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  • 文章类型: Journal Article
    背景:先前已提出血液粘弹性的变化是COVID-19和一些突发性耳聋(SD)病例的严重并发症的病因。这是试图验证因SARS-Cov-2感染而入院的患者中的SD病例是否相关。
    方法:对COVID-19患者进行前瞻性随访,以高剪切速率(300s-1)监测他们的血液粘度(BV),并定期询问他们最终的听力损失。该测量扩展到2019年和2020年无感染的SD病例和健康正常听力受试者的对照组。
    结果:正常范围为4,16±0,62cps。从2月24日开始评估了330例COVID-19病例,2020年3月24日,2021年,其中85人在ICU就诊。在回忆和听力测量音调阈值尽快发展后,检测到9个SD,都属于ICU组。病区组平均BV为4,38±0,43cps,在没有SD的ICU患者中,4,53±0,39cps,在SD的情况下,为4,85±0,52cps,具有统计学上的显著差异。在入院的第6天和第10天之间检测到SD病例中最高的BV升高。2019年,四例向SD咨询,另外两人在2020年没有诊断出COVID-19,BV值正常。
    结论:在SARS-Cov-2感染期间,患者可能表现出高BV和SS,尽管住院患者对照组和更大的样本量是必要的,以确认高粘血症的易感性。如果考虑到可能的外观,听力损伤的发生率是相当大的,在COVID-19危重患者的限制范围内。
    BACKGROUND: Changes in blood viscoelastic properties have been proposed previosuly as etiopathogenesis for severe complications in COVID-19 and some cases of Sudden Deafness (SD). This is an attempt to verify if SD cases in patients admitted for SARS-Cov-2 infection can be correlated.
    METHODS: A prospective follow-up was carried out with COVID-19 patients, monitoring their blood viscosity (BV) at high shear rate (300 s-1) and inquiring them periodically for eventual hearing loss. This measurement was extended to cases bearing of SD in 2019 and 2020 without infection and a control group of healthy normoacoustic subjects.
    RESULTS: The normality range was 4,16 ± 0,62 cps. 330 cases admitted for COVID-19 were evaluated from February 24th, 2020 to March 24th, 2021, 85 of them attended in ICU. After anamnesis and Audiometric Tone Thresholds developed as soon as possible, 9 SD were detected, all belonging to ICU group. The mean BV was 4,38 ± 0,43 cps in the ward group, 4,53 ± 0,39 cps in the ICU patients without SD, and 4,85 ± 0,52 cps in the cases with SD, with statistically significant differences. Highest BV elevations in the SD cases were detected between days 6 and 10 of hospital admission. In 2019 four cases consulted with SD, and another two did it in 2020 without a diagnosis of COVID-19, with normal BV values.
    CONCLUSIONS: During SARS-Cov-2 infection, patients may show high BV and SS, although an inpatients control group and a larger sample volume are necessary to confirm the predisposition to hyperviscosity. The incidence of hearing damage is considerable if its possible appearance is taken into account, within the limitations of critical patients with COVID-19.
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  • 文章类型: Journal Article
    BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSHL) is defined as an abrupt hearing loss of at least 30dB of unknown cause. The hearing response obtained after intratympanic steroid injection as a salvage treatment after a prior failure of initial systemic steroid treatment was analysed.
    METHODS: An observational study was performed on 125 cases of ISSHL who were diagnosed from 2006 to 2014. Sixteen achieved complete recovery after one week according to Siegel\'s criteria. The remaining 109 cases were analysed in two groups: one that received intratympanic corticosteroid salvage therapy (treatment group) and one that did not (control group). The recovery was analysed after 6 months and 2 years of follow-up.
    RESULTS: The difference between each group at baseline were not statistically significant. After systemic treatment for 7 days, PTA in the control group was 53.13dB and 66.11dB in the treatment group (P<.01). After 6 months, the mean PTA improvement was 10.84dB in the treatment group, and 1.13dB in the control group, a significant difference (P<.0001). Only 10 cases achieved full hearing recovery after intratympanic corticosteroid salvage therapy, none of the patients did so in the control group.
    CONCLUSIONS: Intratympanic corticosteroid rescue for ISSHL acheived hearing improvement for the cases with failure of initial systemic corticosteroid treatment. However, this treatment did not provide complete hearing recovery according to Siegel\'s criteria in most cases.
