Reimplantation

再植
  • 文章类型: Case Reports
    患者为28岁男性。他休息时胸痛。他被紧急导管诊断为AAORCA(右冠状动脉的异常主动脉起源)。心肌闪烁显像显示右冠状动脉区域缺血性改变,所以手术是计划。选择再植入,因为冠状动脉计算机断层扫描显示壁内移动少,冠状动脉轻度狭窄。手术是在下小胸骨切开术下进行的,以促进早期恢复工作。患者术后病程良好,术后第11天康复出院。我们报告了一例AAORCA的下胸骨小切开术右冠状动脉再植术。
    The patient was 28-year-old male. He was suffered from chest pain at rest. He was diagnosed with AAORCA (anomalous aortic origin of the right coronary artery) by emergency catheter. Myocardial scintigraphy indicated ischemic changes in the right coronary artery region, so surgery was the plan. Reimplantation was selected because the coronary artery computed tomography showed little intramural travel and mild coronary artery stenosis. The surgery was performed under lower mini-sternotomy to facilitate early return to work. The patient had a good postoperative course, and was discharged from the hospital postoperative Day 11 after rehabilitation. We report a case of the right coronary artery reimplantation with lower mini-sternotomy for AAORCA.
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  • 文章类型: Journal Article
    我们描述了机器人辅助根治性膀胱切除术(RARC)和尿流改道后,机器人辅助修复输尿管-肠狭窄(UES)的技术和结果。
    对我们2005年11月至2023年8月在罗斯威尔公园综合癌症中心的RARC数据库进行了回顾性审查。确定了发生UES并最终接受机器人辅助输尿管肠再植(RUER)的患者。使用Kaplan-Meier方法计算RUER后UES的累积复发率。使用多变量回归模型来识别与UES复发相关的变量。
    在808名RARC患者中,共有123名(15%)出现了UES,其中52例接受了再植术(45例患者接受了RUER[n=55例],7例患者接受了输尿管-肠开放再植术)。从RARC到UES的中位时间为4.4(四分位距3.0-7.0)个月,UES和RUER的中位时间为5.2个月(四分位距3.2-8.9个月).RUER术后3年复发率约为29%。在多变量分析中,住院时间延长(风险比1.37,95%置信区间1.16-1.61,p<0.01)与RUER术后复发性UES相关.
    RUER治疗RARC术后UES是可行的,具有持久的结局,尽管一部分明显的患者出现了术后并发症和UES复发。
    UNASSIGNED: We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures (UES) following robot-assisted radical cystectomy (RARC) and urinary diversion.
    UNASSIGNED: Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was performed. Patients who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation (RUER) were identified. Kaplan-Meier method was used to compute the cumulative incidence recurrence rate of UES after RUER. A multivariable regression model was used to identify variables associated with UES recurrence.
    UNASSIGNED: A total of 123 (15%) out of 808 RARC patients developed UES, of whom 52 underwent reimplantation (45 patients underwent RUER [n=55 cases] and seven patients underwent open uretero-enteric reimplantation). The median time from RARC to UES was 4.4 (interquartile range 3.0-7.0) months, and the median time between UES and RUER was 5.2 (interquartile range 3.2-8.9) months. The 3-year recurrence rate after RUER is about 29%. On multivariable analysis, longer hospital stay (hazard ratio 1.37, 95% confidence interval 1.16-1.61, p<0.01) was associated with recurrent UES after RUER.
    UNASSIGNED: RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.
