背景:弓形虫病因与社会经济脆弱性和生活条件不足直接相关而引起公共卫生关注。
方法:因此,本研究旨在评估针对弓形虫的抗体,Pinhais历史报道的弓形虫病病例和相关的社会环境危险因素,一个完整的库里蒂巴市区,目前是巴西第八大都市区。通过间接免疫荧光反应(RFI)评估抗弓形虫抗体。还通过IFAT对主人和狗样品进行了抗利什曼原虫的测试。和抗克氏锥虫抗体。
结果:总体而言,来自25个不同家庭的20/135(14.8%)人和13/133(9.8%)犬被认为是弓形虫血清阳性。所有样品均对利什曼原虫属血清阴性。和克氏锥虫.
结论:尽管在回归模型中没有发现显著的协变量,双变量分析中的统计学相关风险因素包括业主不使用公共水(p=0.016)和饮用生牛奶(p=0.041),和肥胖(p=0.028)和蜱侵扰(p=0.03)的狗。此外,主人和他们的狗的弓形虫血清阳性的空间集群与历史报道的人类获得性病例的位置重叠,妊娠和先天性弓形虫病。最后,本文的结果表明,tick虫侵染是家庭环境中弓形虫暴露的社会环境风险指标,和狗可以用作人类弓形虫病的前哨。
BACKGROUND: Toxoplasmosis has been of public health concern due to direct associations with socioeconomic vulnerability and inadequate living conditions.
METHODS: Accordingly, the present study aimed to assess antibodies against T. gondii, historical reported toxoplasmosis cases and associated socio-environmental risk factors in Pinhais, a full urban area of Curitiba, currently the eighth biggest metropolitan area of Brazil. Anti-Toxoplasma gondii antibodies were assessed by an indirect immunofluorescence reaction (RIFI). Owner and dog samples were also tested by IFAT to anti-Leishmania spp. and anti-Trypanosoma cruzi antibodies.
RESULTS: Overall, 20/135 (14.8%) persons and 13/133 (9.8%) dogs from 25 different households were considered seropositive to T. gondii. All samples were seronegative to Leishmania spp. and Trypanosoma cruzi.
CONCLUSIONS: Although no significant covariates were found in the regression model, statistically associated risk factors in the bivariate analysis included no public water use (p = 0.016) and drinking raw milk (p = 0.041) for owners, and obesity (p = 0.028) and tick infestation (p = 0.03) for dogs. In addition, a spatial cluster of T. gondii seropositivity for both owners and their dogs overlapped the location of historic reported cases of human acquired, gestational and congenital toxoplasmosis. Finally, the results herein showed tick infestation as an indicator of socio-environmental risk for T. gondii exposure in the household environment, and dogs may be used as sentinels for human toxoplasmosis cases.