Ruptured abdominal aortic aneurysm

腹主动脉瘤破裂
  • 文章类型: Journal Article
    破裂的腹主动脉瘤(rAAAs)危及生命,需要紧急手术治疗。血管内主动脉破裂修复术(rEVAR)由于其微创方法具有较低的发病率和死亡率,已成为主要策略。尤其是出现血流动力学不稳定和相关合并症的患者。在rEVAR之后,术中血管造影或早期介入后计算机断层扫描血管造影必须排除需要立即再介入的早期1型或3型内漏.rEVAR后持续的2型内漏(T2ELs),与选修案件相比,由于通过剩余的主动脉瘤破裂部位持续的血管外失血,可能导致致命的情况。因此,在rEVAR后的急性术后设置中,必须早期识别与持续出血和血流动力学不稳定相关的持续性T2ELs,并立即进行治疗.rEVAR后T2EL遮挡的不同技术和概念可用,大多数也用于选择性EVAR后的相关T2EL。除了针对持续性T2EL的各种介入栓塞手术外,一些患者需要开放手术阻断T2EL供血动脉,rEVAR后动脉瘤破裂部位的腹腔减压或直接手术补片闭塞。到目前为止,在rAAAs的严峻形势下,尚未确定rEVAR期间先发制人或术中T2EL栓塞的指征.从长远来看,rEVAR后持续的T2ELs可导致动脉瘤持续扩张,并可能出现继发性近端I型内漏,再破裂的风险增加,需要定期随访和早期考虑再干预.迄今为止,只有极少数研究对rEVAR后的T2ELs进行了调查,或将结果与选择性EVAR中的T2ELs持续性的特殊方面进行了比较.这篇叙述性综述旨在介绍目前关于发病率的知识,自然史,rEVAR后T2EL管理的相关性和策略。
    Ruptured abdominal aortic aneurysms (rAAAs) are life-threatening and require emergent surgical therapy. Endovascular aortic repair for rupture (rEVAR) has become the leading strategy due to its minimal invasive approach with expected lower morbidity and mortality, especially in patients presenting with hemodynamic instability and relevant comorbidities. Following rEVAR, intraoperative angiography or early postinterventional computed tomography angiography have to exclude early type 1 or 3 endoleaks requiring immediate reintervention. Persistent type 2 endoleaks (T2ELs) after rEVAR, in contrast to elective cases, can cause possibly lethal situations due to continuing extravascular blood loss through the remaining aortic aneurysm rupture site. Therefore, early identification of relevant persistent T2ELs associated with continuous bleeding and hemodynamic instability and immediate management is mandatory in the acute postoperative setting following rEVAR. Different techniques and concepts for the occlusion of T2ELs after rEVAR are available, and most of them are also used for relevant T2ELs after elective EVAR. In addition to various interventional embolization procedures for persistent T2ELs, some patients require open surgical occlusion of T2EL-feeding arteries, abdominal compartment decompression or direct surgical patch occlusion of the aneurysm rupture site after rEVAR. So far, in the acute situation of rAAAs, indications for preemptive or intraoperative T2EL embolization during rEVAR have not been established. In the long term, persistent T2ELs after rEVAR can lead to continuous aneurysm expansion with the possible development of secondary proximal type I endoleaks and an increased risk of re-rupture requiring regular follow-up and early consideration for reintervention. To date, only very few studies have investigated T2ELs after rEVAR or compared outcomes with those from elective EVAR regarding the special aspects of persisting T2ELs. This narrative review is intended to present the current knowledge on the incidence, natural history, relevance and strategies for T2EL management after rEVAR.
