联合国:为了对抗梅毒发病率的上升,巴西卫生部(MoH)启动了“梅毒编号!”项目(SNP),由议会修正案资助的特定资源。然后,2018年,巴西统一卫生系统开始实施国家快速反应(SUS,SistemaónicodeSaúde)在两个战略路线中(1)加强SUS的普遍行动,以及(2)对卫生部选择的100个城市实施特定行动,作为梅毒先天性反应的优先事项。2015年,这些地区占巴西先天性梅毒病例的6895%。在这种情况下,SNP已采取行动,通过卫生服务网络和加强州际关系,采取综合和协作对策,加强对获得性梅毒和先天性梅毒的流行病学监测。
UNASSIGNED:进行了一项使用时间序列分析的准实验研究,以评估项目前后对国家先天性梅毒趋势的直接影响和变化,从2016年9月到2019年12月。评估数据时考虑了该项目涵盖的所有优先城市(n=100)和巴西所有五个宏观区域的非优先城市(n=5,470)中每1,000名活产先天性梅毒的发生率。
UNASSIGNED:与非优先城市相比,优先城市显示出更大的减少(趋势变化)。线性回归模型显示干预后的趋势变化,两组城市的平均每月每千名活产病例数都有所下降,在优先城市中减少-0·21(CI95%-0·33至-0·09;p=0·0011),在非优先城市中减少-0·10(CI95%-0.19至-0.02;p=0·0216)。
UNASSIGNED:使用ITS的研究提供了有关方向的重要证据,定时,以及作为SNP一部分引入的干预措施对巴西先天性梅毒的影响程度。我们的结果表明,从2018年开始,梅毒项目影响了巴西先天性梅毒的趋势,优先城市的减少幅度更大。
UNASSIGNED:该研究由巴西卫生部资助的梅毒项目(项目编号:54/2017)。资助者在研究设计中没有作用,分析,决定发布,或准备手稿。
UNASSIGNED: To fight against the rising incidence of syphilis, the Brazilian Ministry of Health (MoH) launched the \"Syphilis No!\" Project (SNP), with specific resources funded by a parliamentary amendment. Then, in 2018, a national rapid response started to be implemented on the Brazilian Unified Health System (SUS, Sistema Único de Saúde) in two strategic lines (1) to reinforce SUS\'s universal actions and (2) to implement specific ones to 100 municipalities chosen by the MoH as priorities for syphilis congenital response. In 2015, such localities represented 6895% of congenital syphilis cases in Brazil. In this context, SNP has implemented actions to strengthen epidemiological surveillance of acquired syphilis and congenital syphilis by instituting an integrated and collaborative response through health services networks and reinforcing interstate relations.
UNASSIGNED: A quasi-experimental study using time series analysis was conducted to assess immediate impacts and changes to the trend in national congenital syphilis before and after the project, from September 2016 to December 2019. Data were assessed considering rates of congenital syphilis per 1,000 live births in all priority municipalities (n=100) covered by the project and in non-priority municipalities (n=5,470) from all five macro-regions of Brazil.
UNASSIGNED: Priority municipalities showed a greater reduction (change in trend) in comparison to non-priority. The linear regression model revealed trend changes after the intervention, with both groups of municipalities showing a drop in the average monthly number of cases per 1,000 live births, with a reduction of -0·21 (CI 95% -0·33 to -0·09; p=0·0011) in priority municipalities and of -0·10 (CI 95% -0.19 to -0.02; p=0·0216) in non-priority municipalities.
UNASSIGNED: The study using ITS provides important evidence on the direction, timing, and magnitude of the effects of interventions introduced as part of the SNP on congenital syphilis in Brazil. Our results suggest that the Syphilis No! Project influenced the trends of congenital syphilis in Brazil from 2018, with higher reductions achieved in the priority municipalities.
UNASSIGNED: The research is funded by a grant to the Syphilis No! Project from Brazilian Ministry of Health (Project Number: 54/2017). The funders had no role in study design, analysis, decision to publish, or preparation of the manuscript.