背景:临床上,大多数卡波西肉瘤(KS)患者是男性,几种直接和间接的机制可能是男性易感性增加的基础,卡波西肉瘤相关疱疹病毒(KSHV),也被称为人类疱疹病毒8(HHV-8),被认为是导致KS的主要病因。因此,我们提出了男性更容易感染HHV-8的假设,导致男性卡波济肉瘤发病率较高。进行了荟萃分析,以评估一般人群中性别与HHV-8血清阳性之间的关系。
方法:使用6个在线数据库进行了全面的文献检索:PubMed,EMBASE,科克伦图书馆,WebofScience,CNKI,还有万方。包括2023年3月15日之前发表的研究。
结果:总而言之,包括41项研究在内的33篇文章被纳入荟萃分析。在包括的成年人口中。在世界各地的成年人群中,男性感染HHV-8的风险高于女性(比值比[OR]:1.08,95%置信区间[CI]:1.01-1.15),但在世界各地的儿童人口中没有发现差异(OR:0.90,95%CI:0.79-1.01).在撒哈拉以南非洲(SSA)成年人口中,男女HHV-8血清阳性率存在显着差异(OR:1.15,95%CI:1.05-1.26)。然而,在撒哈拉以南非洲(SSA)儿童人群中没有观察到显著差异(OR:0.90,95CI0.78-1.03).至于其他大陆,结果没有显着差异,例如亚洲人口(OR:1.03,95CI:0.92-1.16)。或欧洲和美国人口(OR1.01,95CI0.87-1.17)。
结论:成人人群中HHV-8感染有轻微的性别差异。在来自SSA和全球的成年人口中,男性比女性更容易感染HHV-8.然而,在来自SSA和全球的儿童人群中未观察到统计学意义.在未来,纳入更多标准化研究可能会加强本研究的结果.
BACKGROUND: Clinically, most patients with Kaposi\'s sarcoma (KS) are male, and several direct and indirect mechanisms may underlie this increased susceptibility in men, Kaposi\'s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is considered to be the primary etiological agent responsible for KS. Thus, we propose the hypothesis that men are more susceptible to HHV-8 infection, leading to a higher incidence of Kaposi\'s sarcoma among males. A meta-analysis was conducted to evaluate the association between gender and HHV-8 seropositivity in the general population.
METHODS: A comprehensive literature search was performed using 6 online databases: PubMed, EMBASE, Cochrane library, Web of Science, CNKI, and Wanfang. Studies published before March 15, 2023, were included.
RESULTS: In all, 33 articles including 41 studies were included in the meta-analysis. In the included adult population. men had a higher risk of HHV-8 infection than did women in adult populations from all over the world (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.01-1.15), but no differences were found in child population from all over the world (OR: 0.90, 95% CI: 0.79-1.01). There was a significant difference in HHV-8 seroprevalence between men and women in sub-Saharan Africa (SSA) adult population (OR: 1.15, 95% CI: 1.05-1.26). However, no significant differences were observed in sub-Saharan Africa (SSA) child population (OR: 0.90, 95%CI 0.78-1.03). As for other continents, the results showed no significant difference, such as the Asian population (OR: 1.03, 95%CI: 0.92-1.16). or the European and American populations (OR 1.01, 95%CI 0.87-1.17).
CONCLUSIONS: There was a slight gender disparity for HHV-8 infection in the adult population. Among the adult populations from SSA and globally, men were more likely to be infected with HHV-8 than were women. However, no statistical significance was observed in the child populations from SSA and globally. In the future, the inclusion of more standardized studies may strengthen the results of this study.