■我们旨在识别正常眼睛的结构差异,早期年龄相关性黄斑变性(AMD),和中间AMD眼睛使用光学相干断层扫描(OCT)在一个良好的特征,大横截面队列。
■健康眼睛≥60岁的受试者,阿拉巴马州年龄相关性黄斑变性2研究(ALSTAR2;NCT04112667)纳入了早期或中期AMD。使用SpectralisHRA+OCT2,我们获得了每个参与者的黄斑体积。使用自动分割软件分割六个层和子层:感光体内段和外段,视网膜下椎间盘样沉积(SDDs),视网膜色素上皮+基底膜(RPE+BL),玻璃疣,和脉络膜.手动细化所有B扫描的分割后,整体的平均厚度,中央,计算并组间比较ETDRS网格的内环和外环。
■这项研究涉及502名患者,252人健康,147患有早期AMD,103眼患有中度AMD(根据年龄相关性眼病研究[AREDS]9步)。中度AMD眼睛表现出较厚的SDD和玻璃疣,较薄的光感受器内段,和RPE与健康和早期AMD眼睛相比。它们的光感受器外节也比早期AMD眼厚。早期AMD眼睛的光感受器外节比正常眼睛薄,但脉络膜比中间AMD眼睛厚。用贝克曼量表,最初分类为早期AMD的眼睛中有42%转变为中间AMD,使感光体外段和脉络膜的厚度差异不大。
■对于AMD阶段,最一致的结构差异包括玻璃疣和SDD的外观,其次是RPE+BL厚度,然后是感光体内段和外段的厚度。从老化到中间AMD过渡的结构变化包括外视网膜带的改变,包括RPE两侧沉积物的外观。
UNASSIGNED: We aimed to identify structural differences in normal eyes, early age-related macular degeneration (AMD), and intermediate AMD eyes using optical coherence tomography (OCT) in a well-characterized, large cross-sectional cohort.
UNASSIGNED: Subjects ≥ 60 years with healthy normal eyes, as well as early or intermediate AMD were enrolled in the Alabama Study on Age-related Macular Degeneration 2 (ALSTAR2; NCT04112667). Using Spectralis HRA + OCT2, we obtained macular volumes for each participant. An auto-segmentation software was used to segment six layers and sublayers: photoreceptor inner and outer segments, subretinal drusenoid deposits (SDDs), retinal pigment epithelium + basal lamina (RPE + BL), drusen, and choroid. After manually refining the segmentations of all B-scans, mean thicknesses in whole, central, inner and outer rings of the ETDRS grid were calculated and compared among groups.
UNASSIGNED: This study involved 502 patients, 252 were healthy, 147 had early AMD, and 103 had intermediate AMD eyes (per Age-Related Eye Disease Study [AREDS] 9-step). Intermediate AMD eyes exhibited thicker SDD and drusen, thinner photoreceptor inner segments, and RPE compared to healthy and early AMD eyes. They also had thicker photoreceptor outer segments than early AMD eyes. Early AMD eyes had thinner photoreceptor outer segments than normal eyes but a thicker choroid than intermediate AMD eyes. Using the Beckman scale, 42% of the eyes initially classified as early AMD shifted to intermediate AMD, making thickness differences for photoreceptor outer segments and choroid insignificant.
UNASSIGNED: With AMD stages, the most consistent structural differences involve appearance of drusen and SDD, followed by RPE + BL thickness, and then thickness of photoreceptor inner and outer segments. Structural changes in the transition from aging to intermediate AMD include alterations in the outer retinal bands, including the appearance of deposits on either side of the RPE.