■经典霍奇金淋巴瘤的发病率为每100,000人中2-3例,在0.02%的病例中会影响中枢神经系统(Gerstner等人。,2008;Brice等人。,2021年;Morawa等人。,2007).中枢神经系统淋巴瘤,占中枢神经系统肿瘤的0.22%,是霍奇金病的罕见结外表现(Brice等人。,2021年;亨肯贝伦斯等人。,2014).它影响继发于全身性淋巴瘤或疾病复发的神经系统(Gerstner等人。,2008).仅报道了17例CNS淋巴瘤,在诊断时仅限于CNS(Paul等人。,2017)。文献中仅报道了2例基于硬脑膜的霍奇金淋巴瘤(Paul等人。,2017)。
方法:我们报告了第3例33岁女性的硬脑膜附着轴外继发性中枢神经系统霍奇金淋巴瘤,出现并作为左蝶骨翼脑膜瘤进行手术。
■仅报告了17例中枢神经系统淋巴瘤,在诊断时仅限于中枢神经系统(Paul等人。,2017)。文献中仅报道了2例基于硬脑膜的霍奇金淋巴瘤(Paul等人。,2017)。我们的病例包括第三例硬脑膜附着的经典CNS霍奇金淋巴瘤和第一例位于蝶骨翼的经典CNS霍奇金淋巴瘤。
结论:将中枢神经系统霍奇金淋巴瘤与其他类型的脑肿瘤区分开来很重要,尤其是当它位于不寻常的位置时,因为中枢神经系统霍奇金淋巴瘤的治疗主要是联合放化疗,而不是手术干预。
UNASSIGNED: Classic Hodgkin Lymphoma with an incidence of 2-3 cases per 100,000 population affects the Central Nervous System in 0.02 % of cases (Gerstner et al., 2008; Brice et al., 2021; Morawa et al., 2007). CNS lymphoma, contributing to 0.22 % of Central Nervous System tumors, is the uncommon extra-nodal manifestation of Hodgkin\'s Disease (Brice et al., 2021; Henkenberens et al., 2014). It affects the nervous system secondary to systemic lymphoma or the relapse of the disease (Gerstner et al., 2008). Only 17 cases of CNS lymphoma are reported which were limited to the CNS at the time of diagnosis (Paul et al., 2017). Only two cases of Dural-Based Hodgkin Lymphoma were reported in the literature (Paul et al., 2017).
METHODS: We are reporting the third case of dural-attached extra-axial secondary CNS Hodgkin Lymphoma in a 33 years old female, which appeared and was operated as Left Sphenoid Wing Meningioma.
UNASSIGNED: Only 17 cases of CNS lymphoma are reported which were limited to the CNS at the time of diagnosis (Paul et al., 2017). Only two cases of Dural-Based Hodgkin Lymphoma were reported in the literature (Paul et al., 2017). Our case consists the third case of dural attached Classic CNS Hodgkin lymphoma and the first case of Classic CNS Hodgkin Lymphoma locating in the Sphenoid Wing.
CONCLUSIONS: It is important to differentiate CNS Hodgkin Lymphoma from other types of brain tumors especially when it resides in an unusual location because the treatment of CNS Hodgkin Lymphoma is mainly combined chemo-radiotherapy than surgical intervention.