ABO血型与某些微生物感染的易感性有关,包括冠状病毒.我们检查了感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的个体的血型与临床结局之间的关系,并将其血型分布与普通人群进行了比较。
大流行开始时,在科威特,所有SARS-CoV-2检测呈阳性的个体均被纳入一家指定的2019年冠状病毒病(COVID-19)医院,并纳入前瞻性登记.2020年2月24日至5月27日收治的患者根据血型进行分层。作为一种控制,代表几乎科威特的整个人口的3,730,027名匿名个体的血型是从国家数据库获得的。
在3305名SARS-CoV-2阳性患者中,37.1%,25.5%,28.9%,8.5%是O组,A,B,AB,分别。单变量分析显示各血型间严重临床结局或死亡无显著差异。然而,多变量分析表明,与非A组相比,A组个体发生肺炎的几率更高(校正比值比1.32,95%置信区间1.02-1.72,p<.036)。与普通人群相比,COVID-19队列中O组的频率较低,A的等效频率,B和AB的频率更高。在RhD组中没有发现显著差异。
这项研究支持ABO血型系统在未选择的人群中可能参与SARS-CoV-2的感染。有必要检查血型与COVID-19之间的机制联系及其对控制当前大流行的意义。
ABO blood groups have been linked to susceptibility to infection with certain microorganisms, including coronaviruses. We examined the relationship between blood group and clinical outcomes in individuals infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and compared their blood group distribution with the general population.
At the inception of the pandemic, all individuals testing positive for SARS-CoV-2 in Kuwait were admitted to one designated coronavirus disease 2019 (COVID-19) hospital and enrolled in a prospective registry. Patients admitted from February 24 to May 27, 2020, were stratified according to blood group. As a control, blood groups of 3,730,027 anonymized individuals representing almost Kuwait\'s entire population were obtained from a national database.
Of 3305 SARS-CoV-2-positive patients, 37.1%, 25.5%, 28.9%, and 8.5% were groups O, A, B, and AB, respectively. Univariate analysis revealed no significant differences in severe clinical outcomes or death among the blood groups. However, multivariable analysis demonstrated that group A individuals had higher odds of developing pneumonia compared with non-group A (adjusted odds ratio 1.32, 95% confidence interval 1.02-1.72, p < .036). Compared with the general population, the COVID-19 cohort had a lower frequency of group O, equivalent frequency of A, and higher frequency of B and AB. No significant difference in the RhD group was found.
This study supports potential involvement of the ABO blood group system in predisposing to infection with SARS-CoV-2 in an unselected population. Examination of the mechanistic link between blood group and COVID-19 and its implications on controlling the current pandemic is warranted.