SCN5A重叠综合征是在携带相同SCN5A突变的个体中表达结合不同典型SCN5A相关心律失常综合征方面的表型或可变心律失常表型的临床实体。在这里，我们回顾了有关SCN5A重叠综合征的文献以及目前提出的主要机制。其中,包括SCN5A变体之间相互作用的多因素测定，其他遗传多态性，可能环境因素似乎是最合理的假设。
SCN5A overlap syndromes are clinical entities that express a phenotype combining aspects of different canonical SCN5A-related arrhythmia syndromes or a variable arrhythmic phenotype among individuals carrying the same SCN5A mutation. Here we review the literature addressing SCN5A overlap syndromes as well as the principal mechanisms currently proposed. Among others, a multifactorial determination encompassing an interaction between SCN5A variant(s), other genetic polymorphisms, and possibly environmental factors seems the most plausible hypothesis.
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