■大气中的污染物与女性不良的妊娠结局有关。然而,这种调查在中国北方大都市很少。空气污染影响孕妇的主要暴露窗口也未知。
■对于分析,这项回顾性队列研究纳入了2018年1月至2019年12月在铜川市人民医院记录的6960名孕妇.从最近的监测站到孕妇的污染物浓度值用于估算每个暴露窗口的暴露剂量。建立Logistic回归模型,以研究污染物与自然流产之间的关系,同时控制混杂因素。
■PM2.5是T3(末次月经期[LMP]第一天前30-60天)自然流产的危险因素,(OR:1.305,95%CI:1.143-1.490)和T4(LMP第一天前60-90天),控制协变量后(OR:1.450,95%CI:1.239-1.696)。在同一个窗口,PM10是一个危险因素(OR:1.308,95%CI:1.140-1.500),(OR:1.386,95%CI:1.184-1.621)。在T2(LMP第一天前30天),T3和T4,SO2是自然流产的危险因素(OR:1.185,95%CI:1.025-1.371),(OR:1.219,95%CI:1.071-1.396),(OR:1.202,95%CI:1.040-1.389)。在T3和T4中,NO2是危险因素(OR:1.171,95%CI:1.019-1.346),(OR:1.443,95%CI:1.259-1.655)。在T1(从LMP的第一天到堕胎之日),O3是一个危险因素(OR:1.366,95%CI:1.226-1.521)。
■怀孕前和怀孕期间暴露于高水平的空气污染物可能是孕妇自然流产的危险因素。这项研究进一步说明了减少空气污染排放的重要性。
UNASSIGNED: Pollutants in the atmosphere have been linked to poor pregnancy outcomes in women. However, such investigations are scarce in metropolitan northern China. The major exposure window of air pollution affecting pregnant women is also unknown.
UNASSIGNED: For the analysis, this retrospective cohort study enrolled 6960 pregnant women recorded at Tongchuan People\'s Hospital from January 2018 to December 2019. Pollutant concentration values from the nearest monitoring station to the pregnant women were used to estimate exposure doses for each exposure window. Logistic regression models were created to investigate the connection between pollutants and spontaneous abortion while controlling for confounding factors.
UNASSIGNED: PM2.5 was a risk factor for spontaneous abortion in T3 (30-60 days before the first day of the last menstrual period [LMP]), (OR: 1.305, 95% CI: 1.143-1.490) and T4 (60-90 days before the first day of the LMP),(OR: 1.450, 95% CI: 1.239-1.696) after controlling for covariates. In the same window, PM10 was a risk factor (OR: 1.308, 95% CI: 1.140-1.500), (OR: 1.386, 95% CI: 1.184-1.621). In T2 (30 days before the first day of the LMP), T3, and T4,
SO2 was a risk factor for spontaneous abortion (OR: 1.185, 95% CI: 1.025-1.371), (OR: 1.219, 95% CI: 1.071-1.396), (OR: 1.202, 95% CI: 1.040-1.389). In T3 and T4, NO2 was a risk factor (OR: 1.171, 95% CI: 1.019- 1.346), (OR: 1.443, 95% CI: 1.259-1.655). In T1 (from the first day of the LMP to the date of abortion), O3 was found to be a risk factor (OR: 1.366, 95% CI: 1.226-1.521).
UNASSIGNED: Exposure to high levels of air pollutants before and during pregnancy may be a risk factor for spontaneous abortion in pregnant women. This study further illustrates the importance of reducing air pollution emissions.