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  • 文章类型: Journal Article
    目的:本研究的目的是介绍一个机构的人工耳蜗再植入(CRI)的经验,评估手术挑战和术后结果,并提高CRI的成功率。
    方法:回顾性单机构研究。
    方法:三级医疗中心。
    方法:我们回顾性评估了2001年至2022年在三级中心治疗的76例再植入病例的数据。临床特征包括听力损失的病因,失败的类型,手术问题,和听觉言语表现进行了分析。使用分类听觉表现(CAP)和语音清晰度等级(SIR)评分来评估CRI前后的结果。
    结果:CRI人群包括来自我们研究所的7名患者,69名来自其他中心的转诊患者。设备故障是CRI最常见的原因(68/76,89.5%);此外,有7例医疗故障,1例同时出现软装置故障。医疗失败包括皮瓣破裂和设备挤压,磁铁迁移,听神经病,白质脑病,异物残留和脑膜炎.在21/76患者中,电极技术升级。平均失败时间为0.58-13年,平均4.97年。CRI前后的平均(±SD)CAP和SIR评分分别为5.2±1.2和5.5±1.1和3.4±1.1和3.5±1.1。6例严重耳蜗畸形患者表现不佳,听觉神经发育不良,白质脑病,和癫痫。
    结论:CRI手术是一项具有挑战性但相对安全的手术,大多数再植入患者术后结局良好.内科并发症和耳蜗内损伤是术后效果不佳的主要原因。因此,为了获得最佳效果,应进行充分的术前准备和无创伤CRI.
    OBJECTIVE: The aim of this study was to present an institution\'s experience with cochlear reimplantation (CRI), to assess surgical challenges and post-operative outcomes and to increase the success rate of CRI.
    METHODS: Retrospective single-institution study.
    METHODS: Tertiary medical center.
    METHODS: We retrospectively evaluated data from 76 reimplantation cases treated in a tertiary center between 2001 and 2022. Clinical features including etiology of hearing loss, type of failure, surgical issues, and auditory speech performance were analyzed. Categorical Auditory Performance (CAP) and Speech Intelligibility Rating (SIR) scores were used to evaluate pre- and post-CRI outcomes.
    RESULTS: The CRI population comprises of 7 patients from our institute,69 referred patients from other centers. Device failure was the most common reason (68/76, 89.5 %) for CRI; in addition, there were 7 medical failures and 1 had both soft device failure. Medical failures included flap rupture and device extrusion, magnet migration, auditory neuropathy, leukoencephalopathy, foreign-body residue and meningitis. In 21/76 patients, the electrode technology was upgraded. The mean time to failure was 0.58-13 years, with a mean of 4.97 years. The mean (± SD) CAP and SIR scores before and after CRI were 5.2 ± 1.2 versus 5.5 ± 1.1 and 3.4 ± 1.1 versus 3.5 ± 1.1, respectively. Performance was poor in six patients with severe cochlear malformation, auditory nerve dysplasia, leukoencephalopathy, and epilepsy.
    CONCLUSIONS: CRI surgery is a challenging but relatively safe procedure, and most reimplanted patients experience favorable postoperative outcomes. Medical complications and intracochlear damage are the main causes of poor postoperative results. Therefore, adequate preoperative preparation and atraumatic CRI should be carried out for optimal results.
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  • 文章类型: Journal Article
    尽管结果很有希望,在修复冠状动脉异常的多种方法中,冠状动脉再植入似乎已被遗忘。我们描述了2018年至2023年在波哥大的两个机构中使用这种技术进行手术治疗的12例来自Valsalva对面窦的异常右冠状动脉患者的结果。哥伦比亚。我们提供了冠状动脉再植入作为一种更合适的技术的价值的初步证据,特别是在资源受限的环境中。它提供了高的症状控制率和功能类恢复率,同时评估所有潜在的高风险特征,并发症的风险很低,即使是中年患者。我们还提倡在决策中使用非侵入性解剖描述和患者症状而不是诱导型缺血测试。
    Despite promising results, reimplantation appears to have fallen into oblivion among the multiple possible approaches for repairing anomalous coronary arteries. We describe the outcomes of 12 patients with an anomalous right coronary artery originating from the opposite sinus of Valsalva with an interarterial course who were surgically treated with this technique between 2018 and 2023 in 2 institutions in Bogota, Colombia. We provide preliminary evidence of the value reimplantation as a more than suitable technique, particularly in resource-constrained settings. It offers high rates of control of symptoms and functional class recovery while assessing all potential high-risk features, with a low risk of complications, even in middle-aged patients. We also advocate using noninvasive anatomical descriptions and patient symptoms over inducible ischaemia tests in decision making.
