未经证实:血管内大B细胞淋巴瘤(IVLBCL)的延迟诊断与预后不良有关,使早期诊断和治疗至关重要。然而,早期诊断仍然具有挑战性。
未经授权:这里我们介绍一个75岁的男性不明原因发热的病例,随机皮肤活检(RSB)允许早期诊断IVLBCL。
未经批准:RSB的有用性,这涉及对三个或更多含有皮下脂肪组织的部位进行切开的皮肤活检,比如大腿,腹部和上臂,已经被辩论了。在疑似IVLBCL的病例中,RSB比内脏器官的活检侵入性更小。
UNASSIGNED:我们建议将RSB与骨髓检查相结合可能有助于诊断IVLBCL。
结论:血管内大B细胞淋巴瘤(IVLBCL)的延迟诊断与不良预后有关,但是由于其多样性,早期诊断很困难,非特定演示。该病例报告说明了随机皮肤活检在IVLBCL早期诊断中的价值,该患者患有不明原因的发烧和无淋巴结肿大的血液学异常。脾肿大或骨髓异常。随机皮肤活检的诊断准确性取决于几个因素,包括活检部位的位置和数量,以及活检的深度和宽度。
UNASSIGNED: Delayed diagnosis of intravascular large B-cell lymphoma (IVLBCL) is associated with a poor prognosis, making early diagnosis and treatment essential. However, early diagnosis remains challenging.
UNASSIGNED: Here we present the case of a 75-year-old man with fever of unknown origin, in whom random skin biopsy (RSB) allowed early diagnosis of IVLBCL.
UNASSIGNED: The usefulness of RSB, which involves incisional skin biopsies of three or more sites that contain subcutaneous fatty tissue, such as the thighs, abdomen and upper arms, has been debated. In cases of suspected IVLBCL, RSB is less invasive than a biopsy of the internal organs.
UNASSIGNED: We suggest that combining RSB with bone marrow examination may facilitate the diagnosis of IVLBCL.
CONCLUSIONS: Delayed diagnosis of intravascular large B-cell lymphoma (IVLBCL) is associated with a poor prognosis, but early diagnosis is difficult due to its diverse, non-specific presentation.This case report illustrates the value of random skin biopsy in the early diagnosis of IVLBCL in a man with fever of unknown origin and haematological abnormalities without lymphadenopathy, splenomegaly or bone marrow abnormalities.The diagnostic accuracy of random skin biopsy depends on several factors, including the location and number of sites biopsied, and the depth and width of the biopsy.