众所周知,高血压可能导致心力衰竭(HF)的发展。然而,对可能导致遗传性心肌病(HCM)发作的低血压的发展知之甚少,从而促进心力衰竭和早逝。这项研究的目的是验证在HCM的不同阶段是否发生血压下降(无症状,坏死,肥大,和心力衰竭)。使用众所周知的动物模型,UM-X7.1仓鼠HCM(HCMH),我们的结果显示,与年龄匹配的正常仓鼠(NH)相比,在HCMHs发生坏死前的无症状阶段,平均动脉压(MAP)没有变化.然而,在心力衰竭阶段,MAP逐渐下降,达到最低水平.在HCM坏死期发展过程中的MAP伴随着钠-氢交换剂水平的显着增加,NHE1.用有效的NHE1抑制剂治疗,EMD87580(利美伯胺),不影响NH的MAP。然而,在HCM发展的三个阶段,EMD87580治疗可显着逆转与HCM相关的低血压。我们的结果表明,HCM的发展与低血压有关。这些结果表明,血压下降可能是导致HF和早期死亡的HCM的生物标志物信号。由于NHE1的封锁显著但部分阻止了MAP的减少,这表明其他机制也可能导致HCM中低血压的发生.
It is well accepted that hypertension may lead to the development of heart failure (HF). However, little is known about the development of hypotension that may contribute to the onset of hereditary cardiomyopathy (HCM), thus promoting heart failure and early death. The purpose of this study is to verify whether a decrease in blood pressure takes place during different phases of HCM (asymptomatic, necrosis, hypertrophy, and heart failure). Using the well-known animal model, the UM-X7.1 hamster strain of HCM (HCMH), our results showed the absence of a change in mean arterial pressure (MAP) during the asymptomatic phase preceding the development of necrosis in HCMHs when compared to age-matched normal hamster (NH). However, there was a progressive decrease in MAP that reached its lowest level during the heart failure phase. The MAP during the development of the necrosis phase of HCM was accompanied by a significant increase in the level of the sodium-hydrogen exchanger, NHE1. Treatments with the potent NHE1 inhibitor, EMD 87580 (rimeporide), did not affect MAP of NH. However, treatments with EMD 87580 during the three phases of the development of HCM significantly reversed the hypotension associated with HCM.Our results showed that the development of HCM is associated with hypotension. These results suggest that a decrease in blood pressure could be a biomarker signal for HCM leading to HF and early death. Since the blockade of NHE1 significantly but partially prevented the reduction in MAP, this suggests that other mechanisms can contribute to the development of hypotension in HCM.