心理压力影响神经内分泌调节,调节精神状态和行为。褪黑激素,一种主要由松果体合成的激素,调节许多大脑功能,包括昼夜节律,疼痛,睡眠,和心情。选择性药理学褪黑素激动剂ramelteon已在临床上用于治疗情绪和睡眠障碍。创伤后应激障碍(PTSD)是一种与严重创伤相关的精神疾病;它通常由创伤事件引发,导致严重的焦虑和无法控制的创伤回忆。我们最近报道,反复的社交失败压力(RSDS)可能会在小鼠中引起强烈的焦虑样行为和社交回避。在本研究中,我们研究了褪黑素和ramelteon激活褪黑素受体是否调节RSDS诱导的行为变化.褪黑素治疗改善了RSDS小鼠的社交回避和焦虑样行为。此外,非选择性MT1/MT2受体激动剂的治疗,Ramelteon,显著改善RSDS诱导的社交回避和焦虑样行为。此外,激活褪黑激素受体也平衡了单胺氧化酶的表达,糖皮质激素受体,和海马中的内源性抗氧化剂。一起来看,我们的研究结果表明,褪黑素和ramelteon的激活调节RSDS诱导的焦虑样行为和PTSD症状.目前的研究还表明,在反复的社会失败压力下,神经内分泌机制和认知行为对褪黑素受体激活的调节作用。
Psychological stress affects the neuroendocrine regulation, which modulates mental status and behaviors. Melatonin, a hormone synthesized primarily by the pineal gland, regulates many brain functions, including circadian rhythms, pain, sleep, and mood. Selective pharmacological melatonin agonist ramelteon has been clinically used to treat mood and sleep disorders. Posttraumatic stress disorder (PTSD) is a psychiatric condition associated with severe trauma; it is generally triggered by traumatic events, which lead to severe anxiety and uncontrollable trauma recall. We recently reported that repeated social defeat stress (RSDS) may induce robust anxiety-like behaviors and social avoidance in mice. In the present study, we investigated whether melatonin receptor activation by melatonin and ramelteon regulates RSDS-induced behavioral changes. Melatonin treatment improved social avoidance and anxiety-like behaviors in RSDS mice. Moreover, treatment of the non-selective MT1/MT2 receptor agonist, ramelteon, markedly ameliorated RSDS-induced social avoidance and anxiety-like behaviors. Moreover, activating melatonin receptors also balanced the expression of monoamine oxidases, glucocorticoid receptors, and endogenous antioxidants in the hippocampus. Taken together, our findings indicate that the activation of both melatonin and ramelteon regulates RSDS-induced anxiety-like behaviors and PTSD symptoms. The current study also showed that the regulatory effects of neuroendocrine mechanisms and cognitive behaviors on melatonin receptor activation in repeated social defeat stress.