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  • 文章类型: Journal Article
    尽管目前再植入是一种常见的治疗方法,文献中关于再植入成功或失败的信息很少。本研究的目的是评估在先前失败的植入物部位进行的牙科植入物的存活率,并确定与治疗结果相关的因素。
    这项回顾性研究基于2011年至2022年间在大学牙科诊所中使用牙科植入物进行修复的患者队列,这些患者为BigMouth网络提供数据。包括在相同部位替换先前失败的植入物的植入物。第一次和第二次再植入的病例包括有关患者特征的信息,包括年龄,性别,种族,种族,烟草使用,并从患者档案中提取全身医疗状况。
    筛选了20,842名患者在12年内放置的50,333个牙科植入物的记录。在284名患者中放置的三百70个植入物被同一部位的另一个植入物替换。首次植入植入物的累计存活率为98.6%,第一次置换率为96.1%,第二次置换率为91.7%.首次再植入的失败风险显著高于初始植入(P<0.001)。同样,与初始植入相比,二次植入的失败风险显著增加(P=0.05).在替换植入物失败与评估的任何患者相关参数之间未检测到显着关联(P>0.05)。
    在本研究的局限性内,替代失败种植体的牙种植体的存活率低于先前尝试植入种植体的存活率。未发现植入物失败的风险指标。其他因素应在未来的研究中进行研究。
    UNASSIGNED: Although reimplantation is currently a common treatment procedure, little information on reimplantation success or failure is available in the literature. The purpose of the present investigation was to evaluate the survival rate of dental implants that were performed in sites of previously failed implants and identify factors associated with the treatment outcome.
    UNASSIGNED: This retrospective study is based on a cohort of patients rehabilitated with dental implants in the dental clinics of the universities contributing data to the BigMouth network between 2011 and 2022. Implants replacing a previously failed implant at the same site were included. Cases of first and second reimplantations were included Information regarding patients\' characteristics including age, gender, ethnicity, race, tobacco use, and systemic medical conditions were extracted from patients\' files.
    UNASSIGNED: Records of 50,333 dental implants placed in 20,842 patients over a 12-year period were screened. Three hundred seventy implants placed in 284 patients were replaced by another implant at the same site. The cumulative survival rates of implants inserted for the first time was 98.6 %, for the first replacements was 96.1 % and for the second replacements was 91.7 %. First reimplants exhibited a significantly higher risk of failure than initial implantation (P < 0.001). Similarly, second reimplants demonstrated significantly greater risk of failure (P = 0.05) when compared to initial implants. No significant associations were detected between replaced implant failures with any of the patient related parameters evaluated (P > 0.05).
    UNASSIGNED: Within the limitations of the present study, dental implants replacing failed implants exhibited lower survival rates than the rates reported for the previous attempts of implant placement. No risk indicators for implant failure were identified. Additional factors should be examined in future studies.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    我们的目的是调查围手术期结局的差异,尤其是输尿管肠系膜狭窄,在机器人辅助根治性膀胱切除术(RARC)和回肠导管时接受了输尿管肠管支架吻合术的患者与未接受的患者之间。
    对我们的RARC数据库进行了回顾性审查(2009-2023年)。患者分为接受输尿管肠管支架吻合术的患者和未接受支架吻合术的患者。在年龄方面,以3(支架输尿管肠吻合)与1(无支架)的比例进行倾向评分匹配,性别,BMI,种族,美国麻醉医师协会评分,新辅助化疗,Charlson合并症指数,先前的放射治疗,既往腹部手术史,临床T3/临床T4分期,术前转移,术前肾积水.使用累积发生率曲线来描绘输尿管肠系膜狭窄,并使用Cox回归模型来识别与输尿管肠系膜狭窄相关的变量。
    488名患者接受了RARC,366人接受了输尿管肠管支架吻合术,122例患者接受了无支架入路。90天总体并发症没有显着差异,严重并发症,再入院,UTI,泄漏,肠梗阻(P>0.05)。在1年和2年,输尿管肠系膜狭窄的发生率分别为13%和18%。分别在支架组中,无支架组分别为7%和10%(P=0.05)。支架放置与输尿管肠系膜狭窄显着相关。
    无支架输尿管肠吻合与RARC和回肠导管后狭窄较少相关。
    UNASSIGNED: We aimed to investigate the differences in perioperative outcomes, especially ureteroenteric strictures, between patients who underwent a stented ureteroenteric anastomosis at the time of robot-assisted radical cystectomy (RARC) and ileal conduit vs those who did not.
