分析肝细胞癌(HCC)患者经动脉用Yttric-90负载树脂微球进行放射性栓塞(TARE)后血管生成因子的变化。
白细胞介素-6,白细胞介素-8,肝细胞生长因子,血小板源性生长因子,成纤维细胞生长因子,血管内皮生长因子-A(VEGF-A),在TARE前和TARE后第1,7,14和30天测量了26例患者的血管生成素-2水平,并评估了放射学反应.
在随访的第六个月,11例(42.30%)患者对治疗有完全或部分反应,在15例(57.69%)患者中发现了进行性疾病。在TARE后第30天(P=0.034),无反应者中VEGF-A的百分比变化明显更明显。无反应者的VEGF-A峰值形成率较高(P=0.036)。
负载钇-90的树脂微球TARE后,HCC患者血管生成因子的短期变化在不同时间以不同幅度波动。生长因子的上调具有预后能力。TARE后VEGF-A的变化可能有助于早期识别无应答者。
To analyze changes in angiogenesis factors after transarterial radioembolization (TARE) with Yttrium- 90-loaded resin microspheres in hepatocellular carcinoma (HCC) patients.
Interleukin-6, interleukin-8, hepatocyte growth factor, platelet-derived growth factor, fibroblast growth factor, vascular endothelial growth factor-A (VEGF-A), and angiopoietin-2 levels in 26 patients were measured before TARE and on day 1, 7, 14, and 30 after TARE and evaluated regarding radiological response.
In the sixth month of follow-up, 11 (42.30%) patients had a complete or partial response to treatment, while progressive disease was found in 15 (57.69%) patients. The percentage changes in VEGF-A in the non-responders on day 30 (P = 0.034) after TARE were significantly more obvious. Peak formation rates of VEGF-A were higher in non-responders (P = 0.036).
Short-term changes in angiogenesis factors in HCC patients after TARE with Yttrium-90-loaded resin microspheres fluctuate with different amplitudes at different times. The upregulation of growth factors has a prognostic capacity. Changes in VEGF-A after TARE may be helpful for the early recognition of non-responders.