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  • 文章类型: Journal Article
    背景:以前的研究报告说,少数种族/族裔患者比同组患者更常出现破裂的腹主动脉瘤(rAAA)。rAAA治疗方式的分布,无论是开放性动脉瘤修复术(OAR)还是血管内动脉瘤修复术(EVAR),按种族/民族分类仍然不确定。这项研究旨在调查差异,以种族/民族分类为代表,中位数收入,和保险状况,在全国队列中管理rAAA。
    方法:我们使用国家住院患者样本对2002年至2020年接受OAR或EVAR治疗的rAAA患者进行了回顾性分析,按种族/民族组比较修复类型。多级混合效应逻辑回归模型,根据患者和系统水平的因素进行调整,用于根据种族/民族分类计算OAR或EVAR使用的差异。
    结果:我们确定了10,788名rAAA维修人员,其中9,506(88.1%)是白人,605人(5.6%)为黑人,424(3.9%)是西班牙裔,和253(2.4%)是亚裔/美洲原住民。与EVAR相比,亚洲人/美洲原住民的OAR频率最高,(61.7%对38.3%)。在调整后的模型中,OAR与OAR的使用没有统计学上的显著差异按种族/民族分类的EVAR。总的来说,主要支付者和中位数收入也不是AAA治疗方式的统计学显著预测因子.
    结论:我们的研究没有发现种族差异的统计证据,保险,以及管理RAAA的OAR或EVAR的中位数收入和利用率。
    BACKGROUND: Previous studies report that patients of racial/ethnic minorities more frequently present with ruptured abdominal aortic aneurysms (rAAAs) than their counterparts. The distribution of rAAA treatment modality, whether open aneurysm repair (OAR) or endovascular aneurysm repair (EVAR), by race/ethnicity classification remains uncertain. This study aims to investigate disparities, as represented by race/ethnic classification, median income, and insurance status, in the management of rAAA in a national cohort.
    METHODS: We conducted a retrospective analysis of patients admitted with rAAA managed with either OAR or EVAR from 2002 to 2020 using the National Inpatient Sample, comparing repair type by race/ethnicity group. Multilevel mixed effects logistic regression models, adjusted for patient- and system-level factors, were used to calculate difference in use of OAR or EVAR dependent on race/ethnicity classification.
    RESULTS: We identified 10,788 admissions for rAAA repairs, of which 9506 (88.1%) were White, 605 (5.6%) were Black, 424 (3.9%) were Hispanic, and 253 (2.4%) were Asian/Native American. Asians/Native Americans underwent the highest frequency of OAR as compared with EVAR (61.7% vs 38.3%). In the adjusted model, there was no statistically significant difference in the use of OAR vs EVAR by race/ethnicity classification. In total, primary payer and median income were also not statistically significant predictors of AAA treatment modality.
    CONCLUSIONS: Our study found no statistical evidence of disparities with respect to race, insurance, or median income and use of OAR or EVAR for the management of rAAA.
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  • 文章类型: Journal Article
    目的:确定在腹主动脉瘤破裂的开放手术修复中,与开放主动脉交叉钳夹相比,血管内主动脉球囊对照的30天死亡率。
    方法:对2001年至2018年在单一三级护理中心接受肾下rAAA开放性手术修复的所有成年患者进行了回顾性队列研究。174名患者被确认,其中21例患者接受了腔内主动脉球囊控制,137例患者接受了开放式主动脉交叉钳夹。主要结果是30天死亡率。对术前血压和年龄进行双变量多因素logistic回归分析。
    结果:血管内主动脉球囊控制与较低死亡率无显著相关(校正OR=0.75[95CI0.24-2.38],p=0.63),并且当置于局部麻醉下时显示出死亡率改善的趋势(校正OR=0.34[95CI0.06-1.77],p=0.19)。全身麻醉下放置球囊与死亡率下降无显著相关(校正后OR=2.50[95CI0.35-9.13],p=0.46)。
    结论:在接受开放手术修复的rAAA患者中,使用血管内主动脉球囊控制的死亡率没有显着差异,并且可以考虑在适当选择的患者中作为开放式主动脉阻断的替代方法。
    BACKGROUND: To determine 30-day mortality of endovascular aortic balloon control compared with open aortic cross clamp in open surgical repair (OSR) of ruptured abdominal aortic aneurysms (rAAAs).
    METHODS: A retrospective cohort review was performed of all adult patients who underwent OSR of an infrarenal rAAA between 2001 and 2018 at a single tertiary care center. A total of 174 patients were identified, of which 21 patients received endovascular aortic balloon control and 137 patients received an open aortic cross clamp. Primary outcome was 30-day mortality. Two-variable multivariate logistic regression was adjusted for preoperative blood pressure and age.
