精氨酸加压素(AVP)和催产素(OT)是众所周知的调节哺乳动物各种社会行为的神经肽。然而,人们对它们在小鼠女性性行为中的作用知之甚少。因此,我们研究了AVP(v1a和v1b)和OT受体对女性性行为的作用。首先,我们设计了一种新仪器,双层室,准确观察雌性小鼠的性行为。该仪器可以更精确地测量脊柱前凸作为接受性和排斥样行为(本研究中最新定义),相反的表现。为了解决我们的研究问题,我们评估了缺乏v1a(aKO)小鼠的雌性性行为,v1b(bKO),V1a和V1b(DKO),和OT(OTRKO)受体。aKO女性表现出减少的排斥样行为,但脊柱前凸的正常水平,而bKO女性几乎没有前凸,也没有排斥样行为的变化。此外,dKO女性表现出正常的脊柱前凸水平,这表明v1b受体促进脊柱前凸,但不一定,而v1a受体潜伏抑制它。相比之下,虽然OTRKO不影响脊柱前凸,它显著增加了类似拒绝的行为。总之,目前的结果表明,v1a受体抑制的性能和接受性,而v1b和OT受体促进接受性和可接受性,分别。
Arginine vasopressin (AVP) and oxytocin (OT) are well-known as neuropeptides that regulate various social behaviors in mammals. However, little is known about their role in mouse female sexual behavior. Thus, we investigated the role of AVP (v1a and v1b) and OT receptors on female sexual behavior. First, we devised a new apparatus, the bilevel chamber, to accurately observe female mouse sexual behavior. This apparatus allowed for a more precisely measurement of lordosis as receptivity and rejection-like behavior (newly defined in this study), a reversed expression of proceptivity. To address our research question, we evaluated female sexual behavior in mice lacking v1a (aKO), v1b (bKO), both v1a and v1b (dKO), and OT (OTRKO) receptors. aKO females showed decreased rejection-like behavior but a normal level of lordosis, whereas bKO females showed almost no lordosis and no change in rejection-like behavior. In addition, dKO females showed normal lordosis levels, suggesting that the v1b receptor promotes lordosis, but not necessarily, while the v1a receptor latently suppresses it. In contrast, although OTRKO did not influence lordosis, it significantly increased rejection-like behavior. In summary, the present results demonstrated that the v1a receptor inhibits proceptivity and receptivity, whereas the v1b and OT receptors facilitate receptivity and proceptivity, respectively.