Prostatic stent

  • 文章类型: Journal Article
    良性前列腺增生(BPH)是一种常见的慢性泌尿系统疾病,影响约50%的60岁以上的男性。根据欧洲泌尿外科协会指南,BPH可以根据从保守管理开始的逐步方法进行治疗,药理学的方法,最后是手术。药物治疗和手术治疗都有副作用,影响射精和性功能以及有多种合并症的患者可能不被认为是手术合适的候选人.前列腺支架在门诊提供微创手术,可能在局部麻醉下.自1980年代以来,过去的支架包括永久性(上皮形成)或暂时性(非上皮形成)装置,像Uro-Lume(美国医疗系统,Minnetonka,MN,美国)和Memokath,或Memotherm(工程师和医生A/S,Denmark),和由自增强的聚-L-丙交酯或编织的聚乳酸-共-乙醇酸制成的生物可降解支架。然而,以前的支架显示出相当高的并发症率,其中疼痛,失禁,感染,支架移动或阻塞,以及可能导致支架过早移除的不完全降解。目前市场上可获得的支架是临时设备Allium三角前列腺尿道支架(AlliumUrologicalSolutions,凯撒利亚,以色列)和临时支架SPANNER(AbbeyMoorMedical,Inc.,帕克草原,MN,美国),可用于膀胱流出道梗阻的情况,术后,或急性尿潴留。研究显示了令人鼓舞的结果,在有效性和安全性方面,提高患者的生活质量和国际前列腺症状评分,但需要进行更长期的研究,以确定可能从其使用中获益的最合适的患者.目前正在研究较新的支架和镍钛诺装置,我们正在等待正在进行的临床试验的结果。
    Benign prostatic hyperplasia (BPH) is a common chronic urologic condition affecting approximately 50% of men above the age of 60. As per European Association of Urology Guidelines, BPH can be treated according to a stepwise approach starting from a conservative management, a pharmacologic approach, and finally surgery. Both medical and surgical therapies have side effects, impacting on ejaculation and sexual function and patients with multiple comorbidities might not be considered surgically suitable candidates. Prostatic stents offer a minimally invasive procedures in an out-patient setting, possibly under local anaesthesia. Utilized since the 1980s, the past stents encompassed permanent (epithelializing) or temporary (non-epithelializing) devices, like the Uro-Lume (American Medical Systems, Minnetonka, MN, USA) and the Memokath, or Memotherm (Engineers & Doctors A/S, Denmark), and the biodegradable stents made of self-reinforced poly-L-lactide or braided poly lactic-co-glycolic acid. Previous stents however showed a quite high rate of complications among which pain, incontinence, infections, stent migration or blockage, and incomplete degradation that might lead to premature removal of stent. The stents currently available on the market instead are the temporary device Allium Triangular Prostatic Urethral Stent (Allium Urological Solutions, Caesarea, Israel) and the temporary stent SPANNER (AbbeyMoor Medical, Inc., Parkers Prairie, MN, USA), which might be used in case of bladder outflow obstruction, post-operatively, or for acute urinary retention. Studies showed encouraging results, in terms of effectiveness and safety improving patients\' quality of life and International Prostate Symptom Score, but longer-term studies are needed to identify the most suitable patients who might benefit from their use. Newer stents and nitinol devices are currently investigated, and we are waiting for the results of the ongoing clinical trials.
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  • 文章类型: Review
    目的:对前列腺支架治疗良性前列腺增生(BPH)的现有文献和最新进展进行范围综述。
    方法:在Embase上进行了全面搜索,MEDLINE,和WebofScience确定有关前列腺支架治疗BPH的英文文献。通过灰色文献检索和专家咨询确定了其他研究和即将到来的设备。对研究特征和支架信息进行了提取和列表叙述。
    结果:在1171个搜索结果中,该综述包括64项研究。iTiND是最长期证据的前列腺支架。iTiND是一种安全有效的BPH微创治疗方法,可保留性功能。不良事件是轻微和短暂的。新兴支架(例如Zenflow,蝴蝶,Urocross,和Exime)有7/64项合格研究,没有研究进行长期随访。这些较新的支架在生活质量和BPH症状管理方面显示出有希望的结果;然而,需要进行长期监测和头对头比较。
    结论:在过去的50年里,前列腺支架的发展和临床疗效的改善。iTiND为BPH继发的LUTS提供安全有效的门诊治疗,以保持勃起和射精功能。新兴的前列腺支架是有前途的,有效,以及对精心挑选的对其益处感兴趣的患者进行安全干预。
    OBJECTIVE: To conduct a scoping review of the existing literature and recent developments on prostatic stents for the treatment of benign prostatic hyperplasia (BPH).
    METHODS: A comprehensive search was performed on Embase, MEDLINE, and Web of Science to identify English literature on prostatic stents for the treatment of BPH. Additional studies and upcoming devices were identified through grey literature search and expert consultation. Study characteristics and stent information were extracted and tabulated narratively.
    RESULTS: Of the 1171 search results, 64 studies were included in this review. iTiND was the prostatic stent with the most long-term evidence. iTiND is a safe and effective minimally invasive treatment for BPH that preserves sexual function. Adverse events are mild and transitory. Emerging stents (e.g. Zenflow, Butterfly, Urocross, and Exime) had 7/64 eligible studies, where no studies had long-term follow-up. These newer stents show promising results for quality of life and BPH symptom management; however, long-term monitoring and head-to-head comparisons are needed.
    CONCLUSIONS: Over the last 50 years, prostatic stents have evolved and demonstrated improved clinical efficacy. iTiND provides a safe and effective outpatient treatment of LUTS secondary to BPH preserving erectile and ejaculatory function. Emerging prostatic stents are a promising, effective, and safe intervention in well-selected patients interested in its benefits.
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  • 文章类型: Journal Article
    Bladder outflow obstruction is a very common age-related clinical entity due to a variety of benign and malignant diseases of the prostate. Surgical treatment under general or regional anesthesia is not suitable for high-risk elderly patients who seek minimally invasive management. Unfortunately, for patients who are not fit for transurethral and/or laser prostatectomy, few treatment options remain, other than long-term catheterization and insertion (under local anesthesia) of a prostatic stent. In this review, we present developments in the use of prostatic stents.
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  • 文章类型: Case Reports
    一名90岁的男性前列腺增生,有缺血性心脏病和右侧偏瘫病史,由于急性尿潴留9个月,接受了Urolume支架置入术。支架已迁移到膀胱中,导致排尿困难和尿流不足。我们通过Holmium(HO:YAG)激光将前列腺支架碎裂,然后进行激光前列腺切除术。手术后,病人满意地排尿了。
    A 90-year-old male with prostatic hyperplasia with a history of ischemic heart disease and right-sided hemiplegia had undergone a Urolume stent placement because of acute urinary retention 9 months earliar. The stent had migrated into the bladder causing dysuria and a poor stream of urine. We fragmented the prostatic stent by Holmium (HO: YAG) laser followed by a laser prostatectomy. After the procedure, the patient voided satisfactorily.
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