    RESULTS: Endovascular aortic balloon control was nonsignificantly associated with lower mortality (adjusted odds ratio [OR] = 0.75 (95% confidence interval [CI] 0.24 to 2.38), P = 0.63), and when placed under local anesthesia showed a trend toward improved mortality (adjusted OR = 0.34 (95%CI 0.06 to 1.77), P = 0.19). Balloon placement under general anesthesia was nonsignificantly associated with worse mortality (adjusted OR = 2.50 (95%CI 0.35 to 9.13), P = 0.46).
    CONCLUSIONS: There is no significant difference in mortality with the use of endovascular aortic balloon control in rAAA patients undergoing OSR, and it may be considered as an alternative approach to open aortic cross clamp in properly selected patients.
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  • 文章类型: Journal Article
    背景:腹主动脉瘤破裂(rAAAs)是一种严重的疾病,可导致高死亡率;因此,他们的早期预测可以挽救病人的生命。这项研究的目的是比较各种模型预测rAAA死亡率的准确性,包括格拉斯哥动脉瘤评分(GAS)。温哥华评分系统(VSS),荷兰动脉瘤评分(DAS),爱丁堡破裂动脉瘤评分(ERAS),Hardman指数基于我们机构的rAAA治疗结果。
    方法:在2016年至2022年之间,我们回顾性分析了在我们机构接受rAAA急诊手术的患者的早期结局数据,包括30天死亡率。进行受试者工作特征(ROC)曲线分析以使用ROC曲线下面积(AUC)比较死亡率的动脉瘤评分系统。
    结果:ERAS的AUC更好(0.718;95%置信区间[CI],0.601-0.817)比其他评分系统。在ERAS和Hardman指数之间观察到显着差异(差异:0.179;p=0.016)。GAS之间没有发现显着差异,VSS,和DAS预测风险模型。
    结论:在预测rAAA患者死亡率的模型中,ERAS模型显示出最高的AUC值;然而,仅在ERAS和Hardman指数之间观察到显著差异.这项研究可能有助于制定改善rAAA预测的策略。
    BACKGROUND: Ruptured abdominal aortic aneurysms (rAAAs) are a serious disease that can lead to high mortality; thus, their early prediction can save patients\' lives. The aim of this study was to compare the accuracies of various models for predicting rAAA mortality-including the Glasgow Aneurysm Score, Vancouver Scoring System, Dutch Aneurysm Score, Edinburgh Ruptured Aneurysm Score (ERAS), and Hardman index-based on rAAA treatment outcomes at our institution.
    METHODS: Between 2016 and 2022, we retrospectively analyzed the early outcome data-including 30-day mortality-of patients who underwent emergency surgery for rAAA at our institution. Receiver operating characteristic curve analysis was performed to compare the aneurysm scoring systems for mortality using the area under the receiver operating characteristic curve (AUC).
    RESULTS: The AUC was better for the ERAS (0.718; 95% confidence interval, 0.601-0.817) than for the other scoring systems. Significant differences were observed between ERAS and Hardman indices (difference: 0.179; P = 0.016). No significant differences were found among the Glasgow Aneurysm Score, Vancouver Scoring System, and Dutch Aneurysm Score predictive risk models.
    CONCLUSIONS: Among the models for predicting mortality in patients with rAAA, the ERAS model demonstrated the highest AUC value; however, significant differences were only observed between ERAS and Hardman indices. This study may help develop strategies for improving rAAA prediction.
