UNASSIGNED:在美国眼科学会视力智能研究(IRIS)注册表中评估眼睑癌的患病率并评估相关因素。
UNASSIGNED:回顾性IRIS注册数据库研究。
UNASSIGNED:2010年12月1日至2018年12月1日IRIS登记处的所有患者,具有国际疾病分类,第九和第十次修订,眼睑癌代码(基底细胞癌[BCC],鳞状细胞癌[SCC],恶性黑色素瘤[MM],皮脂腺癌/其他特定恶性肿瘤[SBC],原位黑色素瘤[MIS],和未指明的恶性肿瘤[UMN])。
UNASSIGNED:每种眼睑癌症类型的患病率是总体和年龄组估计的,性别,种族,种族,和吸烟状况。使用单变量和多变量逻辑回归模型检查任何眼睑癌(AEC)或每种癌症类型与可能的危险因素之间的关联。
未授权:每种眼睑癌症类型的患病率和相关因素。
未经证实:有82136例眼睑癌患者。AEC的患病率为每10万人口145.1。癌症特异性患病率范围从87.9(BCC)到25.6(UMN),11.1(SCC),5.0(SBC),4.1(MM),和每10万人口0.4(MIS)。AEC和每种癌症类型的患病率随着年龄的增加而增加(所有P<0.0001),以及AEC的患病率,密件抄送,SCC,男性MM较高(P均<0.0001),MIS(P=0.02)。BCC的患病率,SCC,MM,SBC,与任何其他种族的患者相比,白人的AEC最高(所有P<0.0001)。在具有相关危险因素(年龄,性别,种族,种族,和吸烟状况),AEC与年龄较大的人群相关([<20岁参考{ref。}];赔率比[95%置信区间]:20-39年:3.35[1.96-5.72];40-65年:24.21[14.80-39.59];>65年:42.78[26.18-69.90]),男性(女性[ref.];1.40[1.33-1.48]),白种人(与非裔美国人的反向关联[0.12{0.09-0.16}],亚洲人[0.19{0.13-0.26}],其他[0.59{0.40-0.89}]),和种族(非西班牙裔[参考文献];西班牙裔:0.38[0.33-0.45];未知:0.81[0.75-0.88])。主动吸烟(从不吸烟[ref。])与AEC(1.11[1.01-1.21])相关,BCC(1.27[1.23-1.31]),SCC(1.59[1.46-1.73]),和MM(1.26[1.08-1.46])。
UNASSIGNED:本研究使用大型国家临床眼病数据库报告了眼睑癌的总体和癌症特异性患病率。发现吸烟与AEC有关,密件抄送,SCC,MM,这是一个新的观察。眼睑上癌症的流行病学特征对于识别恶性肿瘤风险较高的患者很有价值。分配医疗资源,改善癌症护理。
UNASSIGNED: To estimate the prevalence of eyelid cancers in the American Academy of Ophthalmology Intelligent Research in Sight (IRIS) Registry and evaluate the associated factors.
UNASSIGNED: Retrospective IRIS Registry database study.
UNASSIGNED: All patients in the IRIS Registry between December 1, 2010, and December 1, 2018, with International Classification of Disease, ninth and 10th revisions, codes for eyelid cancers (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], malignant melanoma [MM], sebaceous carcinoma/other specified malignant neoplasm [SBC], melanoma in situ [MIS], and unspecified malignant neoplasm [UMN]).
UNASSIGNED: The prevalence of each eyelid cancer type was estimated overall and by age group, sex, race, ethnicity, and smoking status. The associations between any eyelid cancer (AEC) or each cancer type and possible risk factors were examined using univariate and multivariate logistic regression models.
UNASSIGNED: Prevalence of and associated factors for each eyelid cancer type.
UNASSIGNED: There were 82 136 patients with eyelid cancer identified. The prevalence of AEC was 145.1 per 100 000 population. The cancer-specific prevalence ranged from 87.9 (BCC) to 25.6 (UMN), 11.1 (SCC), 5.0 (SBC), 4.1 (MM), and 0.4 (MIS) per 100 000 population. The prevalence of AEC and each cancer type increased with increasing age (all P < 0.0001), and the prevalence of AEC, BCC, SCC, and MM was higher in males (all P < 0.0001), MIS (P = 0.02). The prevalence of BCC, SCC, MM, SBC, and AEC was highest in Whites versus that in patients of any other race (all P < 0.0001). In the multivariate logistic regression model with associated risk factors (age, sex, race, ethnicity, and smoking status), AEC was associated with older age groups ([< 20 years reference {ref.}]; odds ratio [95% confidence interval]: 20-39 years: 3.35 [1.96-5.72]; 40-65 years: 24.21 [14.80-39.59]; and > 65 years: 42.78 [26.18-69.90]), male sex (female [ref.]; 1.40 [1.33-1.48]), White race (inverse associations with African Americans [0.12 {0.09-0.16}], Asians [0.19 {0.13-0.26}], others [0.59 {0.40-0.89}]), and ethnicity (non-Hispanic [ref.]; Hispanic: 0.38 [0.33-0.45]; unknown: 0.81 [0.75-0.88]). Active smoking (never smoker [ref.]) was associated with AEC (1.11 [1.01-1.21]), BCC (1.27 [1.23-1.31]), SCC (1.59 [1.46-1.73]), and MM (1.26 [1.08-1.46]).
UNASSIGNED: This study reports the overall and cancer-specific prevalence of eyelid cancers using a large national clinical eye disease database. Smoking was found to be associated with AEC, BCC, SCC, and MM, which is a new observation. This epidemiologic profile of on-eyelid cancers is valuable for identifying patients at a higher risk of malignancy, allocating medical resources, and improving cancer care.