目的:帕金森病(PD)是一种以震颤为特征的最常见的神经退行性疾病,刚性,运动迟缓和姿势障碍。研究表明,葡萄汁和运动可能对神经退行性疾病有有益的影响。因此,在本研究中,我们评估了红葡萄汁(GJ)和跑步机对PD动物模型的影响。材料与方法:30只雄性Wistar大鼠随机分为假手术组,PD,用GJ(PD-GJ)处理的PD,运动治疗的PD(PD-Ex),和用与运动相关的GJ治疗的PD(PD-GJ-Ex)组,每组6只大鼠。为了获得PD模型,将6-OHDA注入左侧黑质。为了证明病变产生并估计其范围,给予阿朴吗啡(i.p.),并在60分钟内记录诱导旋转的总数。通过跑步机进行运动,并将GJ添加到饮用水中30天,然后再次进行旋转测试。
结果:我们的结果表明,PD组和Sham组之间的旋转次数存在显着差异(p<0.05)。实验结束时,PD-GJ组和PD-GJ-Ex组的旋转次数均显著减少(p<0.05)。运动本身不显著增加旋转次数。
结论:葡萄汁可能通过抗氧化剂减少旋转。
OBJECTIVE: Parkinson(\')s disease (PD) is one of the most common neurodegenerative disorders which is characterized by tremor, rigidity, bradykinesia and postural disturbances. Studies indicate that grape juice and exercise may have beneficial effects on neurodegenerative disorders. Therefore, in the present study, we evaluated the effects of red grape juice (GJ) together with treadmill running on animal model of PD. Materials and Methods : 30 male Wistar rats were divided randomly into Sham, PD, PD treated with GJ (PD-GJ), PD treated with exercise (PD-Ex), and PD treated with GJ associated with exercise (PD-GJ-Ex) groups with six rats in each. In order to obtain the PD model, 6-OHDA was infused into left substantia nigra pars compacta. In order to prove that the lesions are created and to estimate their extent, apomorphine was administered (i.p.) and total number of induced rotations was recorded during 60 minutes. Exercise was applied by treadmill and GJ was added into drinking water for 30 days and rotations test was performed again.
RESULTS: Our results indicate that there was a significant difference in number of rotations between PD and Sham groups (p<0.05). At the end of experiment, number of rotations decreased significantly in both PD-GJ and PD-GJ-Ex groups (p<0.05). Exercise alone increased the number of rotations non- significantly.
CONCLUSIONS: Grape juice reduced rotations probably via the antioxidant agents.