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  • 文章类型: Journal Article
    背景:观察性研究表明,对于破裂的腹主动脉瘤(rAAA),与开放动脉瘤修复术(OAR)相比,血管内治疗(EVAR)后死亡率降低。我们试图确定rAAA的修复类型和住院死亡率的国家趋势。
    方法:我们在国家住院患者样本中分析了2002年至2020年采用OAR或EVAR治疗的rAAA患者,并评估了按修复类型划分的数量和住院死亡率的年度趋势。多水平混合效应逻辑回归模型适用于患者和系统水平的风险调整。我们评估了时间之间的相互作用,性别,和Elixhauser索引与修复类型。
    结果:我们检查了13,376例rAAA患者。8,357(62.5%)接受了OAR。接受EVAR的患者年龄稍大(73.7vs72.5岁;p<0.001),平均Elixhauser指数略高(4.0vs3.8;p<0.001)。未调整的住院死亡率为37.4%。OAR和EVAR分别为22.4%。EVAR提供了风险调整后的生存优势(OR:0.39,95%CI:0.32,0.46)。EVAR组住院死亡率随着时间的推移有统计学意义的显著降低(交互作用OR=0.96,95%CI:0.95,0.98)。Elixhauser指数与修复的交互作用无统计学意义(交互作用OR:0.95,95%CI:0.87,1.05)。
    结论:OAR和EVAR的生存率随着时间的推移而提高。在过去的二十年中,EVAR在rAAA患者中持续提供了超过OAR的实质性生存优势。
    OBJECTIVE: Observational studies demonstrate reduced mortality after endovascular (EVAR) compared with open aneurysm repair (OAR) for ruptured abdominal aortic aneurysms (rAAAs). We sought to determine national trends in repair type and in-hospital mortality rates for rAAAs.
    METHODS: We analyzed patients with rAAAs managed with OAR or EVAR from 2002 to 2020 in the National Inpatient Sample and evaluated annual trends in volume and in-hospital mortality by repair type. Multilevel mixed effects logistic regression model was fit for patient and system-level risk adjustment. We assessed interactions between time, sex, and Elixhauser index with repair type.
    RESULTS: We examined 13,376 patients with rAAAs. Of these, 8357 (62.5%) underwent OAR. Patients receiving EVAR were slightly older (73.7 vs 72.5 years; P < .001) with slightly higher mean Elixhauser index (4.0 vs 3.8; P < .001). Unadjusted in-hospital mortality was 37.4% vs 22.4% for OAR and EVAR, respectively. EVAR offered a risk-adjusted survival advantage (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.32-0.46). There was a statistically significant reduction of in-hospital mortality over time in the EVAR group (interaction OR, 0.96; 95% CI, 0.95-0.98). The interaction between Elixhauser index and repair was not statistically significant (interaction OR, 0.95; 95% CI, 0.87-1.05).
    CONCLUSIONS: Survival rates for OAR and EVAR improved over time. EVAR persistently provided a substantial survival advantage over OAR in patients with rAAAs over the past 2 decades.
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  • 文章类型: Journal Article
    目的:尽管医学领域取得了重大进展,腹主动脉瘤破裂(rAAAs)患者的生存率几乎没有改善。我们实施了由五种策略组成的协议,以管理接受开放修复手术的rAAA患者。
    方法:该方案包括以下策略:故意低血压<70mmHg,先肺后肾政策(限制性液体复苏和允许少尿症),术后立即拔管,自由饮水,积极行走,并进行常规的二次手术,打开腹部。该研究包括13名患者(11名男性),平均年龄75.5±7.4(范围:58-87)岁,从2016年至2018年接受了该手术,平均随访时间为40.1±9.04个月。观察到五个恶化为血液动力学休克和意识下降,需要在手术前进行插管和通气。其中两名患者需要术前心肺复苏(CPR)。
    结果:所有患者术后恢复意识,包括两名需要心肺复苏的患者。术后立即拔管9例,但其中2例(22.2%)因通气/灌注不匹配而需要重新插管.4例患者接受了连续性肾脏替代治疗,其中三人在手术后48小时内出现无尿。其中两名患者完全康复。每日活动进行平均4.77±3.5(范围1-13)天,腹部开放,在此期间未报告重大事件.在二次手术中发现4例结肠缺血/坏死,两名患者需要Hartman手术,另外两名患者接受左结肠部分切除术。有2例住院死亡率(15.4%)。
    结论:基于协议的方法,通过多学科团队共识和制定最佳手术策略,可以改善接受rAAA急诊手术的患者的临床结局。需要更大样本量的进一步研究来完善方案。
    OBJECTIVE: Although the medical field has made significant progress, there has been little improvement in the survival rate of patients with ruptured abdominal aortic aneurysms (rAAAs). We implemented a protocol consisting of five strategies in the management of rAAA patients who underwent open repair surgery.
