随着2019年冠状病毒病(COVID-19)大流行期间学校的重新开放,必须了解学生和教育专业人员在严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)传播中的作用.在本文中,我们确定了CampoGrande学校社区中SARS-CoV-2抗核衣壳抗体的血清阳性率,南马托格罗索州(巴西)的首府和人口最多的城市,并评估了其与性别的关系,学校水平,和学校类型。
这项调查是使用免疫生物技术研究所的TRDPP®COVID-19免疫球蛋白M/免疫球蛋白G(IgM/IgG)试剂盒在CampoGrande城市地区的20所公立和私立学校中进行的(Bio-Manguinhos,里约热内卢,巴西)。测试分三个阶段进行:2021年10月至12月;2022年3月至7月;2022年8月至11月。参与者是小学或中学的6-17岁学生以及不同年龄和角色的专业人员。
在第一个测试期间,162名参与者的IgM和/或IgG抗核衣壳SARS-CoV-2抗体呈血清阳性,使用贝叶斯多水平回归估计血清阳性率为19.6%。在第二阶段,251名参与者血清呈阳性(估计血清阳性率,34.6%),而在第三阶段,393名参与者血清转换(估计血清阳性率,56.7%)。2022年,与2021年相比,血清转化率有所上升。这三个时期最常见的急性表现是发烧,头痛,喉咙痛,流鼻涕.就人口统计而言,两性之间没有明显的血清阳性,尽管女性约占研究人群的70%。学生和学校工作人员之间也没有差异。
这些结果使我们能够通过对SARS-CoV-2病毒的免疫来评估学校社区传播的程度,除了提供有关儿童COVID-19症状的信息外,青少年,和成年人。
With the reopening of schools during the coronavirus disease 2019 (COVID-19) pandemic, it was imperative to understand the role of students and education professionals in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this paper, we determined the seroprevalence of the SARS-CoV-2 anti-nucleocapsid antibodies in the school community in Campo Grande, the capital and most populous city of the state of Mato Grosso do Sul (Brazil) and evaluated its association with sex, school level, and school type.
The survey was carried out in 20 public and private schools in the urban region of Campo Grande using the TR DPP® COVID-19 immunoglobulin M/immunoglobulin G (IgM/IgG) kit from the Immunobiological Technology Institute (Bio-Manguinhos, Rio de Janeiro, Brazil). Testing was carried out in three periods: from October to December 2021; from March to July 2022; and from August to November 2022. The participants were students aged 6-17 years enrolled in primary or secondary schools and professionals of different ages and roles.
During the first testing period, 162 participants were seropositive for the IgM and/or IgG anti-nucleocapsid SARS-CoV-2 antibodies, with an estimated seroprevalence of 19.6% using Bayesian multilevel regression. In the second period, 251 participants were seropositive (estimated seroprevalence, 34.6%), while in the third period, 393 participants were seroconverted (estimated seroprevalence, 56.7%). In 2022, there was an increase in the seroconversion rate compared to that in 2021. The most frequently described acute manifestations in the three periods were fever, headache, sore throat, and runny nose. In terms of the demographic profile, there was no predominance of seropositivity between the sexes, although women represented approximately 70% of the study population. There were also no differences between students and school staff.
The results made it possible to evaluate the extent of SARS-CoV-2 transmission in the school community through immunity developed against the virus, in addition to providing information about COVID-19 symptoms in children, adolescents, and adults.