UNASSIGNED:唾液腺癌(SGC)相对罕见,并构成多种组织学亚型。先前发表的对SGC患者的研究表明,使用常规放射疗法(RT)或3维(3D)适形放射疗法的术后放射可能导致肿瘤学结果欠佳。
UNASSIGNED:我们确定了60例主要SGC患者接受手术治疗,然后接受术后调强放疗(IMRT)。总生存期(OS)数据,无进展生存期(PFS),局部无复发生存率(LRRFS),无远处转移生存期(DMFS),预后因素,并对治疗相关毒性进行分析。使用Kaplan-Meier方法分析生存并使用对数秩检验进行比较。
未经评估:中位随访时间为55.5个月,基于Kaplan-Meier分析,SGC患者3年、5年和10年的OS和PFS率为90.7%,85.1%,85.1%和80.1%,72.7%,和63.1%,分别。3年、5年和10年的LRFS和DMFS率为87.4%,82.1%,82.1%和85.3%,78.4%,和66.1%,分别。在多变量分析(MVA)中,节点分期(N分期)是PFS的独立预测因子[P=0.047;风险比(HR)=0.089].阳性切缘是PFS的重要预后因素(P=0.036;HR=4.086),LRFS(P=0.026;HR=5.064),和DMFS(P=0.011;HR=6.367)。主要神经受累与PFS(P=0.034;HR=2.394)和DMFS(P=0.008;HR=2.115)显着相关。从手术到放疗的时间间隔可预测PFS(P=0.036;HR=3.934)和DMFS(P=0.012;HR=6.231)。腺样囊性癌(ACC)是最常见的组织学(n=21;35%)。对于ACC,5年OS,PFS,LRRFS,DMFS是100%,67.7%,76.2%,90.2%,分别。最常见的急性毒性是粘膜炎和皮炎,口干症是最常见的晚期不良事件。肺转移是最常见的远处衰竭模式。
未经评估:N阶段,正利润率,主要神经受累,手术到放疗的间隔时间是影响PFS的重要因素,LRRFS,和DMFS。术后IMRT可改善SGC患者的生存率,可接受的毒性。
UNASSIGNED: Salivary gland cancer (SGC) is relatively rare and constitutes a variety of histological subtypes. Previously published studies of SGC patients suggest that postoperative radiation using conventional radiotherapy (RT) or 3-dimensional (3D) conformal radiotherapy may have led to suboptimal oncological outcomes.
UNASSIGNED: We identified 60 patients with major SGC treated with surgery followed by postoperative intensity-modulated radiotherapy (IMRT). Data for overall survival (OS), progression-free survival (PFS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), prognostic factors, and treatment-related toxicities were analyzed. Survival was analyzed using the Kaplan-Meier method and compared using the log-rank test.
UNASSIGNED: With a median follow-up of 55.5 months, based on Kaplan-Meier analyses, the OS and PFS rates for SGC patients at 3, 5, and 10 years were 90.7%, 85.1%, and 85.1% and 80.1%, 72.7%, and 63.1%, respectively. The LRRFS and DMFS rates at 3, 5, and 10 years were 87.4%, 82.1%, and 82.1% and 85.3%, 78.4%, and 66.1%, respectively. In multivariable analysis (MVA), the node stage (N stage) was an independent predictor of PFS [P=0.047; hazard ratio (HR) =0.089]. A positive margin was a significant prognostic factor for PFS (P=0.036; HR =4.086), LRRFS (P=0.026; HR =5.064), and DMFS (P=0.011; HR =6.367). Major nerve involvement was significantly correlated with PFS (P=0.034; HR =2.394) and DMFS (P=0.008; HR =2.115). The interval from surgery to radiotherapy predicted PFS (P=0.036; HR =3.934) and DMFS (P=0.012; HR =6.231). Adenoid cystic carcinoma (ACC) was the most common histology (n=21; 35%). For ACC, the 5-year OS, PFS, LRRFS, and DMFS were 100%, 67.7%, 76.2%, and 90.2%, respectively. The most common acute toxicities were mucositis and dermatitis, and xerostomia was the most common late adverse event. Lung metastasis was the most common pattern of distant failure.
UNASSIGNED: N stage, positive margin, major nerve involvement, and interval from surgery to radiotherapy were important factors associated with PFS, LRRFS, and DMFS. Postoperative IMRT leads to improved survival for SGC patients, with acceptable toxicities.