背景:先前已提出血液粘弹性的变化是COVID-19和一些突发性耳聋(SD)病例的严重并发症的病因。这是试图验证因SARS-Cov-2感染而入院的患者中的SD病例是否相关。
方法:对COVID-19患者进行前瞻性随访,以高剪切速率(300s-1)监测他们的血液粘度(BV),并定期询问他们最终的听力损失。该测量扩展到2019年和2020年无感染的SD病例和健康正常听力受试者的对照组。
结果:正常范围为4,16±0,62cps。从2月24日开始评估了330例COVID-19病例,2020年3月24日,2021年,其中85人在ICU就诊。在回忆和听力测量音调阈值尽快发展后,检测到9个SD,都属于ICU组。病区组平均BV为4,38±0,43cps,在没有SD的ICU患者中,4,53±0,39cps,在SD的情况下,为4,85±0,52cps,具有统计学上的显著差异。在入院的第6天和第10天之间检测到SD病例中最高的BV升高。2019年,四例向SD咨询,另外两人在2020年没有诊断出COVID-19,BV值正常。
结论:在SARS-Cov-2感染期间,患者可能表现出高BV和SS,尽管住院患者对照组和更大的样本量是必要的,以确认高粘血症的易感性。如果考虑到可能的外观,听力损伤的发生率是相当大的,在COVID-19危重患者的限制范围内。
BACKGROUND: Changes in blood viscoelastic properties have been proposed previosuly as etiopathogenesis for severe complications in COVID-19 and some cases of Sudden Deafness (SD). This is an attempt to verify if SD cases in patients admitted for SARS-Cov-2 infection can be correlated.
METHODS: A prospective follow-up was carried out with COVID-19 patients, monitoring their blood viscosity (BV) at high shear rate (300 s-1) and inquiring them periodically for eventual hearing loss. This measurement was extended to cases bearing of SD in 2019 and 2020 without infection and a control group of healthy normoacoustic subjects.
RESULTS: The normality range was 4,16 ± 0,62 cps. 330 cases admitted for COVID-19 were evaluated from February 24th, 2020 to March 24th, 2021, 85 of them attended in ICU. After anamnesis and Audiometric Tone Thresholds developed as soon as possible, 9 SD were detected, all belonging to ICU group. The mean BV was 4,38 ± 0,43 cps in the ward group, 4,53 ± 0,39 cps in the ICU patients without SD, and 4,85 ± 0,52 cps in the cases with SD, with statistically significant differences. Highest BV elevations in the SD cases were detected between days 6 and 10 of hospital admission. In 2019 four cases consulted with SD, and another two did it in 2020 without a diagnosis of COVID-19, with normal BV values.
CONCLUSIONS: During SARS-Cov-2 infection, patients may show high BV and SS, although an inpatients control group and a larger sample volume are necessary to confirm the predisposition to hyperviscosity. The incidence of hearing damage is considerable if its possible appearance is taken into account, within the limitations of critical patients with COVID-19.