    UNASSIGNED: A retrospective review of our RARC database was performed (2009-2023). Patients were divided into those who received stented ureteroenteric anastomosis vs those who did not. Propensity score matching was performed in the ratio of 3 (stented ureteroenteric anastomosis) to 1 (stent-free) in terms of age, gender, BMI, race, American Society of Anesthesiologists score, neoadjuvant chemotherapy, Charlson Comorbidity Index, prior radiation therapy, previous abdominal surgery history, clinical T3/clinical T4 stage, preoperative metastasis, and preoperative hydronephrosis. A cumulative incidence curve was used to depict ureteroenteric strictures and a Cox regression model was used to identify variables associated with ureteroenteric strictures.
    UNASSIGNED: Four hundred eighty-eight patients underwent RARC, 366 individuals underwent a stented ureteroenteric anastomosis, and 122 patients underwent a stent-free approach. There was no significant difference in 90-day overall complications, high-grade complications, readmissions, UTIs, leakage, and ileus (P > .05). Ureteroenteric strictures occurred at a rate of 13% and 18% at 1 and 2 years, respectively in the stented group, vs 7% and 10% in the stent-free group (P = .05). Stent placement was significantly associated with ureteroenteric strictures.
    UNASSIGNED: Stent-free ureteroenteric anastomosis was associated with fewer strictures following RARC and ileal conduit.
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  • 文章类型: Journal Article
    全关节置换术是终末期骨关节炎患者的推荐治疗方法,因为它减少了残疾和疼痛,恢复了关节功能。然而,假体关节感染是该手术的严重并发症,两阶段交换是最常见的治疗方法。虽然在诊断人工关节感染方面存在共识,对于可以指导外科医生在两阶段手术中进行明确的再植入的参数缺乏一致意见.在确定的再植入之前,已经提出了一种提高微生物调查准确性的方法,即观察抗生素治疗的假期,以提高假体周围组织培养的准确性。但是这些文化报告了某种程度的特殊性。因此,几项证据表明,使用连续抗生素治疗进行再植入应被认为是一种安全有效的方法,导致更高的治愈率和更短的残疾期。C反应蛋白(CRP)剂量,红细胞沉降率(ERS)和D-二聚体有助于诊断人工关节感染,但只有D-二聚体在预测两阶段手术后感染复发的风险方面表现出足够的准确性.在再植入前的滑液分析已被证明是最准确的预测复发。白细胞计数和中性粒细胞百分比的新临界值显示了一个有用的预测规则,可以识别有不良结局风险的患者。一种基于通过D-二聚体水平的多变量分析得出的β系数计算出的数字分数的新评分系统,滑液白细胞和相对中性粒细胞百分比在指导两阶段程序的第二步时显示出很高的准确性。总之,对于没有局部症状的连续治疗患者,重新植入可能是一个合适的选择,CRP和ERS在正常范围内,滑液白细胞低(<952/mL),中性粒细胞百分比低(<52%),D-二聚体低于1100µg/mL。通过分析这三个参数得出的数值分数可以用作确定这些患者中再植入的可行性的有价值的工具。
    Total joint arthroplasty is the recommended treatment for patients with end-stage osteoarthritis, as it reduces disability and pain and restores joint function. However, prosthetic joint infection is a serious complication of this procedure, with the two-stage exchange being the most common treatment method. While there is consensus on diagnosing prosthetic joint infection, there is a lack of agreement on the parameters that can guide the surgeon in performing definitive reimplantation in a two-stage procedure. One approach that has been suggested to improve the accuracy of microbiologic investigations before definitive reimplantation is to observe a holiday period from antibiotic therapy to improve the accuracy of cultures from periprosthetic