■治疗皮肤癌的主要方法包括手术,尽管在患者自行拒绝治疗或不符合手术条件的情况下,根治性放疗(RT)可被视为替代选择。在此,我们根据在不符合手术资格的患者中使用大分割QUADSHOTRT来评估单机构材料。
在2019年12月至2022年12月期间,9名局部晚期非黑色素瘤皮肤癌患者被取消手术资格,因此在Radom肿瘤学中心接受了治疗。波兰。患者接受肿瘤放射治疗组8502QUADSHOT方案(14.8Gy/4分,每天两次治疗,间隔6小时,连续2天)。使用体积调节电弧疗法(VMAT)每4周重复疗程3次。
■在9名患者中有4名(44.4%)观察到2级毒性,未观察到≥3级急性毒性.中位年龄为79.1(60-98)岁。照射面积如下:鼻皮(2),脸颊(2),眉毛与眼睑(1),前额(1),寺庙(1),胸骨(1),和肩胛骨(1)。表现状况如下:WHOII-5名患者(55.6%),世卫组织I-3名患者,WHOIII-一名患者。一名患者在2个地区接受了3个RT疗程,共6个疗程,6例患者接受了3个疗程的治疗,2例患者接受2个疗程。此外,截至2023年3月14日,4例患者死于非恶性原因.
■使用VMATRT的QUADSHOT时间表可能是一种有效的姑息治疗方法,具有良好的反应率,这对局部晚期非黑色素瘤皮肤癌患者的生活质量有积极影响。
UNASSIGNED: The primary approach for managing skin cancer involves surgery, although radical radiotherapy (RT) may be considered as an alternative option in cases where patients decline the treatment themselves or are not eligible for surgical intervention. Herein we assess single-institution material in terms of the use of hypofractionated QUAD SHOT RT in patients disqualified from surgery.
UNASSIGNED: Between December 2019 and December 2022, nine patients with locally advanced non-melanoma skin cancer were disqualified from surgery and as a result were treated at the Radom Oncology Centre, Poland. Patients were treated with the Radiation Therapy Oncology Group 8502 QUAD SHOT regimen (14.8 Gy/4 fractions, twice-daily treatment with a 6 h interval, on 2 consecutive days). Courses were repeated every 4 weeks 3 times using volumetric modulated arc therapy (VMAT).
UNASSIGNED: Grade 2 toxicities were observed in 4 of 9 (44.4%) patients, no grade ≥ 3 acute toxicity was observed. The median age was 79.1 (60-98) years. Irradiated areas were as follows: nose skin (2), cheek (2), eyebrow with eyelid (1), forehead (1), temple (1), sternum (1), and scapula (1). Performance status was as follows: WHO II - 5 patients (55.6%), WHO I - 3 patients, WHO III - one patient. One patient underwent 3 RT courses in 2 areas for a total of 6 treatment courses, 6 patients received 3 courses of treatment, and 2 patients received 2 courses. Additionally, as of 14 March 2023, four patients died of non-malignant causes.
UNASSIGNED: QUAD SHOT schedule with VMAT RT may be an effective palliative treatment method with a good response rate, which positively affects patients\' quality of life in locally advanced non-melanoma skin cancer patients disqualified from surgery.