CorneliadeLange(CdLS),脆性X(FXS)和Rubinstein-Taybi综合征(RTS)证明了自闭症特征的独特特征。为了进一步描绘这些轮廓,CdLS儿童早期社会认知能力的发展,将FXS和RTS与在典型发育(TD)和自闭症(AUT)儿童中观察到的比较。
患有CdLS的儿童(N=22),FXS(N=19)和RTS(N=18),完成了早期社会认知量表(ESCogS)。使用来自AUT(N=19)和TD(N=86)儿童的现有数据进行比较。
类似于AUT儿童,患有CdLS的儿童,FXS和RTS在传递ESCogS任务时显示出整体延迟。CdLS患儿表现出与AUT患儿相似的延迟程度,并且比FXS和RTS患儿的延迟更大。CdLS,FXS和RTS组未按照在TD和AUT儿童中观察到的相同顺序通过任务。患有CdLS的儿童(p=0.04),FXS(p=0.02)和RTS(p=0.04)在需要理解他人简单意图的任务上比需要共同注意技能的任务表现更好。
除一般认知延迟外的潜在机制可能会破坏CdLS儿童的早期社交认知发展,FXS和RTS。讨论了可能破坏这些综合征中早期社会认知发展的因素。
Cornelia de Lange (CdLS), Fragile X (FXS) and Rubinstein-Taybi syndromes (RTS) evidence unique profiles of autistic characteristics. To delineate these profiles further, the development of early social cognitive abilities in children with CdLS, FXS and RTS was compared to that observed in typically developing (TD) and autistic (AUT) children.
Children with CdLS (N = 22), FXS (N = 19) and RTS (N = 18), completed the Early Social Cognition Scale (ESCogS). Extant data from AUT (N = 19) and TD (N = 86) children were used for comparison.
Similar to AUT children, children with CdLS, FXS and RTS showed an overall delay in passing ESCogS tasks. Children with CdLS showed a similar degree of delay to AUT children and greater delay than children with FXS and RTS. The CdLS, FXS and RTS groups did not pass tasks in the same sequence observed in TD and AUT children. Children with CdLS (p = 0.04), FXS (p = 0.02) and RTS (p = 0.04) performed better on tasks requiring understanding simple intentions in others significantly more than tasks requiring joint attention skills.
An underlying mechanism other than general cognitive delay may be disrupting early social cognitive development in children with CdLS, FXS and RTS. Factors that may disrupt early social cognitive development within these syndromes are discussed.