目的:在本研究中,我们利用文献计量学方法评估了2014-2022年全球科学产出,并确定了与体积调节阴离子通道(VRAC)研究相关的热点.方法:来自WebofScience,我们获得了2014年至2022年发表的与VRAC相关的研究。为了分析数据,我们利用了VOSviewer,一个可视化网络的工具,建立基于国家间合作的网络,机构,和作者。此外,我们对期刊共同引用进行了分析,文件引用,和共同出现的关键字。此外,我们使用了CiteSpace(6.1。R6Advanced)以最强的爆发分析关键字和共同引用的参考文献。结果:最终分析共纳入278篇相关文章和综述,涵盖2014年至2022年期间。美国成为在这一领域做出贡献的主要国家,哥本哈根大学是最著名的大学。出版物和引文最多的作者是ThomasJ.Jentsch。在引用的参考文献中,Voss等人的文章。发表在《科学》(2014年)上的LRRC8异聚体作为体积调节阴离子通道VRAC的关键成分的鉴定获得了极大的关注。PflügersArchiv欧洲生理学杂志和伦敦生理学杂志是相关文章和引文数量方面的领先期刊。通过对关键词共现的分析,发现VRAC参与各种生理过程,包括细胞生长,迁移,凋亡,肿胀,和肌肉发生,以及阴离子和有机渗透物运输,包括氯化物,牛磺酸,谷氨酸和ATP。VRAC也与相关离子通道相关,如TMEM16A,TMEM16F,Pannexin,CFTR,并与包括癫痫在内的各种疾病相关,脑白质营养不良,动脉粥样硬化,高血压,脑水肿,中风,和不同类型的癌症,包括胃癌,胶质母细胞瘤和肝细胞癌。此外,VRAC通过调节铂类药物和替莫唑胺的摄取参与抗肿瘤药物的耐药性。此外,已经在涉及DCPIB和类黄酮的药理学背景下研究了VRAC。结论:本文献计量分析的目的是为VRAC的研究提供一个整体的视角。VRAC已经成为一个越来越感兴趣的话题,我们的分析表明,它仍然是一个突出的领域。这项研究提供了对VRAC通道调查的见解,并可能指导研究人员确定未来研究的新方向。
Objective: In this study, we utilized bibliometric methods to assess the worldwide scientific output and identify hotspots related to the research on the volume-regulated anion channel (VRAC) from 2014 to 2022. Methods: From Web of Science, we obtained studies related to VRAC published from 2014 to 2022. To analyzed the data, we utilized VOSviewer, a tool for visualizing network, to create networks based on the collaboration between countries, institutions, and authors. Additionally, we performed an analysis of journal co-citation, document citation, and co-occurrence of keywords. Furthermore, we employed CiteSpace (6.1. R6 Advanced) to analyzed keywords and co-cited references with the strongest burst. Results: The final analysis included a total of 278 related articles and reviews, covering the period from 2014 to 2022. The United States emerged as the leading country contributing to this field, while the University of Copenhagen stood out as the most prominent institution. The author with most publications and most citations was Thomas J. Jentsch. Among the cited references, the article by Voss et al. published in Science (2014) gained significant attention for its identification of LRRC8 heteromers as a crucial component of the volume-regulated anion channel VRAC. Pflügers Archiv European Journal of Physiology and Journal of Physiology-London were the leading journals in terms of the quantity of associated articles and citations. Through the analysis of keyword co-occurrence, it was discovered that VRAC is involved in various physiological processes including cell growth, migration, apoptosis, swelling, and myogenesis, as well as anion and organic osmolyte transport including chloride, taurine, glutamate and ATP. VRAC is also associated with related ion channels such as TMEM16A, TMEM16F, pannexin, and CFTR, and associated with various diseases including epilepsy, leukodystrophy, atherosclerosis, hypertension, cerebral edema, stroke, and different types of cancer including gastric cancer, glioblastoma and hepatocellular carcinoma. Furthermore, VRAC is involved in anti-tumor drug resistance by regulating the uptake of platinum-based drugs and temozolomide. Additionally, VRAC has been studied in the context of pharmacology involving DCPIB and flavonoids. Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.