这项研究的目的是研究物理化学，结构,和基于羧甲基纤维素（CMC）的冷冻凝胶珠的体外释放特性，其中包含用于结肠靶向递送系统的白藜芦醇负载的微粒（MP）。CMC基冷冻凝胶珠通过不同浓度的离子交联生产（2％，3%,4%)的AlCl3。基于FE-SEM图像，随着AlCl3浓度的增加，CMC基冷冻凝胶珠显示出更光滑的表面和更致密的内部结构，通过FT-IR分析证明这是由于CMC的-COO-基团与Al3之间的新交联。通过将AlCl3的浓度从2％提高到4％，冷冻凝胶珠的包封效率从79.48％显着提高到85.74％，分别。体外释放研究表明，在模拟胃条件下，所有基于CMC的冷冻凝胶珠对白藜芦醇的稳定性均高于MP，并且可以有效地将白藜芦醇递送至结肠而不会过早释放。
The objective of this study was to investigate the physicochemical, structural, and in vitro release properties of carboxymethyl cellulose (CMC)-based cryogel beads incorporating resveratrol-loaded microparticles (MP) for colon-targeted delivery system. CMC-based cryogel beads were produced by ionic cross-linking with different concentrations (2%, 3%, and 4%) of AlCl3. Based on FE-SEM images, CMC-based cryogel beads showed a smoother surface and more compact internal structure with increasing AlCl3 concentrations, which was proven to be due to the new cross-linking between the -COO- group of CMC and Al3+ by FT-IR analysis. The encapsulation efficiency of the cryogel beads was significantly increased from 79.48% to 85.74% by elevating the concentrations of AlCl3 from 2% to 4%, respectively. In vitro release study showed that all CMC-based cryogel beads had higher stability for resveratrol than MP in simulated gastric conditions and can efficiently deliver resveratrol to colon without the premature release.
