从植物来源中寻找新的生物活性化合物一直是并将继续是药物发现中最重要的研究领域之一。然而,天然产物研究不断发展,越来越多的人具有多学科的特点。尽管方法和概念有了新的发展,一个有趣的方面仍然存在,即,属于同一属的不同物种可以产生不同的次生代谢产物,而分类学上不同的属可以产生相同的化合物。SalviaL.属(唇形科)包括世界范围内传统医学中使用的无数不同的草药,由于存在各种有趣的专门代谢产物,它们显示出不同的药理活性。包括mono-,sesqui-,di-,塞斯特-,三-,四-,和高级萜类化合物以及苯丙素化合物,酚酸衍生物,木脂素,黄酮类化合物,和生物碱。我们在此总结了一些不常见萜类化合物的研究进展,从丹参属的成员中分离出来,它们的潜在药理活性是公认的。这篇综述还提供了有关丹参物种中一些有趣的植物化学物质的生物合成和发生的最新知识,viz.C23-萜类化合物,类黄酮(C25),达玛烷三萜类化合物(C30),和不常见的三萜类化合物(C20+C10)。这项研究是通过搜索各种科学数据库来进行的,包括Elsevier,ACS出版物,泰勒和弗朗西斯,Wiley在线图书馆,MDPI,Springer,Thieme,和ProQuest。因此,识别并总结了106种不常见的萜类化合物。其中一些化合物具有多种药理特性,如抗菌,抗病毒,抗寄生虫,细胞毒性和微管蛋白酪氨酸连接酶抑制活性。由于缺乏从以前的研究中收集到的化合物的药理学信息,应该重新研究这些化合物的生物学研究。
The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus Salvia L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus Salvia, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from Salvia species, viz. C23-terpenoids,
sesterterpenoids (C25), dammarane triterpenoids (C30), and uncommon triterpenoids (C20+C10). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated.