■胶质纤维酸性蛋白作为星形胶质损伤的生物标志物,特别是严重的创伤性脑损伤。本研究旨在评估严重创伤性脑损伤患者前3天内血清胶质纤维酸性蛋白水平的变化及其与预后的相关性。
■39例重型颅脑损伤患者被纳入研究。他们的血液样本是在六个不同的时间点收集的:T0(入院时),T1、T2、T3、T4和T5(6-,12-,24-,48-,入学后72小时,分别)。运行血液样品以定量血清神经胶质原纤维酸性蛋白水平和其他生化测试。密切关注所有患者,并评估出院时的结果。
■从入院到入院后48h,胶质纤维酸性蛋白水平趋于逐渐升高,然后在入院后72h降低。神经胶质纤维酸性蛋白T2与急性生理和慢性健康评价Ⅱ评分相关,乳酸,简化急性生理学评分II评分和结果。神经胶质纤维酸性蛋白max与乳酸相关,急性生理学和慢性健康评估II评分,简化急性生理学评分II评分,和结果。入院时格拉斯哥昏迷评分和胶质纤维酸性蛋白T2(OR=1.034;p=0.025),T3(OR=1.029;p=0.046),T4(OR=1.006;p=0.032),T5(OR=1.012;p=0.048)和胶质纤维酸性蛋白max(OR=1.005;p=0.010)是影响重型颅脑损伤患者预后的独立因素。根据胶质纤维酸性蛋白T2和格拉斯哥昏迷评分T0预测死亡率的预测模型曲线下面积最大,曲线下面积为0.904,p<0.001。在多元回归模型中,胶质纤维酸性蛋白max与格拉斯哥评分相关(p<0.001;VIF=1.585),乳酸T0(p=0.024;VIF=1.163),急性生理学和慢性健康评估II评分(p=0.037;VIF=1.360),和鹿特丹评分(p=0.044;VIF=1.713)。
■从入院到入院后48小时,胶质纤维酸性蛋白水平趋于逐渐升高,然后在入院后72小时降低。胶质纤维酸性蛋白T2、T3、T4、T5和胶质纤维酸性蛋白max是影响重型颅脑损伤患者预后死亡的独立因素。
UNASSIGNED: Glial fibrillary acidic protein serves as a biomarker indicative of astroglial injury, particularly following instances of severe traumatic brain injury. This study aims to evaluate variations in serum glial fibrillary acidic protein levels within the first 3 days and their correlation with outcomes in patients with severe traumatic brain injury.
UNASSIGNED: Thirty-nine patients with severe traumatic brain injury were enrolled in the study. Their blood samples were collected at six distinct time points: T0 (upon admission), T1, T2, T3, T4, and T5 (6-, 12-, 24-, 48-, and 72-h post-admission, respectively). The blood samples were run for the quantification of serum glial fibrillary acidic protein levels and other biochemical tests. All patients were closely watched and the outcomes at discharge were evaluated.
UNASSIGNED: Glial fibrillary acidic protein levels tend to increase gradually from the time of admission to 48 h post-admission and then decrease at 72 h post-admission. Glial fibrillary acidic protein T2 is correlated with Acute Physiology and Chronic Health Evaluation II score, lactate, Simplified Acute Physiology Score II score and outcome. Glial fibrillary acidic protein max correlated with lactate, Acute Physiology and Chronic Health Evaluation II score, Simplified Acute Physiology Score II score, and outcome. Glasgow Coma Score at admission and glial fibrillary acidic protein T2 (OR = 1.034; p = 0.025), T3 (OR = 1.029; p = 0.046), T4 (OR = 1.006; p = 0.032), T5 (OR = 1.012; p = 0.048) and glial fibrillary acidic protein max (OR = 1.005; p = 0.010) were independent factors that have significant prognostic value in mortality in patients with severe traumatic brain injury. The predictive model in predicting mortality had the highest area under the curve based on glial fibrillary acidic protein T2 and Glasgow Coma Score T0 with an area under the curve of 0.904 and p < 0.001. In the multivariable regression model, glial fibrillary acidic protein max was associated with Glasgow score (p < 0.001; VIF = 1.585), lactate T0 (p = 0.024; VIF = 1.163), Acute Physiology and Chronic Health Evaluation II score (p = 0.037; VIF = 1.360), and Rotterdam score (p = 0.044; VIF = 1.713).
UNASSIGNED: Glial fibrillary acidic protein levels tend to increase gradually from the time of admission to 48 h post-admission then decreases at 72 h post-admission. Glial fibrillary acidic protein T2, T3, T4, T5, and glial fibrillary acidic protein max were independent factors with significant prognostic mortality values in patients with severe traumatic brain injury.