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  • 文章类型: Consensus Development Conference
    背景:特发性突发性感觉神经性听力损失(ISSNHL)是一种突然的,无法解释的单方面听力损失。
    目的:更新西班牙关于诊断的共识,ISSNHL的治疗和随访。
    方法:在对1966年至2018年3月的文献进行系统回顾之后,以MESH术语“(急性或突然)听力损失或耳聋”,进行了第三次更新,包括1508篇相关论文。
    结果:关于诊断,11ISSNHL临床怀疑,以下诊断测试是强制性的:耳镜检查,针法,音调测听,言语测听,和鼓室测压,低估导电原因。在建立临床诊断后,在治疗开始之前,应该进行全面分析。然后应该要求MRI,理想情况下在诊断后的前15天进行,以减少特定的原因,并帮助了解每种情况下的病理生理学机制。虽然治疗非常有争议,由于其对ISSNHL后生活质量的影响以及与短期类固醇治疗相关的少数罕见不良反应,这种共识建议所有患者都应该接受类固醇治疗,口服和/或鼓室内,取决于每个病人。如果全身性类固醇失败,鼓室内抢救也建议。随访应在第7天和12个月后进行。
    结论:经协商一致,治疗后的结果应报告为纯音调测听中绝对分贝的恢复和言语测听的改善。
    BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is a sudden, unexplained unilateral hearing loss.
    OBJECTIVE: To update the Spanish Consensus on the diagnosis, treatment and follow-up of ISSNHL.
    METHODS: After a systematic review of the literature from 1966 to March 2018, on MESH terms «(acute or sudden) hearing loss or deafness», a third update was performed, including 1508 relevant papers.
    RESULTS: Regarding diagnosis, 11ISSNHL is clinically suspected, the following diagnostic tests are mandatory: otoscopy, acumetry, tonal audiometry, speech audiometry, and tympanometry, to discount conductive causes. After clinical diagnosis has been established, and before treatment is started, a full analysis should be performed. An MRI should then be requested, ideally performed during the first 15 days after diagnosis, to discount specific causes and to help to understand the physiopathological mechanisms in each case. Although treatment is very controversial, due to its effect on quality of life after ISSNHL and the few rare adverse effects associated with short-term steroid treatment, this consensus recommends that all patients should be treated with steroids, orally and/or intratympanically, depending on each patient. In the event of failure of systemic steroids, intratympanic rescue is also recommended. Follow-up should be at day 7, and after 12 months.
    CONCLUSIONS: By consensus, results after treatment should be reported as absolute decibels recovered in pure tonal audiometry and as improvement in speech audiometry.
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  • 文章类型: Journal Article
    BACKGROUND: The objective of our study was to identify the diagnostic and therapeutic approaches in the different ENT Departments of Spain with respect to sudden deafness. We wanted to establish a basis to help to create a new nation-wide consensus, unifying treatment, diagnostic and follow-up criteria for this disease.
    METHODS: We carried out an anonymous Internet survey, addressing Spanish ENT doctors nation-wide (n=2,029), gathering in 33 questions different aspects about diagnostic criteria, additional tests, treatment procedures and prognostic factors in sudden deafness, according to the different protocols and experience of the participants in the survey.
    RESULTS: A total of 293 Spanish ENT doctors (14%) took part anonymously. In relation to diagnostic criteria, is the most noteworthy was the requisite of a confirmed neurosensorial loss (91.1%) followed by \"initiated in less than three days\" (75%) and 3 consecutive frequencies affected (76.4%). More than half of the participants requested an MRI of the IAC/CPA (68.7%) and 88.2% used gadolinium in this test. The prognostic factor most frequently considered was delay in commencement of treatment onset (84.8%). As far as treatment of primary cases, most of the responders agreed on the use of corticosteroids (99.7%). Oral administration was the most widely used (66%), followed by intravenous (29.6%) and intratympanic (1.4%) administration. Ninety-two percent had not had any major complications with systemic steroids. Intratympanic treatments were used by 70% of responders for rescue in failure.
    CONCLUSIONS: In Spain there is currently a significant disparity of concepts regarding the diagnosis of sudden deafness, and more agreement as to using steroids as their treatment. This highlights the need to implement measures to promote a better approach, which would be homogeneous and consensual, to this condition.
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