tissues, but these cultures report some degree of aspecificity. Therefore, several pieces of evidence highlight that performing reimplantation using continuous antibiotic therapy should be considered a safe and effective approach, leading to higher cure rates and a shorter period of disability. Dosage of C-reactive protein (CRP), erythrocyte sedimentation rate (ERS) and D-dimer are helpful in diagnosing prosthetic joint infection, but only D-dimer has shown sufficient accuracy in predicting the risk of infection recurrence after a two-stage procedure. Synovial fluid analysis before reimplantation has been shown to be the most accurate in predicting recurrence, and new cutoff values for leukocyte count and neutrophil percentage have shown a useful predictive rule to identify patients at risk of unfavourable outcome. A new scoring system based on a numerical score calculated from the beta coefficient derived through multivariate analysis of D-dimer levels, synovial fluid leukocytes and relative neutrophils percentage has demonstrated high accuracy when it comes to guiding the second step of two-stage procedure. In conclusion, reimplantation may be a suitable option for patients who are on continuous therapy without local symptoms, and with CRP and ERS within the normal range, with low synovial fluid leukocytes (< 952/mL) and a low relative neutrophil percentage (< 52%) and D-dimer below 1100 µg/mL. A numerical score derived from analysing these three parameters can serve as a valuable tool in determining the feasibility of reimplantation in these patients.
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  • 文章类型: Journal Article
    背景:两阶段假体交换是全髋关节置换术(THA)的慢性假体周围感染(PJI)的治疗选择,特别是当骨骼和周围软组织受损或涉及难以治疗的病原体时。
    目的:(1)确定THA后两阶段假体置换治疗PJI的结果;(2)确定再植入后再感染导致后续翻修手术的危险因素。
    方法:我们前瞻性招募了187名连续患者,这些患者在2013年至2019年期间接受了两个阶段的THA交换并进行了PJI切除术。随访时间的平均值(±SD[标准差])为54.2±24.9个月(范围,36至96),直到再植入的平均间隔为9.8±8.9周(范围,2至38)。在两个治疗阶段之间,所有患者均处于无间隔物的情况。在两阶段治疗后保持无感染的患者被认为已获得治疗成功。
    结果:总成功率为85.6%。再植入后一年后再感染的累积概率为11.5%,两年后为14%。高毒力或DTT(难以治疗)病原体是再感染的显着和独立的危险因素(HR[风险比]=3.71,95%CI[置信区间]:1.47至9.36,P=0.006和HR=3.85,95%CI:1.73至8.57,分别P=0.001),与之前的两阶段髋关节假体交换一样(HR=3.58,95%CI:1.33至9.62,P=0.01)。总体再手术率和翻修率分别为26.2%和16.6%,分别。再次感染患者再次手术的概率比未感染患者高80%(P<0.001,log-rank=102.6),他们在随访期间接受翻修手术的可能性增加了55%(P<0.001,log-rank=55.4)。
    结论:PJI两阶段无间隔区THA翻修后的再感染率仍然很高,但可与包括水泥垫片在内的那些相媲美。先前两阶段植入物更换失败或被高级或难以治疗的病原体感染的患者处于治疗失败的高风险中。
    BACKGROUND: Two-stage prosthesis exchange is the treatment of choice for chronic periprosthetic joint infection (PJI) of a total hip arthroplasty (THA), especially when the bone and surrounding soft tissues are compromised or difficult-to-treat pathogens are implicated. The aims of our study were as follows: (1) to determine the outcome of 2-stage prosthesis exchange for the treatment of PJI after THA and (2) to determine the risk factors for reinfection leading to subsequent revision surgeries after reimplantation.
