精神分裂症对个人和护理人员构成了重大挑战,经常导致反复住院。科学文献中提供了有关罗马尼亚精神分裂症和多次住院患者的有限信息。我们的研究旨在评估Cluj-Napoca单一中心多次住院的精神分裂症患者的特征,分析两次或两次以上住院患者之间或男女之间是否存在特定模式。我们根据国际疾病分类(ICD10)的第10次修订版对精神分裂症患者进行了回顾性研究,在克卢日-纳波卡县急诊医院住院,罗马尼亚,2018年至2022年。人口统计数据,躯体合并症,使用阳性和阴性综合征量表(PANSS)或简短精神病学评定量表(BPRS),抗精神病药物,并收集不良反应。我们评估了62例患者,年龄从23岁到57岁,157例住院(每位患者2至7例)。大多数患者没有精神分裂症(56.5%)或双相情感障碍(71%)的家族史。48个病人是男性,45人两次住院。年龄,性别,居住的地方和条件,出生季节,在两次或两次以上住院的患者中,婚姻状况相似(p值>0.10).在两次或两次以上住院的患者之间观察到有关吸烟的显着差异(63.3%vs.79.1%,p值=0.0029)和入院时的恐惧症状(40.0%vs.65.7%,p值=0.0015)。我们观察到出院时总体PANSS和BPRS评分低于入院时(p值<0.001),不管是哪个组(两次或两次以上住院,男人vs.women).男性和女性在住院时间上存在差异(中位数17.25vs.15天,p值<0.001)和入院时(p值=0.012)和出院时(p值=0.016)的BPRS评分。为两次入院的人开出的第一代抗精神病药物较少,近一半的人报告了不良反应,尤其是心动过速(29%),在群体中也有类似的发生。我们的结果显示,多次住院的候选人是男性,平均年龄37岁,未婚,和某人一起生活在城市环境中,更有可能是吸烟者表现出恐惧症状。
Schizophrenia poses significant challenges for individuals and caregivers, often leading to recurrent hospitalizations. Limited information on patients with schizophrenia and multiple hospitalizations in Romania is available in the scientific literature. Our study aimed to evaluate the characteristics of patients with schizophrenia with multiple hospitalizations in a single center in Cluj-Napoca, analyzing if specific patterns exist between patients with two or more hospitalizations or between men and women. We conducted a retrospective study on patients diagnosed with schizophrenia according to the 10th revision of the International Classification of Diseases (ICD 10), hospitalized at the County Emergency Hospital of Cluj-Napoca, Romania, between 2018 and 2022. Data on demographics, somatic comorbidities, symptom severity using the positive and negative syndrome scale (PANSS) or the brief psychiatric rating scale (BPRS), antipsychotic medication, and adverse effects were collected. We evaluated 62 patients, aged from 23 to 57 years, with 157 hospitalizations (ranging from two to seven per patient). No familial history of schizophrenia (56.5%) or bipolar disorder (71%) was reported by most patients. Forty-eight patients were male, and 45 had two hospitalizations. Age, sex, living place and conditions, season of birth, and marital status were similar in patients with two or more than two hospitalizations (p-values > 0.10). Significant differences were observed between patients with two or more than two hospitalizations regarding smoking (63.3% vs. 79.1%, p-value = 0.0029) and symptoms of fear at admission (40.0% vs. 65.7%, p-value = 0.0015). We observed lower scores in the overall PANSS and BPRS scores at discharge compared to admission (p-values < 0.001), regardless of the group (two or more than two hospitalizations, men vs. women). Men and women showed differences in hospitalization stays (median 17.25 vs. 15 days, p-value < 0.001) and BPRS scores at admission (p-value = 0.012) and discharge (p-value = 0.016). Fewer First-Generation Antipsychotics were prescribed for those with two admissions, and nearly half reported adverse effects, notably tachycardia (29%), with similar occurrence within groups. Our results showed that the candidate for multiple hospitalizations is a male, with a mean age of 37 years, unmarried, and living with someone in urban settings, more likely a smoker who exhibits fear symptoms.