UNASSIGNED:本研究的目的是在治疗计划期间考虑和计算剂量学参数,以改善接受高剂量率(HDR)腔内近距离放射治疗(ICBT)的宫颈癌患者的放射生物学结果。
未经批准:在本研究中,分析了30例使用基于计算机断层扫描(CT)的计划进行HDR近距离放射治疗的宫颈癌患者的剂量体积直方图(DVH).高危临床目标体积(HR-CTV)作为所有患者的主要目标体积,假设在近距离放射治疗时不存在肉眼肿瘤。目标覆盖率值(100%,150%,200%)是从DVH获得的,用于计算不同的质量指标(QI),包括覆盖指数(CI),剂量均匀性指数(DHI),过量体积指数(ODI),和剂量不均匀比(DNR)。这些QI的值进一步用于计算肿瘤控制概率(TCP)。建立了所有QI与TCP之间的统计相关性。此外,计算膀胱(NTCP_B)和直肠(NTCP_R)的正常组织并发症的概率。
UNASSIGNED:各种计算参数的平均值,包括CI、DHI、ODI,DNR,TCP,NTCP_B和NTCP_R分别为0.92±0.07、0.26±0.10、0.50±0.10、0.74±0.10、0.92±0.07、0.08±0.25和0.36±0.27。皮尔逊积矩在CI、DHI、ODI,关于TCP的DNR分别为+0.85、-0.85、+0.84和+0.85。
UNASSIGNED:发现剂量学和放射生物学参数之间的相关性具有统计学意义,这表明剂量学参数对放射生物学结果的影响。因此,在制定治疗计划时应考虑这些参数,以改善放射生物学结果.
UNASSIGNED: The purpose of the study was to consider and calculate dosimetric parameters during treatment planning to improve radiobiological outcomes for cervical cancer patients treated with high-dose-rate (HDR) intracavitary brachytherapy (ICBT).
UNASSIGNED: In the present study, dose volume histograms (DVH) of 30 cervical cancer patients treated with HDR brachytherapy using computer tomography (CT)-based planning were analyzed. High-risk clinical target volume (HR-CTV) was contoured as the main target volume for all the patients, with an assumption that there was no presence of gross tumor at the time of brachytherapy. Values of target coverage volumes (100%, 150%, and 200%) were obtained from DVH, which was used to calculate different quality indices (QIs), including coverage index (CI), dose homogeneity index (DHI), overdose volume index (ODI), and dose non-uniformity ratio (DNR). Values of these QIs were further used to calculate tumor control probability (TCP). Statistical correlation between all QIs with TCP was established. Also, normal tissue complication probabilities for bladder (NTCP_B) and rectum (NTCP_R) were calculated.
UNASSIGNED: The mean values of the various calculated parameters, including CI, DHI, ODI, DNR, TCP, NTCP_B and NTCP_R were 0.92 ±0.07, 0.26 ±0.10, 0.50 ±0.10, 0.74 ±0.10, 0.92 ±0.07, 0.08 ±0.25, and 0.36 ±0.27, respectively. Pearson\'s product moment correlation coefficient between CI, DHI, ODI, and DNR with regards to TCP was +0.85, -0.85, +0.84, and +0.85, respectively.
UNASSIGNED: The correlation between dosimetric and radiobiological parameters was found statistically significant, which shows the influence of dosimetric parameters on the radiobiological outcome. Therefore, these parameters should be considered during the treatment planning to improve the radiobiological outcome.