目的:射频消融(RFA)是治疗肝脏肿瘤的有效方法。术前路径规划,在RFA治疗中起着至关重要的作用,需要医生有丰富的经验和能力。具体来说,正确和高度活跃的术前路径规划应确保整个穿刺过程的安全,肿瘤的完全消融和对健康组织的最小损伤。
方法:在本文中,提出了一种高安全性的肝肿瘤自动多次穿刺路径规划方法,其中消融次数的优化,穿刺号,研究了受临床综合约束的目标位置和穿刺点位置。特别是,同时考虑穿刺路径的安全性和消融椭圆体的分布。详细讨论了各个约束条件对整个穿刺过程安全性的影响。在此基础上,通过简化计算数据和优化变量,该规划方法的效率明显提高。此外,比较并总结了该方法对大型和小型肿瘤的性能和适应性。
结果:对来自7例的10个具有各种几何特征的肝肿瘤进行了评估。测试结果表明,平均路径规划时间和平均消融效率分别为41.4s和60.19%,分别。对于不同大小的肿瘤,从所提出的方法获得的规划结果具有相似的健康组织覆盖率。通过医生的临床评估,规划结果满足肝脏肿瘤RFA的需要。
结论:所提出的方法可以在RFA规划中提供合理的穿刺路径,有利于保证肝脏肿瘤消融的安全性和高效性。
OBJECTIVE: Radiofrequency ablation (RFA) is an effective method for the treatment of liver tumors. Preoperative path planning, which plays a crucial role in RFA treatment, requires doctors to have significant experience and ability. Specifically, correct and highly active preoperative path planning should ensure the safety of the whole puncturing process, complete ablation of tumors and minimal damage to healthy tissues.
METHODS: In this paper, a high-security automatic multiple puncture path planning method for liver tumors is proposed, in which the optimization of the ablation number, puncture number, target positions and puncture point positions subject to comprehensive clinical constraints are studied. In particular, both the safety of the puncture path and the distribution of ablation ellipsoids are taken into consideration. The influence of each constraint on the safety of the whole puncturing process is discussed in detail. On this basis, the efficiency of the planning method is obviously improved by simplifying the computational data and optimized variables. In addition, the performance and adaptability of the proposed method to large and small tumors are compared and summarized.
RESULTS: The proposed method is evaluated on 10 liver tumors of various geometric characteristics from 7 cases. The test results show that the average path planning time and average ablation efficiency are 41.4 s and 60.19%, respectively. For tumors of different sizes, the planning results obtained from the proposed method have similar healthy tissue coverage. Through the clinical evaluation of doctors, the planning results meet the needs of RFA for liver tumors.
CONCLUSIONS: The proposed method can provide reasonable puncture paths in RFA planning, which is beneficial to ensure the safety and efficiency of liver tumor ablation.