    METHODS: The protocol comprised the following strategies: intentional hypotension <70 mmHg, lung first and kidney last policy (restricted fluid resuscitation and permissive oligoanuria), immediate postoperative extubation, free-water intake with active ambulation, and open abdomen with the routine second-look operation. The study included 13 patients (11 male) with a mean age of 75.5 ± 7.4 (range: 58-87) years who underwent the procedure from 2016 to 2018, with a mean follow-up of 40.1 ± 9.04 months. Five deteriorating to hemodynamic shock and decreased consciousness requiring intubation and ventilation prior to surgery were observed. Two of these patients required preoperative cardiopulmonary resuscitation (CPR).
    RESULTS: All patients regained consciousness after surgery, including the two patients who required cardiopulmonary resuscitation. Immediate postoperative extubation was performed in nine patients, but two (22.2%) of them needed re-intubation due to ventilation/perfusion mismatch. Four patients underwent continuous renal replacement therapy, with three of them having anuria for up to 48 h after surgery. Two of these patients made a full recovery. Daily ambulation was carried out for a mean of 4.77 ± 3.5 (range 1-13) days with an open abdomen, during which no significant events were reported. Four cases of colon ischemia/necrosis were identified in the second-look operation, with two patients requiring Hartman\'s procedure and the other two undergoing left colon partial resection. There were two in-hospital mortalities (15.4%).
    CONCLUSIONS: A protocol-based approach, through multidisciplinary team consensus and the development of optimal surgical strategies, could improve clinical outcomes for patients undergoing emergency surgery for rAAA. Further studies with larger sample sizes are needed to refine the protocols.
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  • 文章类型: Case Reports
    背景:牛皮癣,慢性炎症性皮肤病,影响4%的人口,并与各种合并症有关,让它成为公众健康问题。
    方法:我们讨论了一例50岁的重度红皮病型银屑病患者,表现为破裂的囊状腹主动脉瘤(AAA),需要紧急手术和良好的术后随访。阐明牛皮癣和心血管并发症之间的联系。
    结论:银屑病的严重程度与心血管风险相关,并与主动脉瘤有共同的发展途径,如全身性和主动脉炎,动脉僵硬度,强调管理皮肤症状和全身炎症以减少血管合并症的重要性。银屑病患者患AAA的风险较高,保证考虑AAA筛查。关于银屑病患者的皮质类固醇治疗和AAA手术干预的选择存在争议。
    结论:银屑病患者患AAA的风险增加,强调需要警惕的筛查和全面管理。进一步的研究对于理解银屑病和动脉疾病之间的病理生理联系至关重要。指导这些高危患者的预防策略和最佳药物治疗。
    BACKGROUND: Psoriasis, a chronic inflammatory skin condition, affects 4 % of the population and is associated with various comorbidities, making it a public health concern.
    METHODS: We discuss the case of a 50-year-old man with severe erythrodermic psoriasis who presented with a ruptured saccular abdominal aortic aneurysm (AAA), requiring emergency surgery with good postoperative follow-up. shedding light on the link between psoriasis and cardiovascular complications.
    CONCLUSIONS: Psoriasis severity correlates with cardiovascular risk and shares common development pathways with aortic aneurysms such as systemic and aortic inflammation, and arterial stiffness, emphasizing the importance of managing both skin symptoms and systemic inflammation to reduce vascular comorbidities. Psoriasis patients have a higher risk of AAA, warranting consideration for AAA screening. Controversies exist regarding corticosteroid therapy and choice of surgical intervention for AAA in psoriatic patients.
    CONCLUSIONS: Psoriasis patients face an increased risk of AAA, highlighting the need for vigilant screening and comprehensive management. Further research is essential to understanding the pathophysiological connections between psoriasis and arterial diseases, guiding preventive strategies and optimal medical treatments for these high-risk patients.
