背景:放射治疗(RT)是一种广泛使用的肿瘤治疗方法,而这种治疗方式的主要障碍是肿瘤细胞表现出的放射抗性。为了提高RT的有效性,科学家们已经探索了放射增敏方法,包括使用放射增敏剂和物理刺激。然而,几种方法表现出令人失望的结果,包括不良反应和疗效有限.一种更安全,更有效的放射增敏方法涉及低强度超声(LIUS),选择性靶向肿瘤组织并增强放射治疗的疗效。
方法:本文总结了肿瘤放射抗性的原因,并探讨了LIUS潜在的放射增敏机制。此外,它涵盖了LIUS在放射增敏方面的不同应用策略,包括单独使用LIUS,超声靶向血管内微气泡破坏,超声介导的靶向放射增敏剂递送,和声动力疗法。最后,该综述介绍了在临床环境中采用LIUS-RT联合治疗的局限性和前景,强调需要将研究成果与实际应用联系起来。
结论:LIUS采用具有成本效益的设备来促进肿瘤放射增敏,减少辐射暴露,提高患者的生活质量。这种功效归因于LIUS利用热量的能力,空化,和机械效应来克服肿瘤细胞对RT的抗性。多项实验分析强调了LIUS使用多种策略诱导肿瘤放射增敏的有效性。虽然初步研究显示出了有希望的结果,进行更全面的临床试验对于确认其在现实世界中的安全性和有效性至关重要。
BACKGROUND: Radiotherapy (RT) is a widely utilized tumor treatment approach, while a significant obstacle in this treatment modality is the radioresistance exhibited by tumor cells. To enhance the effectiveness of RT, scientists have explored
radiosensitization approaches, including the use of radiosensitizers and physical stimuli. Nevertheless, several approaches have exhibited disappointing results including adverse effects and limited efficacy. A safer and more effective method of
radiosensitization involves low-intensity ultrasound (LIUS), which selectively targets tumor tissue and enhances the efficacy of radiation therapy.
METHODS: This review summarized the tumor radioresistance reasons and explored LIUS potential radiosensitization mechanisms. Moreover, it covered diverse LIUS application strategies in
radiosensitization, including the use of LIUS alone, ultrasound-targeted intravascular microbubble destruction, ultrasound-mediated targeted radiosensitizers delivery, and sonodynamic therapy. Lastly, the review presented the limitations and prospects of employing LIUS-RT combined therapy in clinical settings, emphasizing the need to connect research findings with practical applications.
CONCLUSIONS: LIUS employs cost-effective equipment to foster tumor
radiosensitization, curtail radiation exposure, and elevate the quality of life for patients. This efficacy is attributed to LIUS\'s ability to utilize thermal, cavitation, and mechanical effects to overcome tumor cell resistance to RT. Multiple experimental analyses have underscored the effectiveness of LIUS in inducing tumor
radiosensitization using diverse strategies. While initial studies have shown promising results, conducting more comprehensive clinical trials is crucial to confirm its safety and effectiveness in real-world situations.