背景:地中海-DASH干预神经退行性延迟(MIND)饮食可能会减缓老年人的认知功能下降。潜在的机制可能是MIND饮食的抗炎特性。
目的:研究基线时坚持MIND饮食是否与轻度认知障碍(MCI)的几率和炎症生物标志物(高敏C反应蛋白(hsCRP)的变化有关,白介素-6(IL-6))在≥70岁的成年人中超过三年。
方法:在基线和三年后,通过食物频率问卷(FFQ)评估对MIND饮食的依从性。根据蒙特利尔认知评估(MoCA),MCI的存在被定义为<26(MCI26),或<24(MCI24)。我们进行了一个控制性别的最小调整模型,之前的秋天,85岁时的线性样条,时间,治疗和研究地点。完全调整后的模式也针对教育进行了调整,BMI,身体活动,抑郁评分,每日能量摄入,和合并症评分。为了评估炎症标志物相对于基线的变化,我们使用线性混合效应模型对相同变量加上各自的基线浓度进行了调整.使用两个MoCA截止值的可靠变化指数,对重复认知测试的实践效果进行了敏感性分析。
结果:我们纳入了2157名DO-HEALTH参与者中的2028名(60.5%为女性;平均年龄74.88岁)的完整数据。在基线时坚持MIND饮食与三年内认知能力下降无关。无论是在MoCA<26(OR(95CI)=0.99(0.94-1.04))还是在MoCA<24(OR(95CI)=1.03(0.96-1.1))。将可靠的变化指数应用于两个截止值证实了这一发现。Further,在DO-HEALTH中,MIND饮食依从性与MoCA评分相对于基线的变化无关.对于炎症生物标志物,MIND饮食基线依从性与hsCRP或IL-6的变化无关。
结论:坚持MIND饮食与MCI的几率无关,也与基线时的hsCRP或IL-6无关。此外,超过3年的MIND饮食变化与hsCRP或IL-6的变化无关.
The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet may slow cognitive decline in older adults. A potential mechanism could be possible anti-inflammatory properties of the MIND-diet.
To examine whether adherence to the MIND diet at baseline is associated with the odds of mild cognitive impairment (MCI) and changes in biomarkers of inflammation (High-sensitivity C-reactive Protein(hsCRP), interleukin-6(IL-6)) over three years in adults ≥70 years.
Adherence to the MIND diet was assessed by food frequency questionnaire (FFQ) at baseline and after three years. Presence of MCI based on the Montreal Cognitive Assessment (MoCA) was defined as <26 (MCI26), or <24 (MCI24). We performed a minimally adjusted model controlling for sex, prior fall, linear spline at age 85, time, treatment and study site. The fully adjusted model also adjusted for education, BMI, physical activity, depression score, daily energy intake, and comorbidity score. To assess the change in inflammatory markers from baseline, we used linear-mixed-effect models adjusted for the same variables plus the respective baseline concentrations. Sensitivity analyses accounting for practice effects of repeated cognitive tests using the reliable change index for both MoCA cut-offs were done.
We included 2028 of 2157 DO-HEALTH participants (60.5% women; mean age 74.88 years) with complete data. Adherence to the MIND diet at baseline was not associated with cognitive decline over three years, neither at MoCA < 26 (OR (95%CI) = 0.99 (0.94-1.04)) nor at MoCA < 24 (OR (95%CI) = 1.03 (0.96-1.1)). Applying the reliable change index to the two cut-offs confirmed the findings. Further, the MIND diet adherence was not associated with the change in MoCA score from baseline in DO-HEALTH. For inflammatory biomarkers MIND-diet baseline adherence was not associated with changes in hsCRP or IL-6.
Adherence to the MIND-diet was neither associated with the odds of MCI, nor with hsCRP or IL-6 at baseline. Moreover, change in MIND-diet over three years was not associated with changes in hsCRP or IL-6.