背景:皮疹是常见的药物不良反应之一,在典型和非典型抗精神病药物中均有报道。鲁拉西酮诱导的皮肤反应的报道很少。在这项研究中,我们报告一例由lurasidone引起的皮疹。
方法:一名63岁患有双相情感障碍(BD)的男性患者,接受lurasidone治疗。然而,卢拉西酮剂量从40mg/天增加到60mg/天后,患者出现皮疹。随着药物引起的皮疹的诊断,Lurasidone被停用了,皮疹在2周内完全消失。此外,所有关于抗精神病药相关皮疹的病例报告都通过搜索英文和中文数据库进行审查,包括Pubmed,Embase,科克伦图书馆,CNKI与万方数据库我们的研究共纳入了139篇包含172名患者的文章。文献回顾和我们的案例表明,抗精神病药物引起的皮肤不良事件不容忽视,特别是对于首次使用或剂量增加抗精神病药的患者。
结论:结论:我们报告1例lurasidone相关皮疹和抗精神病药引起的复查皮疹。精神科医生应警惕抗精神病药引起皮疹的可能性,特别是患者首次使用抗精神病药或抗精神病药剂量正在增加。
BACKGROUND: Rash is one of common adverse drug reaction and which have been reported in typical and atypical antipsychotics. Reports of lurasidone induced skin reactions are sparse. In this study, we report a case of
rash caused by lurasidone.
METHODS: A 63-year-old man with bipolar disorder (BD) who is treated by lurasidone. However, the patient presents a
rash all over after lurasidone dose increasing from 40 mg/day to 60 mg/day. With the diagnosis of drug induced
rash, lurasidone was discontinued, and the
rash complete disappears within 2 weeks. In addition, all case reports about antipsychotics associated rash were reviewed by searching English and Chinese database including Pubmed, Embase, Cochrane Library, CNKI and Wanfang database. A total of 139 articles contained 172 patients were included in our study. The literature review and our case suggest that the cutaneous adverse events caused by antipsychotic drugs should not be ignored, particularly for the patient who was first use or at dose increasing of antipsychotic.
CONCLUSIONS: In conclusion, we report a case of lurasidone related
rash and review
rash caused by antipsychotics. Psychiatrists should be alert to the possibility of the rash caused by antipsychotics, especially the patient was first use of antipsychotics or the antipsychotic dose was increasing.