    METHODS: We prospectively enrolled 187 consecutive patients who underwent a 2-stage THA exchange with resection arthroplasty for PJI from 2013 to 2019. The mean (± SD) duration of follow-up was 54.2 ± 24.9 months (range, 36 to 96), and the mean interval until reimplantation was 9.8 ± 8.9 weeks (range, 2 to 38). All patients remained in a spacer-free girdlestone situation between the 2 stages of treatment. Patients who remained infection-free after their 2-stage treatment were considered to have achieved treatment success.
    RESULTS: The overall success rate was 85.6%. The cumulative probability of reinfection was 11.5% after one year and 14% after 2 years after reimplantation. High virulence or difficult-to-treat pathogens were significant and independent risk factors for reinfection (HR [hazard ratio] = 3.71, 95% CI [confidence interval]: 1.47 to 9.36, P = .006 and HR = 3.85, 95% CI: 1.73 to 8.57, respectively, P = .001), as was previous 2-stage hip prosthesis exchange (HR = 3.58, 95% CI: 1.33 to 9.62, P = .01). Overall reoperation and revision rates were 26.2 and 16.6%, respectively. Re-infected patients had an 80% higher probability of reoperation than noninfected ones (P < .001, log-rank = 102.6), and they were 55% more likely to undergo revision surgery during their follow-up (P < .001, log-rank = 55.4).
    CONCLUSIONS: Reinfection rates after 2-stage spacer-free THA revision for PJI still remain high but are comparable to those including cement spacers. Patients who have had prior failed 2-stage implant exchanges or are infected by high-grade or difficult-to-treat pathogens are at high risk for treatment failure.
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  • 文章类型: Journal Article
    目的:比较膝关节翻修术的再植入阶段的冷冻切片(FS)结果,在没有临床感染体征但术前血清炎症标志物不确定的患者中。
    方法:在手术后的第二天再次检查切片。当根据肌肉骨骼感染国际共识的共识标准确定5个独立的高倍视野中存在>5个多形核中性粒细胞(PMNLs)时,术中FS(iFS)被认为是阳性。临床结果,分析了iFS和综述FS(rFS)的培养和诊断价值。
    结果:在接受评估的78例患者中,66例(84.6%)患者在再植后没有出现并发症。12例患者出现并发症,其中六人接受了重新移植治疗,四个进行关节固定术,两个进行膝盖以上截肢。iFS和rFS的敏感性和特异性均不显著(25%和45.5%,25%和45%,分别)。最终培养与iFS和rFS之间没有统计学上的显着差异。
    结论:iFS评估不足以排除假体周围关节感染(PJI)的恢复。由于大量纤维化,难以进行适当的组织取样,因此在植入和植入间隔之间血清炎症标志物不确定的患者中,感染复发的诊断仍然具有挑战性。主治医师应密切监测临床表现。
    OBJECTIVE: To compare Frozen Section (FS) results during the reimplantation stage of revision knee arthroplasty, in patients without clinical signs of infection but with preoperative inconclusive serum inflammatory markers.
    METHODS: Sections were revisited the day after surgery. Intraoperative FS (iFS) was accepted as positive when the presence of >5 polymorphonuclear neutrophils (PMNLs) in 5 separate high-power fields was determined according to the consensus criteria of the International Consensus on Musculoskeletal Infection. The clinical outcomes, cultures and diagnostic values of iFS and review FS (rFS) were analyzed.
    RESULTS: No complications developed after reimplantation in 66 (84.6%) of the 78 evaluated patients. Complications developed in 12 patients, six of whom were treated with re-explantation, four with arthrodesis and two with above-the-knee amputation. Both iFS and rFS yielded insignificant sensitivity and specificity (25% and 45.5%, 25% and 45%, respectively). There was no statistically significant difference between definitive culture and iFS and rFS.
    CONCLUSIONS: iFS evaluation is insufficient to exclude recovery from periprosthetic joint infection (PJI). Diagnosis of recurrence of infection in patients with indefinite serum inflammatory markers between the explantation and reimplantation interval remains challenging due to massive fibrosis that makes proper tissue sampling difficult. The attending physician should closely monitor clinical findings.
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