未经证实:Puumala汉坦病毒(PUUV)在欧洲引起大多数肾综合征出血热(HFRS)病例。PUUV感染的特征是急性肾损伤,血小板减少和毛细血管渗漏增加。典型的症状是发烧,头痛,恶心,腹部和背部疼痛。本研究旨在评估腹腔内的数量和分布,急性PUUV感染患者的腹膜后和胸腔积液以及积液与症状和临床表现的关联。
UNASSIGNED:对27例急性PUUV感染住院患者进行了腹部磁共振成像(MRI)。分析了临床和实验室检查结果以及患者症状与影像学检查结果的关系。从轴向图像以毫米(mm)测量流体集合的厚度。
未经证实:在所有患者中均发现了液体收集。腹腔积液量与血浆C反应蛋白(CRP)水平呈正相关(r=0.586,p=0.001),而与血清肌酐浓度呈负相关(r=-0.418,p=0.030)。腹膜后液也与血清肌酐和胱抑素C浓度呈负相关(分别为r=-0.501,p=.008和r=-0.383,p=.048)。腹部或背部疼痛患者的液体量不大。与没有背痛的患者相比,有背痛的患者有更高的血肌酐,452μmol/L(范围88-1071)与83μmol/L(范围60-679),p=.004。
未经证实:在所有患者中均发现了液体收集。较大量的腹腔积液与较高的CRP浓度相关,但与较高的血清肌酐水平无关。背痛与较高的肌酐水平有关,但与液体的存在无关。
Puumala hantavirus (PUUV) causes most cases of haemorrhagic fever with renal syndrome (HFRS) in Europe. PUUV infection is characterised by acute kidney injury, thrombocytopenia and increased capillary leakage. Typical symptoms are fever, headache, nausea, abdominal and back pain. This study aimed to evaluate the amount and distribution of intraperitoneal, retroperitoneal and pleural fluid and the association of fluid collections to the symptoms and clinical findings in patients with acute PUUV infection.
Abdominal magnetic resonance imaging (MRI) was performed on 27 hospitalised patients with acute PUUV infection. The clinical and laboratory findings and patients\' symptoms were analysed in relation to the imaging findings. The thickness of the fluid collections was measured in millimetres (mm) from axial images.
Fluid collections were found in all patients. The amount of intraperitoneal fluid correlated positively with plasma C-reactive protein (CRP) level (r = 0.586, p = .001), while it had an inverse correlation with serum creatinine concentration (r = -0.418, p = .030). Retroperitoneal fluid also correlated inversely with serum creatinine and cystatin C concentrations (r = -0.501, p = .008 and r = -0.383, p = .048, respectively). The amount of fluid was not greater in patients with abdominal or back pain. Patients with back pain had higher serum creatinine compared with patients without back pain, 452 µmol/L (range 88-1071) vs. 83 µmol/L (range 60-679), p = .004.
Fluid collections were found in all patients. A greater amount of intraperitoneal fluid associates with higher CRP concentrations but not with higher serum creatinine levels. Back pain associates with higher creatinine level but not with the presence of fluids.