Aiming at early detection and accurate prediction of cardiovascular disease (CVD) to reduce mortality rates, this study focuses on the development of an intelligent predictive system to identify individuals at risk of CVD. The primary objective of the proposed system is to combine deep learning models with advanced data mining techniques to facilitate informed decision-making and precise CVD prediction. This approach involves several essential steps, including the preprocessing of acquired data, optimized feature selection, and disease classification, all aimed at enhancing the effectiveness of the system. The chosen optimal features are fed as input to the disease classification models and into some Machine Learning (ML) algorithms for improved performance in CVD classification. The experiment was simulated in the Python platform and the evaluation metrics such as accuracy, sensitivity, and F1_score were employed to assess the models\' performances. The ML models (Extra Trees (ET), Random Forest (RF), AdaBoost, and XG-Boost) classifiers achieved high accuracies of 94.35%, 97.87%, 96.44%, and 99.00%, respectively, on the test set, while the proposed CardioVitalNet (CVN) achieved 87.45% accuracy. These results offer valuable insights into the process of selecting models for medical data analysis, ultimately enhancing the ability to make more accurate diagnoses and predictions.

BACKGROUND: Robust and accurate prediction of severity for patients with COVID-19 is crucial for patient triaging decisions. Many proposed models were prone to either high bias risk or low-to-moderate discrimination. Some also suffered from a lack of clinical interpretability and were developed based on early pandemic period data. Hence, there has been a compelling need for advancements in prediction models for better clinical applicability.
OBJECTIVE: The primary objective of this study was to develop and validate a machine learning-based Robust and Interpretable Early Triaging Support (RIETS) system that predicts severity progression (involving any of the following events: intensive care unit admission, in-hospital death, mechanical ventilation required, or extracorporeal membrane oxygenation required) within 15 days upon hospitalization based on routinely available clinical and laboratory biomarkers.
METHODS: We included data from 5945 hospitalized patients with COVID-19 from 19 hospitals in South Korea collected between January 2020 and August 2022. For model development and external validation, the whole data set was partitioned into 2 independent cohorts by stratified random cluster sampling according to hospital type (general and tertiary care) and geographical location (metropolitan and nonmetropolitan). Machine learning models were trained and internally validated through a cross-validation technique on the development cohort. They were externally validated using a bootstrapped sampling technique on the external validation cohort. The best-performing model was selected primarily based on the area under the receiver operating characteristic curve (AUROC), and its robustness was evaluated using bias risk assessment. For model interpretability, we used Shapley and patient clustering methods.
RESULTS: Our final model, RIETS, was developed based on a deep neural network of 11 clinical and laboratory biomarkers that are readily available within the first day of hospitalization. The features predictive of severity included lactate dehydrogenase, age, absolute lymphocyte count, dyspnea, respiratory rate, diabetes mellitus, c-reactive protein, absolute neutrophil count, platelet count, white blood cell count, and saturation of peripheral oxygen. RIETS demonstrated excellent discrimination (AUROC=0.937; 95% CI 0.935-0.938) with high calibration (integrated calibration index=0.041), satisfied all the criteria of low bias risk in a risk assessment tool, and provided detailed interpretations of model parameters and patient clusters. In addition, RIETS showed potential for transportability across variant periods with its sustainable prediction on Omicron cases (AUROC=0.903, 95% CI 0.897-0.910).
CONCLUSIONS: RIETS was developed and validated to assist early triaging by promptly predicting the severity of hospitalized patients with COVID-19. Its high performance with low bias risk ensures considerably reliable prediction. The use of a nationwide multicenter cohort in the model development and validation implicates generalizability. The use of routinely collected features may enable wide adaptability. Interpretations of model parameters and patients can promote clinical applicability. Together, we anticipate that RIETS will facilitate the patient triaging workflow and efficient resource allocation when incorporated into a routine clinical practice.

Depression is a global concern, with a significant number of people affected worldwide, particularly in low- and middle-income countries. The rising prevalence of depression emphasizes the importance of early detection and understanding the origins of such conditions.
This paper proposes a framework for detecting depression using a hybrid visualization approach that combines local and global interpretation. This approach aims to assist in model adaptation, provide insights into patient characteristics, and evaluate prediction model suitability in a different environment.
This study utilizes R programming language with the Caret, ggplot2, Plotly, and Dalex libraries for model training, visualization, and interpretation. Data from the NHANES repository was used for secondary data analysis. The NHANES repository is a comprehensive source for examining health and nutrition of individuals in the United States, and covers demographic, dietary, medication use, lifestyle choices, reproductive and mental health data. Penalized logistic regression models were built using NHANES 2015-2018 data, while NHANES 2019-March 2020 data was used for evaluation at the global-specific and local level interpretation.
The prediction model that supports this framework achieved an average AUC score of 0.748 (95% CI: 0.743-0.752), with minimal variability in sensitivity and specificity.
The built-in prediction model highlights chest pain, the ratio of family income to poverty, and smoking status as crucial features for predicting depressive states in both the original and local environments.

