■成人肥胖是心血管事件的已知危险因素,并与动脉弹性下降有关。本研究旨在通过开发肥胖和超重个体动脉僵硬度的预测模型,评估脉搏波分析(PWA)参数在常规临床实践中对心血管事件一级预防的实用性。
■该研究招募了84名成年患者,18至85岁,不同程度的体重状态,包括最佳体重,超重,和肥胖。生活习惯,心脏代谢疾病的个人和家族史,以及包括BMI(体重指数)的临床评估,WHR(腰臀比),进行WC(腰部规避)。使用Mobil-O-Graph设备进行PWA评估,评估以下参数:脉搏波速度(PWV),增强指数(AIX),心率(HR),中心脉压(CPP),外周和中枢血压(SBP,DBP,CSBP,cDBP)。使用TANITABC-418身体分析仪进行身体成分分析。在每位患者的初始营养咨询期间,还收集了过去3个月的实验室结果。
■心血管事件家族史与所有PWA参数呈正相关,而糖尿病史仅有PWV和家族肥胖史,DBP,和CSBP。睡眠持续时间不足与除cDBP外的所有动脉僵硬度参数呈正相关。吸烟状态与PWV和Aix值显着升高相关,而体力活动不足仅与PWV相关。当前体重与PWV呈正相关,虽然WC与PWV呈正相关,SBP,和CSBP。身体成分分析显示躯干脂肪组织质量(%)和PWV之间存在显著关联,SBP,和CSBP。水化状态(%)是PWV的独立预测因子,表现出相反的关系。HOMA-IR(胰岛素抵抗的稳态模型评估)显示与PWV强的正相关。与HDL-c和维生素D呈负相关。年龄阈值,cDBP和心脏指数为血管损害提供阳性诊断。
■评估动脉僵硬度可被认为是预防肥胖相关心血管事件并促进此类病变的综合管理的可靠方法。
UNASSIGNED: Obesity in adults is a known risk factor for cardiovascular events and is associated with a decline in arterial elasticity. This study aims to evaluate the utility of pulse wave analysis (PWA) parameters in routine clinical practice for the primary prevention of cardiovascular events by developing a prediction model for arterial stiffness among obese and overweight individuals.
UNASSIGNED: The study enrolled 84 adult patients, aged 18 to 85 years, with varying degrees of weight status, including optimal weight, overweight, and obesity. The lifestyle habits, the personal and family history of cardiometabolic diseases, as well the clinical evaluation that included BMI (body mass index), WHR (waist-to-hip ratio), WC (waist circumferance) were performed. PWA evaluation was conducted using the Mobil-O-Graph device, assessing the following parameters: pulse wave velocity (PWV), augmentation index (AIx), heart rate (HR), central pulse pressure (cPP), peripheral and central blood pressure (SBP, DBP, cSBP, cDBP). Body composition analysis was performed using the TANITA BC-418 body analyzer. Laboratory results from the past 3 months were also collected during initial nutritional consultations for each patient.
UNASSIGNED: Family history of cardiovascular events showed positive correlations with all PWA parameters, while diabetes history only with PWV and family history of obesity with PWV, DBP, and cSBP. Insufficient sleep duration showed positive associations with all arterial stiffness parameters except cDBP. Smoking status correlated with significantly elevated PWV and Aix values, while insufficient physical activity was associated solely with PWV. Positive correlations were showed between current weight and PWV, while WC demonstrated positive associations with PWV, SBP, and cSBP. Body composition analysis revealed significant associations between trunk adipose tissue mass (%) and PWV, SBP, and cSBP. Hydration status (%) emerged as an independent predictor for PWV, exhibiting an inverse relationship. HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) showed a strong positive correlation with PWV. Negative associations were observed with HDL-c and vitamin D. Threshold values for age, cDBP and Cardiac Index providing positive diagnostic for vascular impairment.
UNASSIGNED: The assessment of arterial stiffness can be considered a reliable approach to prevent obesity-related cardiovascular events and facilitate the comprehensive management of such pathologies.