■由呼吸道病毒引起的流感样疾病(ILI)导致各种呼吸道临床表现。ILI002前瞻性观察性队列研究旨在描述病毒制剂,季节性,和ILI患者在流感H1N1大流行的四个季节和大流行后的年份(2010-2014)的结局。
■从2010年4月至2014年3月纳入了来自墨西哥六家医院的患者。获得临床数据和鼻咽拭子,并通过实时逆转录聚合酶链反应检测病毒性呼吸道病原体。
■在5662名注册参与者中,64.9%为成人,35.1%为儿童。在单病原体检测的5629名参与者中,鼻病毒(20.2%),流感病毒(11.2%),呼吸道合胞病毒(RSV)(7.2%),冠状病毒(6.8%)是最常见的病原体。14.5%的病例发生合并感染;49.3%的参与者需要住院治疗,特别是在RSV病例中(42.9%的成年人,89.6%儿童)。老年参与者和有合并症者的死亡率高出2.8%。甲型H1N1流感死亡率最高,然而,几乎一半的死者没有病原体。鼻病毒全年持续存在,而流感,冠状病毒,RSV在较冷的月份达到峰值。
分析显示,一些引起ILI的病毒可能导致严重的疾病和住院,而不考虑合并症。这些发现可能有助于制定有关预防措施的公共卫生政策,疫苗接种,治疗,和卫生保健管理。
UNASSIGNED: Influenza-like illness (ILI) caused by respiratory viruses results in various respiratory clinical manifestations. The ILI002 prospective observational cohort study aimed to describe viral agents, seasonality, and outcomes of patients with ILI during four seasons in the influenza H1N1-pandemic and post-pandemic years (2010-2014).
UNASSIGNED: Patients from six Mexican hospitals were enrolled from April 2010 to March 2014. Clinical data and nasopharyngeal swabs were obtained and tested for viral respiratory pathogens by real-time reverse-transcription polymerase chain reaction.
UNASSIGNED: Of the 5662 enrolled participants, 64.9% were adults and 35.1% were children. Among the 5629 participants with single-pathogen detection, rhinovirus (20.2%), influenza virus (11.2%), respiratory syncytial virus (RSV) (7.2%), and coronavirus (6.8%) were the most frequent pathogens. Co-infection occurred in 14.5% of cases; 49.3% of participants required hospitalization, particularly in RSV cases (42.9% adults, 89.6% children). The mortality rate was 2.8% higher among older adult participants and those with comorbidities. Influenza H1N1 had the highest mortality rate, yet almost half of the deceased had no pathogen. Rhinovirus persisted year-round, while influenza, coronavirus, and RSV peaked during cooler months.
UNASSIGNED: Analyses showed that some viruses causing ILI may lead to severe disease and hospitalization irrespective of comorbidities. These findings may help in decision-making about public health policies on prevention measures, vaccination, treatment, and administration of health care.