■鼻塞,由过敏性鼻炎引发,通常不能单独使用过敏原特异性免疫疗法(AIT)解决,因此可能需要下鼻甲复位手术(ITR)。本研究旨在探讨综合治疗对鼻塞的影响,目前证据有限。
■对经历鼻塞并经历≥12个月AIT的常年性变应性鼻炎患者进行回顾性队列研究。得出两组,那些正在接受AIT的人-有或没有ITR。监测患者报告的鼻塞(用问卷评估)和鼻气道功能(鼻峰值吸气流量[NPIF]和鼻气流阻力[NAR])。比较各组从基线到治疗后12个月的变化。
■总共118名患者(33.71±14.43岁,41.5%女性)被招募,72%有AIT,28%有AIT和ITR。在基线,AIT和ITR组的鼻塞水平较高(>中度%;63.6%vs52.9%,P=.048)。治疗后,AIT和ITR组报告鼻塞减少更大(>1类变化:75.8%vs48.2%,P=.002)。同样,通过NPIF,AIT和ITR组的鼻功能改善更大(-13.9±110.3L/分钟vs-3.4±78.1L/分钟,P=.049)和NAR(-0.120±0.342Pa/cmm3/秒vs-0.093±0.224Pa/cmm3/秒,P=.050)。
■变应性鼻炎患者,中度至重度鼻塞,与单独的AIT相比,接受AIT和ITR联合治疗的患者可以更好地缓解鼻塞并改善气流分析。
UNASSIGNED: Nasal obstruction, triggered by allergic rhinitis, often does not resolve with allergen-specific immunotherapy (AIT) alone, thus inferior turbinate reduction surgery (ITR) may be required. This study aims to investigate the impact of combined treatment on nasal obstruction, as evidence is currently limited.
UNASSIGNED: A retrospective cohort study of perennial allergic rhinitis patients experiencing nasal obstruction and undergoing ≥12 months AIT was conducted. Two groups were derived, those undergoing AIT-with or without an ITR. Patient reported nasal obstruction (evaluated with questionnaires) and nasal airway function (Nasal Peak Inspiratory Flow [NPIF] and Nasal Airflow Resistance [NAR]) were monitored. The change from baseline to 12 months post-treatment in each group were compared.
UNASSIGNED: A total of 118 patients (33.71 ± 14.43 years, 41.5% female) were recruited, 72% had AIT and 28% AIT&ITR. At baseline, the AIT&ITR group had a higher level of nasal obstruction (>moderate%; 63.6% vs 52.9%, P = .048). Post treatment, AIT&ITR group reported greater reduction in nasal obstruction (>1 category change: 75.8% vs 48.2%, P = .002). Similarly, the AIT&ITR group had greater improvement in nasal function by NPIF (-13.9 ± 110.3 L/minute vs -3.4 ± 78.1 L/minute, P = .049) and NAR (-0.120 ± 0.342 Pa/cm³/second vs -0.093 ± 0.224 Pa/cm³/second, P = .050).
UNASSIGNED: Allergic rhinitis patients, with moderate to severe nasal obstruction, who undergo combined AIT&ITR have greater relief of nasal obstruction and improved airflow analysis compared to AIT alone.