背景:致癌Ras相关GTP结合蛋白,被称为Rabs,以它们与上游复杂的相互作用为特征,下游分子,尤其是,细胞外囊泡(EV)。虽然广泛的Rabs家族及其相关的信号通路已经被详尽地解剖,Rab22a成为一个未偿利益实体,由于其在许多生物学过程中的强大影响以及与癌症转移和迁移的显着相关性。在肿瘤学领域中,Rab22a和EV之间的相互作用引起了越来越多的兴趣,这突显了进行更深入的评论和学术话语的必要性。
方法:我们根据已发表的与Rab22a相关的原创和评论文章进行了评论,肿瘤,microRNA,exosome,微泡,电动汽车,CD147溶酶体,降解,内体再循环,等。从PubMed,WebofScience和GoogleScholar数据库。
结论:我们总结了控制Rab22a和Rab22a突变体表达的调控过程。值得注意的是,强调了目前对Rab22a和电动汽车之间复杂相互作用的理解,涵盖了Rab22a对EV起源的影响以及受Rab22a突变体影响的EV在推动肿瘤进展中的作用。Rab22a和EV之间的动态相互作用在肿瘤的进展中起着重要作用,它可以为癌症的发病机制和开发新的治疗靶点提供新的见解。
BACKGROUND: Oncogenic Ras-related GTP-binding proteins, referred to as Rabs, are characterized by their intricate interactions with upstream, downstream molecules, and notably, extracellular vesicles (EVs). While the expansive family of Rabs and their associated signaling pathways have been exhaustively dissected, Rab22a emerges as an entity of outstanding interest, owing to its potent influence in many biological processes and its conspicuous correlation with cancer metastasis and migration. A burgeoning interest in the interactions between Rab22a and EVs in the field of oncology underscores the necessity for more in-depth reviews and scholarly discourses.
METHODS: We performed a review based on published original and review articles related to Rab22a, tumor, microRNA, exosome, microvesicles, EVs, CD147, lysosome, degradation, endosomal recycling, etc. from PubMed, Web of Science and Google Scholar databases.
CONCLUSIONS: We summarize the regulatory processes governing the expression of Rab22a and the mutants of Rab22a. Notably, the present understanding of complex interactions between Rab22a and EVs are highlighted, encompassing both the impact of Rab22a on the genesis of EVs and the role of EVs that are affected by Rab22a mutants in propelling tumor advancement. The dynamic interaction between Rab22a and EVs plays a significant role in the progression of tumors, and it can provide novel insights into the pathogenesis of cancers and the development of new therapeutic targets.