背景:双酚A(BPA)暴露与儿童神经发育不良有关,但很少有人知道BPA替代品暴露是否也与儿童神经发育有关。
目的:探讨BPA及其代用品与婴儿12个月时神经发育的关系。
方法:从山东莱州湾(湾)出生队列中纳入了420名12个月的婴儿,中国。BPA及其替代品包括双酚S(BPS)的尿液浓度,双酚B(BPB),双酚AF(BPAF),双酚AP(BPAP),测定双酚P(BPP)和双酚Z(BPZ)。基于Gesell发育时间表(GDS)的发育商(DQ)得分用于评估婴儿神经发育。应用多变量线性回归和加权分位数和(WQS)回归来估计暴露于单个双酚及其混合物与DQ评分的关联。分别。还进行了性别分层分析。
结果:在大多数婴儿中检测到BPA(89.05%),并且在所有双酚中具有最高的中值浓度(0.709ng/mL)。除BPZ外,BPA替代品在婴儿尿样中普遍存在(>70%),和BPS显示最高的中值浓度(0.064ng/mL),其次是BPAP(0.036ng/mL),BPAF(0.028ng/mL),BPP(0.015ng/mL)和BPB(0.013ng/mL)。在多元线性回归中,在所有婴儿中,只有BPAF暴露与社交DQ评分呈负相关(β=-0.334;95%CI:0.650,-0.019).性别分层后,这种负相关在女孩中是显著的(β=-0.605;95%CI:1.030,-0.180)。此外,男童BPA暴露与粗大运动DQ评分呈负相关(β=-1.061;95%CI:2.078,-0.045)。WQS分析证实了这些结果。
结论:我们的研究表明,婴儿期的双酚暴露可能与婴儿神经发育不良有关,BPAF作为一种常用的BPA替代品,对这种不良关联贡献最大,值得更多关注。
BACKGROUND: Bisphenol A (BPA) exposure has been linked to adverse childhood neurodevelopment, but little is known about whether BPA
substitutes exposures are also related to childhood neurodevelopment.
OBJECTIVE: To investigate the associations of exposure to BPA and its
substitutes with infant neurodevelopment at 12 months.
METHODS: A total of 420 infants at 12 months were included from the Laizhou Wan (Bay) Birth Cohort in Shandong, China. Urinary concentrations of BPA and its
substitutes including bisphenol S (BPS), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP) and bisphenol Z (BPZ) were measured. Developmental quotient (DQ) scores based on the Gesell Development Schedules (GDS) were used to evaluate infant neurodevelopment. The multivariable linear regression and weighted quantile sum (WQS) regression were applied to estimate the associations of exposure to individual bisphenols and their mixtures with DQ scores, respectively. Sex-stratified analyses were also performed.
RESULTS: BPA was detected in most infants (89.05%) and had the highest median concentration (0.709 ng/mL) among all bisphenols. BPA
substitutes except BPZ were ubiquitous in infants\' urine samples (>70%), and BPS showed the highest median concentration (0.064 ng/mL) followed by BPAP (0.036 ng/mL), BPAF (0.028 ng/mL), BPP (0.015 ng/mL) and BPB (0.013 ng/mL). In multivariable linear regression, only BPAF exposure was inversely associated with social DQ scores among all infants (β = -0.334; 95% CI: -0.650, -0.019). After sex stratification, this inverse association was significant in girls (β = -0.605; 95% CI: -1.030, -0.180). Besides, BPA exposure was negatively related to gross motor DQ scores in boys (β = -1.061; 95% CI: -2.078, -0.045). WQS analyses confirmed these results.
CONCLUSIONS: Our study suggests that bisphenol exposure during infancy may be associated with poor infant neurodevelopment, and BPAF as a commonly used BPA substitute contributing the most to this adverse association deserves more attention.