非癫痫发作性事件(NEPE)是小儿年龄的常见临床表现,表现为模仿癫痫发作特征的运动和行为活动功能障碍。
提供并分析一组患有各种类型NEPE的儿童/青少年的数量和临床特征;比较该组受NEPE影响的儿童/青少年与一组受癫痫发作(ES)影响的儿童/青少年的临床数据。
这项回顾性研究是在卡塔尼亚大学儿科诊所进行的,卡塔尼亚,意大利,在2005年1月和2018年1月期间。两组儿童/青少年,年龄从1个月到15岁,被选中:312名受NEPE影响,192名受ES影响。报告了单一类型NEPE的数量和百分比。然后,人口特征,临床表现,事件的持续时间,诊断时间,分析并比较了每种类型的NEPE和ES受影响的儿童/青少年的发病年龄。数据的统计分析结果是在ES和某些类型的NEPE之间进行的,包括Sandifer综合征,屏住呼吸的法术,阵发性震颤,眩晕,和晕厥。
在NEPE集团中,眩晕,临床上无法分类的阵发性事件类型,晕厥,和Sandifer综合征是最常见的事件;在比较分析的样本中,在阵发性事件的持续时间中发现NEPE和ES之间的差异,在剧集数量上,在症状发作和诊断之间的滞后时间,和发病年龄。分析具有某种类型NEPE的ES的临床数据,在眩晕的持续时间和平均持续时间事件方面获得了统计学上显著的结果,在阵发性震颤中,作为事件的数量,在Sandifer综合征中作为诊断的滞后时间,最后在所有类型的NEPE中,关于发病年龄,和失去知觉。
分析每种类型的NEPE与ES的临床特征差异。然而,全球认为NEPE和ES之间的诊断差异仍然很困难,可疑,如果没有正确的父母报告的支持,是无法实现的,直接临床观察,和视频脑电图监测。
Non-Epileptic Paroxysmal Events (NEPE) are common clinical manifestations in pediatric age presenting with dysfunction of motor and behavioral activity mimicking features of epileptic seizures.
To present and analyze number and clinical characteristic of a group of children/adolescents presenting with various types of NEPE; to compare clinical data of this group of NEPE affected children/adolescents with a group of children/adolescents affected by Epileptic Seizures (ES).
The retrospective study was conducted at the Pediatric Clinic of University of Catania, Catania, Italy, in a period ranging from January 2005 and January 2018. Two groups of children/adolescents, aged from 1 month to 15 years, were selected: 312 affected by NEPE and 192 by ES. Number and percentage of the single type of NEPE were reported. Then, demographic characteristics, clinical manifestations, duration of the events, time of diagnosis, and age of onset of each type of NEPE and ES affected children/adolescents were analyzed and compared. Results of statistical analysis of the data were carried out between ES and some type of NEPEs including Sandifer syndrome, breath-holding spells, paroxysmal tremors, vertigo, and syncope.
Among the group of NEPE, vertigo, type of paroxysmal event clinically not classifiable, syncope, and Sandifer syndrome were the most common events; In the comparative analyzed samples, variability between NEPE and ES was found in the duration of the paroxysmal events, in number of episodes, in lag-time between the onset of symptoms and the diagnosis, and in age of onset. Analyzing clinical data of ES with some type of NEPE, statistical significant results were obtained in vertigo as regards the duration and average duration event, in paroxysmal tremors as number of events, in Sandifer syndrome as lag-time of diagnosis, and finally in all the types of NEPE as regards the age of onset, and loss of consciousness.
Analyzing the clinical features of each type of NEPE differences with ES are found. However, globally considered diagnostic differences between NEPE and ES remain difficult, questionable, and unrealizable without the support of correct parental report, direct clinical observations, and video-EEG monitoring.