The demand for food delivery services (FDSs) during the COVID-19 crisis has been fuelled by consumers who prefer to order meals online and have it delivered to their door than to wait at a restaurant. Since many restaurants moved online and joined FDSs such as Uber Eats, Menulog, and Deliveroo, customer reviews on internet platforms have become a valuable source of information about a company\'s performance. FDS organisations strive to collect customer complaints and effectively utilise the information to identify improvements needed to enhance customer satisfaction. However, only a few customer opinions are addressed because of the large amount of customer feedback data and lack of customer service consultants. Organisations can use artificial intelligence (AI) instead of relying on customer service experts and find solutions on their own to save money as opposed to reading each review. Based on the literature, deep learning (DL) methods have shown remarkable results in obtaining better accuracy when working with large datasets in other domains, but lack explainability in their model. Rapid research on explainable AI (XAI) to explain predictions made by opaque models looks promising but remains to be explored in the FDS domain. This study conducted a sentiment analysis by comparing simple and hybrid DL techniques (LSTM, Bi-LSTM, Bi-GRU-LSTM-CNN) in the FDS domain and explained the predictions using SHapley Additive exPlanations (SHAP) and Local Interpretable Model-Agnostic Explanations (LIME). The DL models were trained and tested on the customer review dataset extracted from the ProductReview website. Results showed that the LSTM, Bi-LSTM and Bi-GRU-LSTM-CNN models achieved an accuracy of 96.07%, 95.85% and 96.33%, respectively. The model should exhibit fewer false negatives because FDS organisations aim to identify and address each and every customer complaint. The LSTM model was chosen over the other two DL models, Bi-LSTM and Bi-GRU-LSTM-CNN, due to its lower rate of false negatives. XAI techniques, such as SHAP and LIME, revealed the feature contribution of the words used towards positive and negative sentiments, which were used to validate the model.

During the COVID-19 crisis, customers\' preference in having food delivered to their doorstep instead of waiting in a restaurant has propelled the growth of food delivery services (FDSs). With all restaurants going online and bringing FDSs onboard, such as UberEATS, Menulog or Deliveroo, customer reviews on online platforms have become an important source of information about the company\'s performance. FDS organisations aim to gather complaints from customer feedback and effectively use the data to determine the areas for improvement to enhance customer satisfaction. This work aimed to review machine learning (ML) and deep learning (DL) models and explainable artificial intelligence (XAI) methods to predict customer sentiments in the FDS domain. A literature review revealed the wide usage of lexicon-based and ML techniques for predicting sentiments through customer reviews in FDS. However, limited studies applying DL techniques were found due to the lack of the model interpretability and explainability of the decisions made. The key findings of this systematic review are as follows: 77% of the models are non-interpretable in nature, and organisations can argue for the explainability and trust in the system. DL models in other domains perform well in terms of accuracy but lack explainability, which can be achieved with XAI implementation. Future research should focus on implementing DL models for sentiment analysis in the FDS domain and incorporating XAI techniques to bring out the explainability of the models.

In the field of landscape epidemiology, the contribution of machine learning (ML) to modeling of epidemiological risk scenarios presents itself as a good alternative. This study aims to break with the \"black box\" paradigm that underlies the application of automatic learning techniques by using SHAP to determine the contribution of each variable in ML models applied to geospatial health, using the prevalence of hookworms, intestinal parasites, in Ethiopia, where they are widely distributed; the country bears the third-highest burden of hookworm in Sub-Saharan Africa. XGBoost software was used, a very popular ML model, to fit and analyze the data. The Python SHAP library was used to understand the importance in the trained model, of the variables for predictions. The description of the contribution of these variables on a particular prediction was obtained, using different types of plot methods. The results show that the ML models are superior to the classical statistical models; not only demonstrating similar results but also explaining, by using the SHAP package, the influence and interactions between the variables in the generated models. This analysis provides information to help understand the epidemiological problem presented and provides a tool for similar studies.

[This corrects the article DOI: 10.3389/fpubh.2021.675766.].

The Severe Acute Respiratory Syndrome Coronavirus 2 pandemic has challenged medical systems to the brink of collapse around the globe. In this paper, logistic regression and three other artificial intelligence models (XGBoost, Artificial Neural Network and Random Forest) are described and used to predict mortality risk of individual patients. The database is based on census data for the designated area and co-morbidities obtained using data from the Ontario Health Data Platform. The dataset consisted of more than 280,000 COVID-19 cases in Ontario for a wide-range of age groups; 0-9, 10-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89, and 90+. Findings resulting from using logistic regression, XGBoost, Artificial Neural Network and Random Forest, all demonstrate excellent discrimination (area under the curve for all models exceeded 0.948 with the best performance being 0.956 for an XGBoost model). Based on SHapley Additive exPlanations values, the importance of 24 variables are identified, and the findings indicated the highest importance variables are, in order of importance, age, date of test, sex, and presence/absence of chronic dementia. The findings from this study allow the identification of out-patients who are likely to deteriorate into severe cases, allowing medical professionals to make decisions on timely treatments. Furthermore, the methodology and results may be extended to other public health regions.