皮肤结核(CTB)和非结核分枝杆菌(NTM)感染提出了相当大的诊断和治疗挑战。这项研究旨在提供CTB和NTM感染的全面临床病理分析。
■我们对2000年1月至2024年1月在北京皮肤科诊断为皮肤结核(CTB)和非结核分枝杆菌(NTM)感染的103例患者进行了回顾性分析。人口统计,临床,组织学,并收集了实验室发现数据。记录诊断方法和组织病理学检查。回顾了治疗方案和结果。描述性统计用于总结人口统计学和临床数据,和连续变量表示为均值和标准差(SD),以及频率和百分比等分类变量。使用SPSS版本25.0进行统计分析。
■该队列包括103名患者(男性占40.8%,女性占59.2%),平均年龄51.86岁.常见的临床表现包括结节(97.1%),红斑(74.8%),和斑块(68.9%)。组织学检查显示角化过度(68.9%),角化不全(23.3%),观察到广泛的中性粒细胞浸润(95.1%)。抗酸细菌(AFB)染色和核酸检测的阳性率分别为39.6%和52.3%,分别。大多数患者接受了三种药物的联合治疗;77.1%的患者表现出改善,CTB治愈率为20.0%。
■这项研究强调了CTB和NTM感染的不同临床和组织学表现,强调需要全面的诊断方法。治疗方案的可变性反映了这些感染的复杂管理。
■实施先进的分子技术和标准化治疗方案对于提高诊断精度和治疗结果至关重要。
UNASSIGNED: Cutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections present considerable diagnostic and therapeutic challenges. This study aims to provide a comprehensive clinicopathological analysis of CTB and NTM infections.
UNASSIGNED: We conducted a retrospective analysis of 103 patients diagnosed with cutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections at a Beijing dermatology department from January 2000 to January 2024. Demographic, clinical, histological, and laboratory finding data were collected. Diagnostic methods and histopathological examination were recorded. Treatment regimens and outcomes were reviewed. Descriptive statistics were used to summarize demographic and clinical data, and continuous variables expressed as means and standard deviations (SD), and categorical variables as frequencies and percentages. Statistical analyses were conducted using SPSS version 25.0.
UNASSIGNED: The cohort included 103 patients (40.8% males and 59.2% females), with a mean age of 51.86 years. Common clinical manifestations included nodules (97.1%), erythema (74.8%), and plaques (68.9%). Histological examination revealed hyperkeratosis (68.9%), parakeratosis (23.3%), and extensive neutrophil infiltration (95.1%) were observed. Acid fast bacteria (AFB) stains and nucleic acid tests exhibited respective positivity rates of 39.6% and 52.3%, respectively. Most patients were treated with a combination of three drugs; 77.1% of patients showed improvement, with the cure rate for CTB being 20.0%.
UNASSIGNED: This study highlights the diverse clinical and histological presentations of CTB and NTM infections, emphasizing the need for comprehensive diagnostic approaches. The variability in treatment regimens reflects the complex management of these infections.
UNASSIGNED: The implementation of advanced molecular techniques and standardized treatment protocols is imperative for enhancing diagnostic precision and therapeutic outcomes.