背景:坚持抗逆转录病毒治疗对于实现联合国艾滋病规划署2020-2030年快速通道倡议目标的第三个目标至关重要。可靠,有效和准确的依从性测量对于正确评估依从性和预测ART疗效非常重要.简化药物依从性问卷是一个六项量表,评估艾滋病毒感染者对其坚持ART的看法。尽管最近广泛使用,在西班牙的原始研究之外,其测量特性尚未被仔细记录。本文的目的是进行内部一致性可靠性,SMAQ的并发有效性和测量不变性测试。
方法:在亚的斯亚贝巴两个城市接受51个服务提供者提供ART服务的HIV阳性妇女,埃塞俄比亚在2011年至2012年期间完成了HIV治疗转诊网络研究中的SMAQ。402和524名育龄女性患者的两个横截面,分别,在基线和随访时随机选择两个子城市并进行访谈.我们使用Cronbach系数α(α)来评估内部一致性可靠性,Pearson乘积矩相关(r)评估并发效度和多组验证性因子分析分析SMAQ的因子结构和测量不变性。
结果:所有参与者均为女性,平均年龄33岁;中位数:34岁;范围18-45岁。Cronbach对SMAQ的六个项目的α分别为T1对照的0.66、0.68、0.75和0.75,T1干预,T2控制,和T2干预组,分别。项1至6的皮尔逊相关系数分别为0.78、0.49、0.52、0.48、0.76和0.80,在T1与T2之间。我们发现了因子载荷的不变性,观察到的项目截距和因子方差,也被称为强测量不变性,当我们比较患者组间和组间的潜在依从性水平时。
结论:我们的结果表明,六项SMAQ量表对该样本具有足够的信度和效度指标,除了在比较组中是不变的。这项研究的结果加强了支持干预主义者和研究人员越来越多地使用SMAQ的证据,汇总并比较各组和各时间段的依从性得分。
BACKGROUND: Adherence to antiretroviral therapy is critical to the achievement of the third target of the UNAIDS Fast-Track Initiative goals of 2020-2030. Reliable, valid and accurate measurement of adherence are important for correct assessment of adherence and in predicting the efficacy of ART. The Simplified Medication Adherence Questionnaire is a six-item scale which assesses the perception of persons living with HIV about their adherence to ART. Despite recent widespread use, its measurement properties have yet to be carefully documented beyond the original study in Spain. The objective of this paper was to conduct internal consistency reliability, concurrent validity and measurement invariance tests for the
SMAQ.
METHODS: HIV-positive women who were receiving ART services from 51 service providers in two sub-cities of Addis Ababa, Ethiopia completed the
SMAQ in a HIV treatment referral network study between 2011 and 2012. Two cross-sections of 402 and 524 female patients of reproductive age, respectively, from the two sub-cities were randomly selected and interviewed at baseline and follow-up. We used Cronbach\'s coefficient alpha (α) to assess internal consistency reliability, Pearson product-moment correlation (r) to assess concurrent validity and multiple-group confirmatory factor analysis to analyze factorial structure and measurement invariance of the SMAQ.
RESULTS: All participants were female with a mean age of 33; median: 34 years; range 18-45 years. Cronbach\'s alphas for the six items of the
SMAQ were 0.66, 0.68, 0.75 and 0.75 for T1 control, T1 intervention, T2 control, and T2 intervention groups, respectively. Pearson correlation coefficients were 0.78, 0.49, 0.52, 0.48, 0.76 and 0.80 for items 1 to 6, respectively, between T1 compared to T2. We found invariance for factor loadings, observed item intercepts and factor variances, also known as strong measurement invariance, when we compared latent adherence levels between and across patient-groups.
CONCLUSIONS: Our results show that the six-item
SMAQ scale has adequate reliability and validity indices for this sample, in addition to being invariant across comparison groups. The findings of this study strengthen the evidence in support of the increasing use of
SMAQ by interventionists and researchers to examine, pool and compare adherence scores across groups and time periods.