应采用更严格的设计和统一的结果措施,以减少偏见和异质性的风险,分别。
    BACKGROUND: Although spiritual intervention is crucial in the care of childhood cancer patients (CCPs), its effectiveness has not yet been systematically evaluated.
    OBJECTIVE: To determine the effectiveness of existing spiritual interventions on psychological, spiritual outcomes, and quality of life (QoL) in CCPs.
    METHODS: We searched eight databases to identify relevant randomized controlled trials and quasi-experimental studies. Risk of bias was assessed using the Cochrane risk-of-bias tool for randomized trials. Results were either synthesized in a systematic narrative synthesis or a meta-analysis using a random effects model, where appropriate. The pooled treatment effect was estimated using the standardized mean difference (SMD) and 95% confidence interval (CI).
    RESULTS: Twelve studies with 576 CCPs were included. Eight studies showed a high risk of bias. The overall effect of existing spiritual interventions on QoL (Z = 1.05, SMD = 0.64, 95%CI = -0.15 to 1.83, P = 0.29), anxiety (Z = 1.11, SMD = -0.83, 95%CI = -2.30 to 0.64, P = 0.28) and depressive symptoms (Z = 1.06, SMD = -0.49, 95%CI = -1.40 to 0.42, P = 0.12) were statistically nonsignificant. The nonsignificant findings could be attributed to the high heterogeneity among the included studies (QoL: I2 = 85%; anxiety: I2 = 90%; depressive symptoms: I2 = 58%).
    CONCLUSIONS: Evidence to support the positive effects of existing spiritual interventions on psychological and spiritual outcomes and QoL in CCPs is insufficient. Future studies should adopt a more rigorous design and unify the outcome measures to reduce the risk of bias and heterogeneity, respectively.
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