背景:医用粘合剂相关的皮肤损伤可能来自局部应用的医疗设备,尤其是那些皮肤脆弱的人,包括老人和早产儿。这项研究的目的是比较两种脉搏血氧饱和度传感器(OxySoftN和MaxN,美敦力,博尔德,CO).
方法:18名年龄在65岁及以上的健康受试者参加温和试验,20名健康受试者(18-69岁)被纳入再应用试验。为了温柔的审判,在三个时间点,在每个前臂的五个部位进行表皮失水(TEWL)测量(基线[T0],初始磨损后4小时[T1],4小时后磨损[T2])。还测定粘附到每个装置的蛋白质的总量。对于重新申请审判,进行一系列180°剥离测试以观察将传感器与皮肤分离所需的力。
结果:与T1时的OxySoftN相比,MaxN在尾部区域的TEWL率明显更高(p<0.05)。两者均显著大于对照(p<0.05)。Further,蛋白质分析显示,与MaxN相比,OxySoftN去除的蛋白质量明显较少(p<0.0001)。证明了两个传感器之间尾部区域粘附力损失的差异,与MaxN相比,OxySoftN的折旧速度要慢得多。
结论:OxySoftN传感器似乎很温和,即使在脆弱的皮肤上,基于减少皮肤在去除过程中的应变。Further,它证明了承受多次重新应用的能力,而不会失去粘附力。
BACKGROUND: Medical Adhesive Related Skin Injuries can arise from topically applied medical devices, especially in those with fragile skin, including the elderly and premature infants. The purpose of this study was to compare gentleness and reapplication of two pulse oximetry sensors (OxySoftN and MaxN, Medtronic, Boulder, CO).
METHODS: Eighteen healthy subjects aged 65 years and older were enrolled in the gentleness trial, and 20 healthy subjects (18-69 years) were enrolled in the reapplication trial. For the gentleness trial, trans-epidermal water loss (TEWL) measurements were made at five sites on each forearm at three time points (baseline [T0], 4-h postinitial wear [T1], 4-h postsecond wear [T2]). Total amount of protein adhered to each device was also determined. For the reapplication trial, a series of 180° peel tests were performed to observe the forces required to detach the sensor from the skin.
RESULTS: TEWL rates in the tail region were significantly greater with MaxN compared to OxySoftN at T1 (p < 0.05). Both were significantly greater than control (p < 0.05). Further, protein analysis revealed that the amount of protein removed was significantly less with OxySoftN compared to MaxN (p < < 0.0001). Differences in loss of adhesion of the tail region between the two sensors were demonstrated, with OxySoftN depreciating at a much slower rate compared with MaxN.
CONCLUSIONS: The OxySoftN sensor appears to be gentle, even on fragile skin, based on reduced strain on the skin during removal. Further, it demonstrated the ability to withstand several reapplications without functional loss in adhesion.