人跟腱的特定粘弹性机械性能强烈依赖于胶原蛋白的结构特征。尽管对各种动物跟腱变形机制的研究是广泛的,对人类跟腱中这些机制的理解在很大程度上仍然是经验和宏观的。在这项工作中,D-空间的演化,定位,在拉伸过程中使用SAXS技术研究了纤维之间空隙的平均长度。最初,空隙长度略有增加,而随着D空间的稳步增加,定向错误的宽度迅速下降。在第二个地区,在应力上升的情况下,D空间和空隙长度急剧增加,即使方向错误宽度减小。在第三个地区,空隙长度和D空间的增加减速,但是方向错误的宽度变宽了,提示跟腱发生不可逆的显微原纤维衰竭。在最后一个地区,纤维经历宏观破坏,D空间和void长度返回到它们的初始状态。宏观变化由纳米级结构响应阐明,提供对驱动复杂生物力学的机制的基本理解,组织结构组织,跟腱再生。
The specific viscoelastic mechanical properties of the human Achilles tendon are strongly dependent on the structural characteristics of collagen. Although research on the deformation mechanisms of the Achilles tendon in various animals is extensive, understanding of these mechanisms in the human Achilles tendon remains largely empirical and macroscopic. In this work, the evolution of D-space, orientation, and average length of voids between fibers are investigated during the stretching using SAXS techniques. Initially, the void length increases marginally, while the misorientation breadth decreased rapidly as the D-space steadily increased. In the second region, D-space and the void length increase sharply under rising stress, even though misorientation width decreased. During the third region, the increases in void length and D-space decelerate, but the misorientation width widens, suggesting the onset of irreversible microscopic fibril failure in the Achilles tendon. In the final region, the fibers undergo macroscopic failure, with D-space and void length returning to their initial states. The macroscopic alterations are elucidated by the nanoscale structural responses, providing a fundamental understanding of the mechanisms driving the complex biomechanics, tissue structural organization, and Achilles tendon regeneration.