在精神分裂症患者中,大脑网络中的枢纽区域发生了改变。然而,目前尚不清楚,在具有精神分裂症亚临床特征(如社交快感缺失(SA))的个体中,是否会出现类似的大脑中枢区改变.在这项研究中,我们检查了35名SA参与者和50名健康对照(HC)参与者的静息状态社交脑网络(SBN)的中枢区域.我们进一步研究了具有SBN的集线器连接FC对现实生活中社交网络特征的预测效果。我们的发现表明右杏仁核,在SA和HC组中,左侧颞叶和右侧中额上回都是SBN的中心区域。在SA组中,左颞叶连接功能连接(FC)不能预测社交网络特征,而其他FC加强了与社交网络特征的关联。这些发现在33SA和32HC的独立样品中重复。这些发现表明,作为SBN枢纽区域之一的左颞叶在SA患者的社交网络特征相关方面表现出连接的FC异常。
Altered hub regions in brain network have been consistently reported in patients with schizophrenia. However, it is unclear whether similar altered hub regions of the brain would be exhibited in individuals with subclinical features of schizophrenia such as social anhedonia (SA). In this study, we examined the hub regions of resting-state social brain network (SBN) of 35 participants with SA and 50 healthy controls (HC). We further examined the prediction effect of hub-connected FCs with SBN on the real-life social network characteristics. Our findings showed that the right amygdala, left temporal lobe and right media superior frontal gyrus were the hub regions of SBN both in SA and HC groups. In the SA group, the left temporal lobe connected functional connectivity (FC) did not predict social network characteristics, while the other FCs strengthened the association with social network characteristics. These findings were replicated in an independent sample of 33 SA and 32 HC. These findings suggested that the left temporal lobe as one of the hub regions of SBN exhibited the abnormality of their connected FCs in the association with social network characteristics in individuals with SA.