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  • 文章类型: Journal Article
    目的:开腹治疗(OAT)通常用于预防或治疗破裂腹主动脉瘤(rAAAs)患者的腹腔室综合征(ACS)。本研究旨在评估发病率,治疗,以及2006年至2021年rAAA后OAT的结果。调查复苏液的数据,体重增加,和累积液体平衡可以提供更系统的方法来确定安全的腹部闭合时间。
    方法:这是一项单中心观察性队列研究。该研究包括2006年10月至2021年12月接受rAAA和OAT治疗的所有患者。
    结果:244例接受rAAA手术的患者中有72例接受了OAT。平均年龄72±7.85岁,大多数是男性(n=61,85%)。最常见的合并症是心脏病(n=31,43%)和高血压(n=31,43%)。52例患者(72%)接受预防性OAT,20人接受了ACS的OAT(28%)。预防性OAT组的死亡率为25%,而接受OAT治疗的ACS患者的死亡率为50%(p=.042)。存活至关闭的58例(81%)患者的OAT中位天数为12天(四分位距[IQR]9,16.5天),换药天数为5天(IQR4,7)。共有1例皮肤瘘和2例移植物感染。所有58例患者均成功进行了腹部闭合,55(95%)进行延迟初次闭合。医院生存率为85%。随着时间的推移,治疗趋势显示,通过Fisher精确检验评估,预防性OAT的使用增加(p≤.001),ACS病例减少(p=.03)。在多变量回归分析中,液体超负荷和体重减轻可预测闭合时间的变异性为26%。
    结论:rAAA后的预防性OAT可以安全地进行,即使在长期治疗后,延迟的原发性闭合率也很高。
    OBJECTIVE: Open abdomen therapy (OAT) is commonly used to prevent or treat abdominal compartment syndrome (ACS) in patients with ruptured abdominal aortic aneurysms (rAAAs). This study aimed to evaluate the incidence, treatment, and outcomes of OAT after rAAA from 2006 to 2021. Investigating data on resuscitation fluid, weight gain, and cumulative fluid balance could provide a more systematic approach to determining the timing of safe abdominal closure.
    METHODS: This was a single centre observational cohort study. The study included all patients treated for rAAA followed by OAT from October 2006 to December 2021.
    RESULTS: Seventy-two of the 244 patients who underwent surgery for rAAA received OAT. The mean age was 72 ± 7.85 years, and most were male (n = 61, 85%). The most frequent comorbidities were cardiac disease (n = 31, 43%) and hypertension (n = 31, 43%). Fifty-two patients (72%) received prophylactic OAT, and 20 received OAT for ACS (28%). There was a 25% mortality rate in the prophylactic OAT group compared with the 50% mortality in those who received OAT for ACS (p = .042). The 58 (81%) patients who survived until closure had a median of 12 (interquartile range [IQR] 9, 16.5) days of OAT and 5 (IQR 4, 7) dressing changes. There was one case of colocutaneous fistula and two cases of graft infection. All 58 patients underwent successful abdominal closure, with 55 (95%) undergoing delayed primary closure. In hospital survival was 85%. Treatment trends over time showed the increased use of prophylactic OAT (p ≤ .001) and fewer ACS cases (p = .03) assessed by Fisher\'s exact test. In multivariable regression analysis fluid overload and weight reduction predicted 26% of variability in time to closure.
    CONCLUSIONS: Prophylactic OAT after rAAA can be performed safely, with a high rate of delayed primary closure even after long term treatment.
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  • 文章类型: Journal Article
    背景:对于具有解剖学上适当的腹主动脉瘤(AAA)的患者,血管内主动脉修复(EVAR)是一种比生理上更有压力的开放式手术修复(OSR)侵入性更小的方法。术后早期结果与患者的生理储备和手术干预的生理应激有关。在生理储备减少的虚弱患者中,主动脉破裂的应力与手术修复的应力相结合的耐受性较差,增加并发症和死亡率的风险。这项研究旨在评估接受微创EVAR的患者的虚弱与预后之间的相关性差异,以及破裂的AAA(rAAA)的生理压力更大的OSR。
    方法:我们的回顾性队列研究包括2010年至2022年在血管质量倡议中接受rAAA修复的成年人。经过验证的风险分析指数(RAI;稳健≤20,正常21-29,脆弱30-39,非常脆弱≥40)量化了虚弱。使用多变量Cox模型比较了1年死亡率与虚弱状态以及修复类型的主要结局之间的关联,该模型产生了具有95%置信区间(95CI)的校正风险比(aHR)。交互术语评估了关联的审核。
    结果:我们确定了5,806例患者(年龄72±9岁;男性77%;EVAR65%;健壮6%;正常48%;虚弱36%;非常虚弱10%),在rAAA修复后观察到1年死亡率为53%。与EVAR相比,OSR[aHR=1.43(95CI1.19-1.73)]与1年死亡率增加相关。虚弱状态增加[虚弱的aHR=1.26(95CI1.00-1.59);非常虚弱的aHR=1.64(95CI1.26-2.13)]与1年死亡率增加相关。由修复类型调节(P相互作用<0.05)。OSR与正常[aHR=1.49(95CI1.20-1.87)]和虚弱[aHR=1.51(95CI1.20-1.89)]的1年死亡率增加相关,但不在健壮[aHR=0.88(95CI0.59-1.32)]和非常虚弱[aHR=1.29(95CI0.97-1.72)]的患者中。
    结论:脆弱和OSR与rAAA修复后1年死亡率的调整风险增加相关。在正常和虚弱的患者中,与EVAR相比,OSR与1年死亡率的调整风险增加相关。然而,OSR和EVAR在能很好地耐受OSR应激的健壮患者和无论何种修复类型都无法耐受rAAA的手术应激的非常虚弱的患者之间没有差异.
    OBJECTIVE: Endovascular aortic repair (EVAR) is a less invasive method than the more physiologically stressful open surgical repair (OSR) for patients with anatomically appropriate abdominal aortic aneurysms (AAAs). Early postoperative outcomes are associated with both patients; physiologic reserve and the physiologic stresses of the surgical intervention. Among frail patients with reduced physiologic reserve, the stress of an aortic rupture in combination with the stress of an operative repair are less well tolerated, raising the risk of complications and mortality. This study aims to evaluate the difference in association between frailty and outcomes among patients undergoing minimally invasive EVAR and the physiologically more stressful OSR for ruptured AAAs (rAAAs).
    METHODS: Our retrospective cohort study included adults undergoing rAAA repair in the Vascular Quality Initiative from 2010 to 2022. The validated Risk Analysis Index (RAI) (robust, ≤20; normal, 21-29; frail, 30-39; very frail, ≥40) quantified frailty. The association between the primary outcome of 1-year mortality and frailty status as well as repair type were compared using multivariable Cox models generating adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs). Interaction terms evaluated the association\'s moderation.
    RESULTS: We identified 5806 patients (age, 72 ± 9 years; 77% male; EVAR, 65%; robust, 6%; normal, 48%; frail, 36%; very, frail 10%) with a 53% observed 1-year mortality rate following rAAA repair. OSR (aHR, 1.43; 95% CI, 1.19-1.73) was associated with increased 1-year mortality when compared with EVAR. Increasing frailty status (frail aHR, 1.26; 95% CI, 1.00-1.59; very frail aHR, 1.64; 95% CI, 1.26-2.13) was associated with increased 1-year mortality, which was moderated by repair type (P-interaction < .05). OSR was associated with increased 1-year mortality in normal (aHR, 1.49; 95% CI, 1.20-1.87) and frail (aHR, 1.51; 95% CI, 1.20-1.89), but not among robust (aHR, 0.88; 95% CI, 0.59-1.32) and very frail (aHR, 1.29; 95% CI, 0.97-1.72) patients.
    CONCLUSIONS: Frailty and OSR were associated with increased adjusted risk of 1-year mortality following rAAA repair. Among normal and frail patients, OSR was associated with an increased adjusted risk of 1-year mortality when compared with EVAR. However, there was no difference between OSR and EVAR among robust patients who can well tolerate the stress of OSR and among very frail patients who are unable to withstand the surgical stress from rAAA regardless of repair type.
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  • 文章类型: Case Reports
    此病例报告详细介绍了在越南实施的一项新技术。当没有完整的设备时,我们通过使用主动脉球囊闭塞来适应它,以增强患者的血流动力学并减轻术中放血的风险。这种方法有效地解决了血液动力学不稳定患者腹主动脉瘤的破裂。
    This case report details a novel technique implemented in Vietnam. When full equipment is unavailable, we adapt it by using aortic balloon occlusion to enhance the patient\'s hemodynamics and mitigate the risk of intraprocedural exsanguination. This approach effectively addresses the rupture of abdominal aortic aneurysms in patients with unstable hemodynamic conditions.
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